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Identifying Novel Targets To Treat And Prevent Diabetic Complications
Funder
National Health and Medical Research Council
Funding Amount
$697,209.00
Summary
Diabetes is the leading cause for kidney failure requiring dialysis or transplantation. Diabetic patients also have a higher risk to suffer from heart attacks, stroke and amputations in particular once kidney damage occurs. Current strategies fail to completely protect patients from complications. My research will uncover knowledge gaps in our understanding of diabetes complications, identify new targets ultimately leading to urgently needed more effective treatments and prevention strategies to ....Diabetes is the leading cause for kidney failure requiring dialysis or transplantation. Diabetic patients also have a higher risk to suffer from heart attacks, stroke and amputations in particular once kidney damage occurs. Current strategies fail to completely protect patients from complications. My research will uncover knowledge gaps in our understanding of diabetes complications, identify new targets ultimately leading to urgently needed more effective treatments and prevention strategies to reduce the burden of disease in diabetes.Read moreRead less
Personalised Exercise As Medicine. Optimising The Prescription To Maximise The Benefit
Funder
National Health and Medical Research Council
Funding Amount
$772,490.00
Summary
Humans have never been less physically active than in contemporary Western society. These studies will provide an evidence-basis to address the inactivity epidemic by laying the foundation for personalised and effective exercise prescriptions, to which people are more likely to adhere.
Although the major risk factors for cardiovascular diseases have been known for decades, and modern-day treatment is much advanced, the importance of these diseases persists, such that they remain the number one killer in Australia. This suggests that more can be done to correctly identify those at high and moderate risk of future disease, so as to optimize advice and medical treatment. This project will use the best evidence available to develop new methods of risk prediction and prevention.
Growing The Evidence Base For Improved Outcomes In Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$697,209.00
Summary
One in eight Australians has kidney disease, and is at increased risk of kidney failure, heart disease and stroke, and premature death. Despite this, very few treatments have been proven to be be effective at improving these outcomes. Professor Perkovic will undertake a suite of high-quality randomised trials and systematic reviews that will reliably identify new treatment approaches that will result in better quality and quantity of life for the millions of Australians affected by kidney diseas ....One in eight Australians has kidney disease, and is at increased risk of kidney failure, heart disease and stroke, and premature death. Despite this, very few treatments have been proven to be be effective at improving these outcomes. Professor Perkovic will undertake a suite of high-quality randomised trials and systematic reviews that will reliably identify new treatment approaches that will result in better quality and quantity of life for the millions of Australians affected by kidney diseaseRead moreRead less
Reducing Disparities In Heart Disease-Related Morbidity And Mortality: Optimising Prevention And Management
Funder
National Health and Medical Research Council
Funding Amount
$826,854.00
Summary
Heart disease contributes to a large but potentially preventable burden of death and disability. This burden is uneven with particularly vulnerable/at risk groups - including those living in regional areas and developing countries, Indigenous Australians and older patients with chronic heart disease. Prof. Simon Stewart will lead national/international collaborations to undertake innovative, multidisciplinary, prevention and disease management programs to reduce the impact and burden of heart di ....Heart disease contributes to a large but potentially preventable burden of death and disability. This burden is uneven with particularly vulnerable/at risk groups - including those living in regional areas and developing countries, Indigenous Australians and older patients with chronic heart disease. Prof. Simon Stewart will lead national/international collaborations to undertake innovative, multidisciplinary, prevention and disease management programs to reduce the impact and burden of heart disease in these vulnerable groups.Read moreRead less
Understanding Lymphatic And Vascular Biology For Application To Human Disease
Funder
National Health and Medical Research Council
Funding Amount
$697,209.00
Summary
This research is designed to provide further understanding of the role that the blood and lymphatic vessels plays in human disease. The proposal will use advanced molecular and cell biological approaches to define new diagnostic and therapeutic targets for human disease.
I am a matrix biologist determining the molecular mechanisms and novel therapeutic targets for fibrosis (tissue scarring). In particular, my research, which has a strong translational focus, is involved with elucidating the anti-fibrotic potential of the relaxin peptide-hormones (either alone or as an adjunct therapies to existing/other novel treatments) – as a means of developing therapeutic strategies for the treatment of cardiac and renal fibrosis.
The Role Of Oxidative Processes In Atherosclerosis And Related Diseases
Funder
National Health and Medical Research Council
Funding Amount
$966,135.00
Summary
Atherosclerosis and related cardiovascular disease (CVD) remains the single major cause of death and burden to health in Australia. Currently available drugs reduce the known risk factors for CVD (e.g., blood pressure, cholesterol). However, there is a need to develop novel drugs that protect in ways other than decreasing risk factors. This Fellowship will enable us to extend our basic studies on atherogenesis, with a focus on the role of oxidative processes, and to translate our key findings in ....Atherosclerosis and related cardiovascular disease (CVD) remains the single major cause of death and burden to health in Australia. Currently available drugs reduce the known risk factors for CVD (e.g., blood pressure, cholesterol). However, there is a need to develop novel drugs that protect in ways other than decreasing risk factors. This Fellowship will enable us to extend our basic studies on atherogenesis, with a focus on the role of oxidative processes, and to translate our key findings into novel therapeutics and diagnostics.Read moreRead less
Enzymes that generate or degrade peptides serve important roles - alterations in their activity can impact on a diverse range of physiological processes in healthy and diseased states. Angiotensin is a peptide that plays a critical role in regulating blood pressure and fluid balance - drugs that block the activity of its processing enzymes forms an important class of medication used to treat hypertension and heart disease. My research interest is in discovering novel roles for these enzymes.
Understanding And Overcoming Cardiovascular And Diabetes Inequalities In Indigenous Australians
Funder
National Health and Medical Research Council
Funding Amount
$707,370.00
Summary
Aboriginal and Torres Strait Islanders experience the highest rates of heart disease and diabetes of all Australians. The reasons for this large disparity is not yet fully understood. I propose to investigate the patterns, causes, complications and links between heart disease and diabetes in Indigenous populations to identify better ways of managing and preventing chronic disease in high risk communities.