Regulation of saxitoxin production in bacteria and algae. In Australia, toxic algal blooms have had a devastating impact on marine and freshwater resources. In collaboration with a biotechnology company, this project will develop exciting new methods based on information regarding the genetics of the toxin, to monitor and potentially mitigate the effects of algal blooms on water supplies and aquaculture industries. We will use this method to determine the impact of light and salinity in regulati ....Regulation of saxitoxin production in bacteria and algae. In Australia, toxic algal blooms have had a devastating impact on marine and freshwater resources. In collaboration with a biotechnology company, this project will develop exciting new methods based on information regarding the genetics of the toxin, to monitor and potentially mitigate the effects of algal blooms on water supplies and aquaculture industries. We will use this method to determine the impact of light and salinity in regulating toxin production in cyanobacteria and algae.Read moreRead less
New tools to decipher, predict and manage pacific oyster mortality episodes. This project aims to unite cutting-edge genomic and molecular biological tools with novel quantitative modelling analyses to identify the mechanisms behind oyster disease events. Oyster farming contributes almost $100 million to the Australian economy each year and is a cornerstone of coastal communities, but has been decimated by diseases that threaten this important primary industry. While some causative pathogens hav ....New tools to decipher, predict and manage pacific oyster mortality episodes. This project aims to unite cutting-edge genomic and molecular biological tools with novel quantitative modelling analyses to identify the mechanisms behind oyster disease events. Oyster farming contributes almost $100 million to the Australian economy each year and is a cornerstone of coastal communities, but has been decimated by diseases that threaten this important primary industry. While some causative pathogens have been identified, the environmental catalysts of oyster disease remain a mystery. The expected outcome of this project is an innovative coupling of tools that provides new capacity to forecast disease events, delivering the Australian oyster industry a powerful platform to predict, manage and prevent costly disease outbreaks. By identifying environmental thresholds and oyster disease danger periods, an expected outcome of this project is the development of new oyster farming strategies aimed at avoiding multi-million dollar losses associated with disease outbreaks.Read moreRead less
In-Vitro Production of Baculovirus Biopesticides - A Systems Biology Approach. This project has the potential to develop an in-vitro production process that can produce large quantities of Baculoviruses at costs comparable to selective chemicals. This could transform agriculture allowing farmers to choose an insect control option that is both safe and efficacious to use as well as economically and environmentally superior to chemicals, and less controversial than transgenic plants. This outcome ....In-Vitro Production of Baculovirus Biopesticides - A Systems Biology Approach. This project has the potential to develop an in-vitro production process that can produce large quantities of Baculoviruses at costs comparable to selective chemicals. This could transform agriculture allowing farmers to choose an insect control option that is both safe and efficacious to use as well as economically and environmentally superior to chemicals, and less controversial than transgenic plants. This outcome would enhance Australia's reputation in the animal cell technology field (related technology is used to produce protein pharmaceutical products), and will earn significant export dollars through licensing out of the technology or through large scale manufacturing and export of the product itself. Read moreRead less
Developing a chlamydial vaccine for koalas. Developing a chlamydial vaccine for koalas . This project aims to produce an optimised, safe, field-tested, protective Chlamydia vaccine for koalas. In many regions of Australia, Chlamydia infection severely reduces female koala reproductive rates, threatening the species’ long term survival. This project builds on work developing a prototype vaccine for koala Chlamydia, and intends to produce a vaccine ready for potential registration and use by koala ....Developing a chlamydial vaccine for koalas. Developing a chlamydial vaccine for koalas . This project aims to produce an optimised, safe, field-tested, protective Chlamydia vaccine for koalas. In many regions of Australia, Chlamydia infection severely reduces female koala reproductive rates, threatening the species’ long term survival. This project builds on work developing a prototype vaccine for koala Chlamydia, and intends to produce a vaccine ready for potential registration and use by koala care centres, wildlife hospitals and government departments.Read moreRead less
Development of a vaccine to protect koalas against koala retrovirus (KoRV). This project aims to develop a vaccine against koala retrovirus (KoRV) to arrest the increasing loss of animals due to this infection. Along with Chlamydia, KoRV threatens the long-term survival of the koala. KoRV infects over 95 per cent of Australia’s koalas and has been strongly linked to lymphoma and leukemia. Although quarantine and antiretroviral drug treatment are possible control measures, they are impractical in ....Development of a vaccine to protect koalas against koala retrovirus (KoRV). This project aims to develop a vaccine against koala retrovirus (KoRV) to arrest the increasing loss of animals due to this infection. Along with Chlamydia, KoRV threatens the long-term survival of the koala. KoRV infects over 95 per cent of Australia’s koalas and has been strongly linked to lymphoma and leukemia. Although quarantine and antiretroviral drug treatment are possible control measures, they are impractical in the wild, leaving vaccination as the only realistic option. This is valuable for both wild and captive koalas; zoos report high animal losses due to KoRV-associated lymphoma. The main outcome will be a KoRV vaccine which can be combined with a Chlamydia vaccine which is being developed in parallel.Read moreRead less