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Identification of structural proteins in the tissue cyst wall of Toxoplasma gondii. Most infections with Toxoplasma gondii are asymptomatic, however, infection during pregnancy can lead to miscarriage or blindness, deafness and mental retardation in the developing baby. Furthermore, in AIDS patients, toxoplasmosis is the leading cause of fatal encephalitis as the normally dormant tissue cysts are reactivated in the absence of an effective immune system. In Australia, it has been estimated that ~ ....Identification of structural proteins in the tissue cyst wall of Toxoplasma gondii. Most infections with Toxoplasma gondii are asymptomatic, however, infection during pregnancy can lead to miscarriage or blindness, deafness and mental retardation in the developing baby. Furthermore, in AIDS patients, toxoplasmosis is the leading cause of fatal encephalitis as the normally dormant tissue cysts are reactivated in the absence of an effective immune system. In Australia, it has been estimated that ~30% of the population is infected with T. gondii and the occurrence of congenital toxoplasmosis is 0.2% of live births, which translates to roughly 500 cases/year. Our research will identify structural proteins in Toxoplasma cyst walls that will lead to the design of new strategies to control the diseases caused by these parasites.Read moreRead less
Degradation of Trace Contaminants Using Sonochemistry and Peroxide Scavenging Advanced Oxidation Processes. Sonochemical degradation of hazardous organic compounds in aqueous solution has been examined extensively in recent years and found to be an effective means of waste treatment however the scavenging of hydroxyl radicals by the relatively high concentrations of hydrogen peroxide produced limits the amount of reactive radicals accessible to target molecules. In this project we will investiga ....Degradation of Trace Contaminants Using Sonochemistry and Peroxide Scavenging Advanced Oxidation Processes. Sonochemical degradation of hazardous organic compounds in aqueous solution has been examined extensively in recent years and found to be an effective means of waste treatment however the scavenging of hydroxyl radicals by the relatively high concentrations of hydrogen peroxide produced limits the amount of reactive radicals accessible to target molecules. In this project we will investigate, by both experimental and computational means, options for the regeneration of hydroxyl radicals through use of hydrogen peroxide. Methods of particular interest include use of Fenton's reagent and ozone.Read moreRead less
Fluid mechanics and physiology of blockages in vascular systems. Vascular disease is a major health problem both in Australia and worldwide. In particular, cardiovascular disease is a major killer of adult Australians. Engineers and mathematicians working with biologists will gain a greater understanding of vascular diseases, a major health problem, including cardiovascular disease, which is one of the biggest killers worldwide, as well as tackling renal circulation problems, which are a signifi ....Fluid mechanics and physiology of blockages in vascular systems. Vascular disease is a major health problem both in Australia and worldwide. In particular, cardiovascular disease is a major killer of adult Australians. Engineers and mathematicians working with biologists will gain a greater understanding of vascular diseases, a major health problem, including cardiovascular disease, which is one of the biggest killers worldwide, as well as tackling renal circulation problems, which are a significant problem and may contribute to hypertension. Detailed measurement and prediction will be undertaken of the mechanical loading and response of cells to their microenvironment, an important first step to controlling pathological responses which lead to a variety of autoimmune problems.Read moreRead less
Drying sewage sludge using hot oil. The project seeks to investigate and develop an entirely new area of fundamental and applied research involving the process, mechanisms and kinetics of direct dehydration of sewage sludge by fry-drying in hot oil. Frying can be carried out as a drying process, though it not widely recognized or applied in this way, and has consequently not been exploited outside of the traditional food industries. It potentially provides a wide range of significant benefits ....Drying sewage sludge using hot oil. The project seeks to investigate and develop an entirely new area of fundamental and applied research involving the process, mechanisms and kinetics of direct dehydration of sewage sludge by fry-drying in hot oil. Frying can be carried out as a drying process, though it not widely recognized or applied in this way, and has consequently not been exploited outside of the traditional food industries. It potentially provides a wide range of significant benefits for sludge drying, including high efficiency and low costs, and produces a non-offensive product with a high energy value suitable for (renewable) power generation.Read moreRead less
Synthesis and Characterization of Novel Hybrid star polymers grown from carbohydrate clusters. The aim of the project is to make complex polymer architectures based on stars grown from sugar clusters. The star molecules are expected to have unique properties for transporting guest molecules in drug delivery systems. The outcome will be the development of totally biodegradable, non-toxic cluster/star structures capable of complexing to drugs. This is the first attempt to utilise these clusters ....Synthesis and Characterization of Novel Hybrid star polymers grown from carbohydrate clusters. The aim of the project is to make complex polymer architectures based on stars grown from sugar clusters. The star molecules are expected to have unique properties for transporting guest molecules in drug delivery systems. The outcome will be the development of totally biodegradable, non-toxic cluster/star structures capable of complexing to drugs. This is the first attempt to utilise these clusters, with sugar-based vinyl monomers for star synthesis.Read moreRead less
