Markers Of Androgen Action, Genetic Variation And Prostate Cancer Risk
Funder
National Health and Medical Research Council
Funding Amount
$798,907.00
Summary
This proposal aim to follow up evidence from a number of studies that genetic and non-genetic markers of hormonal action in different periods of a man's life are associated with prostate cancer risk using a collection of three large, independent epidemiologic studies on prostate cancer named the Prostate Cancer Program. A principal objective is to collect exposure data on acne and digit ratio, and genotype cases and controls across the studies of the Prostate Cancer Program for common genetic va ....This proposal aim to follow up evidence from a number of studies that genetic and non-genetic markers of hormonal action in different periods of a man's life are associated with prostate cancer risk using a collection of three large, independent epidemiologic studies on prostate cancer named the Prostate Cancer Program. A principal objective is to collect exposure data on acne and digit ratio, and genotype cases and controls across the studies of the Prostate Cancer Program for common genetic variants in 4 candidate genes in the hormonal pathway. The established risk factors for prostate cancer are only age, race and family history. We anticipate that this project will cast light on the role of hormones in prostate cancer and that we will identify new markers of risk of prostate cancer and markers of disease aggressiveness. These outcomes will help us identifying men who are at risk for prostate cancer to target screening and surveillance, and plan prevention strategies. Furthermore, they will also form the basis for research on treatment targets.Read moreRead less
Statistical Analysis Of An International 10 Year Prospective Family Study Of Gene-environment Interactions On Risk Of Female Breast Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$450,198.00
Summary
This study will provide new and credible information on how the effects of environmental and lifestyle factors on breast cancer risk depend on a woman's underlying genetic susceptibility using a large, international 10 year prospective family study.
An investigation of illicit tobacco use - its prevalence, economic impact and the motivations and perceptions of consumers. Black market tobacco costs the Australian government at least $450 million in lost taxes per annum. Little is known about the prevalence and economics of illicit tobacco use, or the motivations, attitudes and perceptions of consumers. Using a national telephone survey of licit and illicit tobacco consumers, we will investigate their economic thresholds, decision-making pr ....An investigation of illicit tobacco use - its prevalence, economic impact and the motivations and perceptions of consumers. Black market tobacco costs the Australian government at least $450 million in lost taxes per annum. Little is known about the prevalence and economics of illicit tobacco use, or the motivations, attitudes and perceptions of consumers. Using a national telephone survey of licit and illicit tobacco consumers, we will investigate their economic thresholds, decision-making processes, and perceptions of health effects. Our work will lead to improved supply and demand reduction measures for illicit tobacco, and enable development of appropriately targeted health promotion strategies, generating enduring benefit to Australia's economy and public health. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100825
Funder
Australian Research Council
Funding Amount
$336,128.00
Summary
Evaluating interventions to prevent serious road traffic crashes. This project aims to advance knowledge on the prevention of road traffic crashes that result in serious injury or death. Road traffic injuries are the second leading cause of hospitalised injury and injury-related deaths in Australia, and are estimated to cost the economy $27 billion annually. This project will establish a data collection system that will evaluate existing and novel countermeasures to serious road traffic crashes. ....Evaluating interventions to prevent serious road traffic crashes. This project aims to advance knowledge on the prevention of road traffic crashes that result in serious injury or death. Road traffic injuries are the second leading cause of hospitalised injury and injury-related deaths in Australia, and are estimated to cost the economy $27 billion annually. This project will establish a data collection system that will evaluate existing and novel countermeasures to serious road traffic crashes. The outcome of this project will inform road safety policies and cost-effective countermeasures. Insights from the project can contribute to road safety improvements in Australia and a substantial reduction in the burden of fatal and non-fatal road traffic injury.Read moreRead less
Special Research Initiatives - Grant ID: SR0566924
Funder
Australian Research Council
Funding Amount
$52,825.00
Summary
Develop and pilot an e-cohort research technique for longitudinal studies using multiple international cohorts. The aim of this project is to develop and pilot an e-cohort research methodology suitable for longitudinal studies with multiple international cohorts. Historically, studies of this nature are expensive as they are conducted in traditional paper-based mode and the studies are therefore confined to one country. Population-based epidemiological studies of this type have led to major scie ....Develop and pilot an e-cohort research technique for longitudinal studies using multiple international cohorts. The aim of this project is to develop and pilot an e-cohort research methodology suitable for longitudinal studies with multiple international cohorts. Historically, studies of this nature are expensive as they are conducted in traditional paper-based mode and the studies are therefore confined to one country. Population-based epidemiological studies of this type have led to major scientific advances in global health for the last sixty years. Developing and employing e-research techniques in longitudinal studies will significantly reduce the costs of this important research and enable multi-national cohorts of participants that will result in high quality research.Read moreRead less
