Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric ....Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric oxide regulates large artery stiffness and we believe that other endothelial mediators are also important regulators. Therefore, we aim to explore this in a series of studies. Regulation of stiffness of large arteries will improve treatment of age-related cardiovascular disease (eg isolated systolic hypertension)Read moreRead less
New Materials for an Implantable Blood Pump. Rotary blood pumps are at the leading edge of heart assist technology. VentrAssist has developed an innovative rotary blood pump with a hydro-dynamically suspended impeller. Advanced surface modifications will enable the device to be fabricated from polymers; this will make the device light, more compatible with the human body and less costly to produce. Surface treatments and coatings will be applied using ion implantation, to impart the required ....New Materials for an Implantable Blood Pump. Rotary blood pumps are at the leading edge of heart assist technology. VentrAssist has developed an innovative rotary blood pump with a hydro-dynamically suspended impeller. Advanced surface modifications will enable the device to be fabricated from polymers; this will make the device light, more compatible with the human body and less costly to produce. Surface treatments and coatings will be applied using ion implantation, to impart the required dimensional stability, impermeability and wear resistance. Following sophisticated experiments of modified materials, the best candidates will be used in prototype devices, for final selection of the optimal materials for the new device.Read moreRead less
Electric field effects on cochlear tissues. The project aims to solve the underlying biology of how electricity flows through the cochlear tissues, where and how electrical stimulation excites the auditory neurons, and what the effects of sustained electrical stimulation are on the nerve fibre growth and function. The research aims to show how electric fields can be controlled in the cochlea, and how auditory nerve fibres are affected at the cellular and molecular level. The long-term aim is to ....Electric field effects on cochlear tissues. The project aims to solve the underlying biology of how electricity flows through the cochlear tissues, where and how electrical stimulation excites the auditory neurons, and what the effects of sustained electrical stimulation are on the nerve fibre growth and function. The research aims to show how electric fields can be controlled in the cochlea, and how auditory nerve fibres are affected at the cellular and molecular level. The long-term aim is to utilise these findings to improve the control of neuronal excitability, for development of interfaces with the nervous system.Read moreRead less
Understanding plant uptake of organic and inorganic nitrogen for optimal fertiliser application in forestry. Nitrogen (N) in soils occurs in both organic and inorganic forms. Plants can take up inorganic N - nitrate and ammonium - but, on average, these account for only 5% of the soluble N in soils. Recent evidence suggests that plants may be able to tap into some of the 95% of N that occurs in organic forms. We will investigate the importance of organic N uptake for two plantation Eucalyptus sp ....Understanding plant uptake of organic and inorganic nitrogen for optimal fertiliser application in forestry. Nitrogen (N) in soils occurs in both organic and inorganic forms. Plants can take up inorganic N - nitrate and ammonium - but, on average, these account for only 5% of the soluble N in soils. Recent evidence suggests that plants may be able to tap into some of the 95% of N that occurs in organic forms. We will investigate the importance of organic N uptake for two plantation Eucalyptus species by tracing the uptake of different N forms by bacteria, fungi and eucalypts. This information will redefine what is meant by 'available N' and will guide the development of a new test for soil N status.Read moreRead less
Transport systems that underpin nitrogen efficient maize. This project aims to define the nitrogen transport network involved in the uptake, storage and redistribution of inorganic nitrogen (nitrate and ammonium) over the developmental life cycle of maize. This information will provide novel insight into the genetic control of nitrogen use in maize and other cereal crops.