Heparan sulfate proteoglycan from smooth muscle cell basal lamina: It's role in cell signalling. Heart disease is the major killer of people in the Western world. central to this disease is the killing of heart muscle tissue to it being starved of oxygen via a "heart attack". One of the common treatments is coronary artery bypass surgery, however, the supply of vessels that can be used is limited. In order to provide an alternative supply of vessels, we are aiming to engineer blood vessels i ....Heparan sulfate proteoglycan from smooth muscle cell basal lamina: It's role in cell signalling. Heart disease is the major killer of people in the Western world. central to this disease is the killing of heart muscle tissue to it being starved of oxygen via a "heart attack". One of the common treatments is coronary artery bypass surgery, however, the supply of vessels that can be used is limited. In order to provide an alternative supply of vessels, we are aiming to engineer blood vessels in the laboratory. The major cell of the wall of arteries, the smooth muscle cell, is critical to normal functioning and integration of these transplanted arteries. To do this we will need to understand the cell signalling responses of these cells in relation to molecules in their surrounding environment.Read moreRead less
Inhibitors of meso-diaminopimelic acid (meso-DAP) and lysine biosynthesis: targeting dihydrodipicolinate synthase. With antibiotic resistance on the rise, there is an urgent need to develop new antibiotics with novel modes of action. This project aims to generate new drug candidates that target dihydrodipicolinate synthase (DHDPS) - the first enzyme in the synthesis of the bacterial cell wall - using a triple-pronged approach. This novel approach will allow for the development of new drugs to tr ....Inhibitors of meso-diaminopimelic acid (meso-DAP) and lysine biosynthesis: targeting dihydrodipicolinate synthase. With antibiotic resistance on the rise, there is an urgent need to develop new antibiotics with novel modes of action. This project aims to generate new drug candidates that target dihydrodipicolinate synthase (DHDPS) - the first enzyme in the synthesis of the bacterial cell wall - using a triple-pronged approach. This novel approach will allow for the development of new drugs to treat a range of pathogenic bacteria, including "Golden Staph".Read moreRead less
Establishing the relationship between water characteristics and fouling of membranes used in water reuse. The project will result in the following significant benefits to the Australian and international partners: a state-of-the-art laboratory and semi-pilot system from which a full-scale system could be developed and tested, funded by the water industry; an outstanding research project for postgraduate students at the University of Technology, Sydney (UTS), Gwangji Institute of Science and Tech ....Establishing the relationship between water characteristics and fouling of membranes used in water reuse. The project will result in the following significant benefits to the Australian and international partners: a state-of-the-art laboratory and semi-pilot system from which a full-scale system could be developed and tested, funded by the water industry; an outstanding research project for postgraduate students at the University of Technology, Sydney (UTS), Gwangji Institute of Science and Technology, Korea (GIST) and Yale University; and fostering a culture of innovation in the wastewater industry in Australia, Korea and USA and contributing to the commercialization of research by UTS, GIST and YU.Read moreRead less
The Development of Novel Task Specific and Biodegradable Ionic Liquids. The advance of ?Green Chemistry? has become a forefront issue in mainstream chemistry. Green Chemistry is aimed at the reduction or elimination of hazardous substances in the design, manufacture and application of chemical products. The advent of ionic liquids (ILs) has made a significant contribution towards these goals. ILs have many beneficial properties including non-volatility, non-flammability, and a large stable liq ....The Development of Novel Task Specific and Biodegradable Ionic Liquids. The advance of ?Green Chemistry? has become a forefront issue in mainstream chemistry. Green Chemistry is aimed at the reduction or elimination of hazardous substances in the design, manufacture and application of chemical products. The advent of ionic liquids (ILs) has made a significant contribution towards these goals. ILs have many beneficial properties including non-volatility, non-flammability, and a large stable liquid range. As ILs advance from academic curiosities to industrial solvents, the need to address the issue of their biodegradability and toxicity is paramount. The key objective of this project is to design new biodegradable and task specific ILs for environmentally friendly industrial use.Read moreRead less
An innovative wastewater treatment system for the removal of persisting organic pollutants (POPs). Photocatalysis is an emerging technology in wastewater treatment that is capable of completely converting POPs into harmless compounds. In this research, we will combine the expertise of Gwangju Institute of Science and Technology (GIST) in water reuse technologies, and Chonnam National University (CNU) in advanced oxidation processes with that of UTS' in physico-chemical treatment processes to dev ....An innovative wastewater treatment system for the removal of persisting organic pollutants (POPs). Photocatalysis is an emerging technology in wastewater treatment that is capable of completely converting POPs into harmless compounds. In this research, we will combine the expertise of Gwangju Institute of Science and Technology (GIST) in water reuse technologies, and Chonnam National University (CNU) in advanced oxidation processes with that of UTS' in physico-chemical treatment processes to develop a novel photocatalysis hybrid system. Through long term collaboration we aim to: (i) establish an innovative hybrid system for POPs removal, (ii) prepare industry grants, (iii) research training of postgraduate research students, and (iv) help to commercialize our research outcomes for domestic benefit and export.Read moreRead less