Optimising the Utility of Injury Surveillance Systems for Injury Prevention in Active Populations. Promotion of physical activity is a key national health priority and a major focus for the Australian Defence Force to achieve and maintain operational fitness. Unfortunately, these goals are associated with the negative effects of increased injury occurrence and substantial related costs. Civilian and military injury surveillance systems inform injury prevention priorities and interventions but re ....Optimising the Utility of Injury Surveillance Systems for Injury Prevention in Active Populations. Promotion of physical activity is a key national health priority and a major focus for the Australian Defence Force to achieve and maintain operational fitness. Unfortunately, these goals are associated with the negative effects of increased injury occurrence and substantial related costs. Civilian and military injury surveillance systems inform injury prevention priorities and interventions but research is required to maximise their performance and utility. The project aims to 1) determine the extent to which current systems meet user requirements 2) assess utility and reliability of these systems specifically for active populations and 3) develop recommendations for future systems development and improved user application.Read moreRead less
The structure and dynamics of social contact for human disease transmission models. The methodological advances of this project will enable new insights in important social research. They will not only add significantly to national capacity in the modelling of complex social systems but they will also yield practical scientific outcomes in a significant policy domain in Australia and overseas. In Australia, response to diseases such as HIV, HCV and TB need new approaches, and the threat of pan ....The structure and dynamics of social contact for human disease transmission models. The methodological advances of this project will enable new insights in important social research. They will not only add significantly to national capacity in the modelling of complex social systems but they will also yield practical scientific outcomes in a significant policy domain in Australia and overseas. In Australia, response to diseases such as HIV, HCV and TB need new approaches, and the threat of pandemic influenza is significant. Read moreRead less
Factors associated with the recruitment and retention of the current and future nursing workforce - a longitudinal e-cohort study. The overall effectiveness of the Australian health care system is dependent on a knowledgeable, skilled and viable nursing workforce. Currently there is a critical shortage of qualified nurses actively working in the Australian health care system which limits the capacity of the system to effectively manage an ageing population. The broad aim of this research project ....Factors associated with the recruitment and retention of the current and future nursing workforce - a longitudinal e-cohort study. The overall effectiveness of the Australian health care system is dependent on a knowledgeable, skilled and viable nursing workforce. Currently there is a critical shortage of qualified nurses actively working in the Australian health care system which limits the capacity of the system to effectively manage an ageing population. The broad aim of this research project is to examine factors associated with recruitment and retention of the current and future nursing workforce across metropolitan, regional and rural areas; with a particular focus on work-based injury. In addition, the project will employ smart use of information technology to develop innovative e-cohort techniques.Read moreRead less
Stochastic methods for studying models of infection and abundance. The outcomes of this project will have immense benefit to Australia. They impact upon two areas of national importance, namely ensuring an environmentally sustainable Australia, and safeguarding Australia. In particular, the project will provide models, methodology and optimal strategies for sustainable use of Australia's biodiversity, for protecting Australia from invasive diseases and pests, and for protecting Australia from te ....Stochastic methods for studying models of infection and abundance. The outcomes of this project will have immense benefit to Australia. They impact upon two areas of national importance, namely ensuring an environmentally sustainable Australia, and safeguarding Australia. In particular, the project will provide models, methodology and optimal strategies for sustainable use of Australia's biodiversity, for protecting Australia from invasive diseases and pests, and for protecting Australia from terrorism and crime. Special focus will be given to the control of invasive species, the control of emerging infections, and the optimal allocation of resources. The current risks posed by invasive diseases and pests, and the alarming rate of destruction of biodiversity, warrant urgent funding of this project.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100456
Funder
Australian Research Council
Funding Amount
$375,288.00
Summary
The interaction between injury compensation and social security systems. With the ultimate goal of reducing the road traffic crash burden in Australia, on individuals, their families, and on the nation's social support systems, the project will determine the impact of pre-claim social factors on compensation system outcomes including claim duration, benefits and costs, and the impact of compensation system design on claim and social outcomes of road traffic crash survivors. Addressing an unmet n ....The interaction between injury compensation and social security systems. With the ultimate goal of reducing the road traffic crash burden in Australia, on individuals, their families, and on the nation's social support systems, the project will determine the impact of pre-claim social factors on compensation system outcomes including claim duration, benefits and costs, and the impact of compensation system design on claim and social outcomes of road traffic crash survivors. Addressing an unmet need, this project will determine the impact of macro-level compensation system design on social and claim outcomes and allows identification of groups at higher risk for poor post-crash outcomes, in whom earlier identification and intervention can improve these, and potentially save the Australian economy $300m annually.Read moreRead less