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Cardiovascular disease is the biggest killer in Australia. It describes diseases of the heart and blood vessels including heart attack and stroke. The risk of developing these diseases is affected by our diet and lifestyle and also by our genetic makeup that we inherit. In this project we are aiming to identify the specific heritable genetic differences between individuals that put us at greater risk of cardiovascular disease. We are studying large families from the Busselton Health Study.
Monitoring cardiovascular risk is a major part of the clinical workload both in general practice and specialty areas, but it is an under-researched area, reflected in a general lack of evidence based guidelines. My research will evaluate how to optimise the monitoring of cardiovascular risk both before and after starting treatment. By maximising clinical benefits for patients and minimising unnecessary resource use, my research will benefit patients, clinicians and the community at large.
Obesity, Pre-diabetes And Future Risk Of Diabetes: Maximising The Evidence, Minimising The Cost
Funder
National Health and Medical Research Council
Funding Amount
$470,136.00
Summary
The overarching aim of this proposal is to reliably determine how best to identify people at high risk of developing future diabetes. We will do this by using information on biological and behavioural risk factors that was collected on nearly 200,000 people many years ago and who were subsequently followed up to see who developed diabetes. This information will be used to create a risk prediction tool for spotting individuals most at risk of developing diabetes at some point in the future.
Developmental Origins Of Adult Cardiovascular Disease: Vascular Health In The Raine Cohort
Funder
National Health and Medical Research Council
Funding Amount
$1,087,427.00
Summary
The Raine study is a unique long term experiment that has collected extensive pre-birth and childhood data in ~3000 young Australians, who are now 27 years old. We plan to measure the artery health of 1200 of these volunteers and to determine what factors, both before and after birth, influence the presence of early atherosclerosis in humans. This study will guide strategies aimed at early prevention of heart attacks and stroke in humans, by defining the major risk factors.
The assessment of thrombosis requires the holistic evaluation of in-vivo coagulation including total clot formation. Unfortunately, current tests only evaluate the time to the start of clot formation. Experimental biomarkers such us thrombin generation, endothelial markers, microparticles and microRNA may provide a better framework for evaluating thrombotic risk. Translation of these markers to clinical use requires understanding of their expression in the normal population and assessment of the ....The assessment of thrombosis requires the holistic evaluation of in-vivo coagulation including total clot formation. Unfortunately, current tests only evaluate the time to the start of clot formation. Experimental biomarkers such us thrombin generation, endothelial markers, microparticles and microRNA may provide a better framework for evaluating thrombotic risk. Translation of these markers to clinical use requires understanding of their expression in the normal population and assessment of their ability to detect thrombotic disorders.Read moreRead less
The proportion of the population over 65 years of age is increasing, and cardiovascular disease (CVD) is a leading cause of disability and death in this group of people. Angina, heart failure and stroke in elderly people often result in considerable disability and in many instances in a need for changed living circumstances such as admission to nursing homes. Consequently there is an important need to understand how to prevent and manage cardiovascular diseases in elderly people. Although CVD oc ....The proportion of the population over 65 years of age is increasing, and cardiovascular disease (CVD) is a leading cause of disability and death in this group of people. Angina, heart failure and stroke in elderly people often result in considerable disability and in many instances in a need for changed living circumstances such as admission to nursing homes. Consequently there is an important need to understand how to prevent and manage cardiovascular diseases in elderly people. Although CVD occurs much more frequently in older persons, much of the epidemiological information on CVD risk factors and risk estimation comes from studies of middle-aged populations. Recently there has been an increased focus on whether the established relationships hold or differ in the elderly. This has generated debate about the relative value and effectiveness of treating risk factors in elderly people. This study, which is based on comprehensive and long-term risk factor, mortality and morbidity data from the Busselton Health Study and Health in Men Study, will lead to a better understanding of classic and new CVD risk factors in older persons and will contribute positively to the debate about the relative value and effectiveness of attempting to modify risk factors in the elderly. Further, it will facilitate improved methods for CVD risk assessment in older people and hence assist in determining whether which preventive actions to implement in the elderly.Read moreRead less
Investigating The Genetic Correlation Underlying The Developmental Origins Of Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
The prevalence of cardiovascular disease and diabetes is increasing and the financial burden on society is substantial. Research has shown a link between birth weight and increased risk of these diseases. Genetics may be involved as not all individuals born of suboptimal weight go on to develop disease. This research will identify genes that jointly affect birth weight and future risk of adult disease, leading to a better understanding of the biological relationship between the two.
Understanding Ethnic Differences In The Relationships Between Cardiovascular Risk Factors And Cardiovascular Disease In High Risk Populations
Funder
National Health and Medical Research Council
Funding Amount
$151,374.00
Summary
Cardiovascular disease (disease of the heart and blood vessels) is the leading cause of death world-wide. However, the burden of this disease is significantly greater in some populations, including Indigenous Australians and South Asians (Indians, Pakistanis or Bangladeshis). This project therefore aims to improve our understanding of CVD risk in these populations, and to develop better clinical assessment tools that will assist in the early detection and management of CVD in these individuals.