Nutritional and bacterial influences on gut and peripheral homeostasis. Nutritional and bacterial influences on gut and peripheral homeostasis. This project aims to understand the role of macronutrients on gut homeostasis. While the understanding of what factors affect gut homeostasis is still in its infancy, scientists know that its disruption contributes to a broad range of inflammatory diseases, including type 1 diabetes and asthma. This project will determine the role of specific macronutrie ....Nutritional and bacterial influences on gut and peripheral homeostasis. Nutritional and bacterial influences on gut and peripheral homeostasis. This project aims to understand the role of macronutrients on gut homeostasis. While the understanding of what factors affect gut homeostasis is still in its infancy, scientists know that its disruption contributes to a broad range of inflammatory diseases, including type 1 diabetes and asthma. This project will determine the role of specific macronutrients on gut microbiota, gut epithelium, and immunity in mice, and the receptors involved. This research could ultimately lead to significant decreases in the cost of healthcare.Read moreRead less
Use of Gradipore technology to develop novel methods for the preparation and segregation of mammalian spermatozoa. The purpose of this project is to harness the expertise available within an Australian biotechnology company, Gradipore, to develop novel methods for the preparation of mammalian spermatozoa and the segregation of these cells into X-and Y- bearing populations. This technology will find application in: (1)clinical andrology, where rapid, safe protocols for the preparation and segrega ....Use of Gradipore technology to develop novel methods for the preparation and segregation of mammalian spermatozoa. The purpose of this project is to harness the expertise available within an Australian biotechnology company, Gradipore, to develop novel methods for the preparation of mammalian spermatozoa and the segregation of these cells into X-and Y- bearing populations. This technology will find application in: (1)clinical andrology, where rapid, safe protocols for the preparation and segregation of human spermatozoa are being actively sought in the context of assisted conception and the management of sex-linked genetic diseases and (2) agriculture, particularly the cattle industry, where a capacity to predetermine the sex of the offspring would be extremely valuable.Read moreRead less
Evaluating the effects of fipronil, a moderately persistent new generation pesticide, on Australian native vertebrates. The Australian Plague Locust Commission is considering replacing an organophosphate pesticide with fipronil, a relatively new phenyl pyrazole pesticide, because it more specifically targets invertebrate animals. However, fipronil is more environmentally persistent, has high lipid solubility, is known to disrupt thyroid function and has wide variation in its toxicity to vertebra ....Evaluating the effects of fipronil, a moderately persistent new generation pesticide, on Australian native vertebrates. The Australian Plague Locust Commission is considering replacing an organophosphate pesticide with fipronil, a relatively new phenyl pyrazole pesticide, because it more specifically targets invertebrate animals. However, fipronil is more environmentally persistent, has high lipid solubility, is known to disrupt thyroid function and has wide variation in its toxicity to vertebrates . These characteristics place native vertebrate species at risk. Further, because peak locust activity is coincident with vertebrate breeding, there is likelihood that fipronil will affect development of young and the health of adults. We propose to launch the first comprehensive study of fipronil's effects on the health and vitality of native vertebrate adults and their offspring. We will focus on dasyurid marsupials and native birds that co-occur with plague locusts.Read moreRead less
A randomised controlled trial of motivational interviewing as a tool to enhance secondary prevention strategies in cardiovascular disease. While there is increasing evidence for the efficacy of cardiac rehabilitation (CR) in reducing mortality and morbidity, adherence to risk factor modification strategies are problematic for many CR patients. This project will evaluate in a randomised controlled trial the benefit of motivational interviewing (MI) in enhancing secondary prevention strategies in ....A randomised controlled trial of motivational interviewing as a tool to enhance secondary prevention strategies in cardiovascular disease. While there is increasing evidence for the efficacy of cardiac rehabilitation (CR) in reducing mortality and morbidity, adherence to risk factor modification strategies are problematic for many CR patients. This project will evaluate in a randomised controlled trial the benefit of motivational interviewing (MI) in enhancing secondary prevention strategies in CR patients. Given the role of self-efficacy in predicting adherence, MI needs to be evaluated in CR. This study is significant in terms of preventative health, and its potential to improve the design and delivery of CR programs and increase patient adherence. Expected outcomes include increased adherence to cardiovascular risk modification and improved psychological well-being.Read moreRead less
QX DISEASE RESISTANCE IN SYDNEY ROCK OYSTERS. QX is a fatal disease of Sydney rock oysters. The protozoan parasite that causes QX has been identified in more than one third of oyster farming areas on the east coast of Australia. Disease outbreaks have already destroyed the oyster industry in some of those areas. This project tests whether a novel form of defensive protein that has been identified in some oysters can be used as a genetic marker of QX disease resistance. The selective breeding of ....QX DISEASE RESISTANCE IN SYDNEY ROCK OYSTERS. QX is a fatal disease of Sydney rock oysters. The protozoan parasite that causes QX has been identified in more than one third of oyster farming areas on the east coast of Australia. Disease outbreaks have already destroyed the oyster industry in some of those areas. This project tests whether a novel form of defensive protein that has been identified in some oysters can be used as a genetic marker of QX disease resistance. The selective breeding of disease resistant oysters based on such a genetic marker would help to control QX and secure the future of Australia's rock oyster industry.Read moreRead less