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The Protective Effects Of Fenofibrate In Diabetes-related Susceptibility To Ischaemia
Funder
National Health and Medical Research Council
Funding Amount
$630,571.00
Summary
Blood flow reduction (blockage of arteries) to local tissue is a common problem for diabetic people. Fenofibrate, a cholesterol lowering drug, dramatically reduces the diabetes-related limb amputation and other vascular disorders. We plan to study the mechanism of fenofibrate to facilitate growth of new blood vessels to sites affected by vascular disease. Ultimately, this may result in new treatment for diabetic vascular complications.
Diabetic complications are the major cause of the medical burden of both type 1 and type 2 diabetes. It appears that prior episodes of poor sugar control have a sustained impact by continuing to damage blood vessels and the kidney, this phenomenon is known as metabolic memory. In this study an enzyme called Set 7 which modifies the proteins wrapping DNA is considered to play a central role in this phenomenon and could be a potential target for developing new treatments to reduce the burden of di ....Diabetic complications are the major cause of the medical burden of both type 1 and type 2 diabetes. It appears that prior episodes of poor sugar control have a sustained impact by continuing to damage blood vessels and the kidney, this phenomenon is known as metabolic memory. In this study an enzyme called Set 7 which modifies the proteins wrapping DNA is considered to play a central role in this phenomenon and could be a potential target for developing new treatments to reduce the burden of diabetic complications.Read moreRead less
M-PreM Study: Reproductive Factors, From Menarche To Pre-menopause, And The Risk Of Cardiometabolic And Respiratory Conditions Before Menopause
Funder
National Health and Medical Research Council
Funding Amount
$1,366,831.00
Summary
This study will investigate links between reproductive factors and body size of premenopausal women with their risk of major chronic conditions, such as cardiovascular disease, diabetes, and asthma. It builds on two decades of survey data from Australia’s flagship study of women’s health with a new biomedical assessment. Findings will guide the use of indicators of women’s reproductive health as a trigger for early and targeted approaches for chronic disease prevention.
Investigation Of A Novel Mechanism Causing Platelet Hyperactivity In Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$583,015.00
Summary
Diabetes represents a serious global health crisis, set to explode over the next few decades. A large proportion of deaths associated with Diabetes can be attributed to a high incidence of cardiovascular disease, with diabetic platelets shown to be ‘hyperactive’. We have defined a novel pathway sensitive to the shear forces of blood flow, which leads to platelet hyperactivity in diabetics. We will investigate potential ways to dampen this pathway, which may offer promise as novel treatments for ....Diabetes represents a serious global health crisis, set to explode over the next few decades. A large proportion of deaths associated with Diabetes can be attributed to a high incidence of cardiovascular disease, with diabetic platelets shown to be ‘hyperactive’. We have defined a novel pathway sensitive to the shear forces of blood flow, which leads to platelet hyperactivity in diabetics. We will investigate potential ways to dampen this pathway, which may offer promise as novel treatments for diabetic patients.Read moreRead less
Angiotensin II AT2 Receptor In Diabetic Atherosclerosis
Funder
National Health and Medical Research Council
Funding Amount
$477,472.00
Summary
Activation of the angiotensin 2 receptor may have effects leading to large artery disease in diabetes. We will investigate the role of the AT2 receptor in diabetes using knockout animals, novel blockers and activators and most importantly the role of the AT2 receptor in macrophages in diabetes.
Stress-induced Disease Risk For Pregnant Mothers Born Small
Funder
National Health and Medical Research Council
Funding Amount
$613,124.00
Summary
This proposal addresses the likelihood that mothers born small and exposed to stress during pregnancy will develop adverse physiological adaptations to pregnancy, slowing placental and fetal growth, programming intergenerational disease and compromising maternal health later in life. The outcomes from our human and rat studies will enable development of diagnostic tests to identify pregnancies at greater risk and lead to therapies to reduce adverse intergenerational and long-term health effects.
Novel Aspects Of The Renin Angiotensin System In Cardio-renal Disease
Funder
National Health and Medical Research Council
Funding Amount
$497,330.00
Summary
Cardiovascular disease and chronic kidney disease are major public health problems with increasing incidence and prevalence in Australia. There are complex causal relationships between these diseases, and each of them may be caused by or be a complication of the other. This proposal will investigate the role of an important hormone system, the renin angiotensin system, in experimental models and in patients with heart and kidney disease. The results may identify novel markers in the blood that c ....Cardiovascular disease and chronic kidney disease are major public health problems with increasing incidence and prevalence in Australia. There are complex causal relationships between these diseases, and each of them may be caused by or be a complication of the other. This proposal will investigate the role of an important hormone system, the renin angiotensin system, in experimental models and in patients with heart and kidney disease. The results may identify novel markers in the blood that can predict if someone will develop kidney disease.Read moreRead less
Investigating The Mechanisms That Increase Nerve-evoked Vasoconstriction Following Spinal Cord Injury
Funder
National Health and Medical Research Council
Funding Amount
$372,547.00
Summary
People with spinal cord injury not only lose control of their arms and legs but also lose control of their bladder and bowel. They also have poor control of blood pressure and an overfull bladder or bowel can lead to dangerously high blood pressure. In this project, we are investigating how this abnormal high blood pressure is generated. The aim is to develop treatments which target the mechanisms which increase the blood pressure responses elicited by the bladder and bowel.
A Comprehensive Assessment Of Diabetes In The Urban Community Of Fremantle
Funder
National Health and Medical Research Council
Funding Amount
$1,715,384.00
Summary
In the Fremantle Diabetes Study Phase I, detailed data were obtained from a community-based patient cohort between 1993 and 2001. There is strong evidence that diabetes in Australia is changing rapidly. To provide up to date data to health care providers and government, to confirm observations made in Phase I and to venture into new areas, Phase II began in 2008. We plan to extend Phase II for a further 5 years by following all 1,732 patients to achieve at least 6 years of comprehensive assessme ....In the Fremantle Diabetes Study Phase I, detailed data were obtained from a community-based patient cohort between 1993 and 2001. There is strong evidence that diabetes in Australia is changing rapidly. To provide up to date data to health care providers and government, to confirm observations made in Phase I and to venture into new areas, Phase II began in 2008. We plan to extend Phase II for a further 5 years by following all 1,732 patients to achieve at least 6 years of comprehensive assessment.Read moreRead less
The Influence Of Anaesthetic Depth On Patient Outcome After Major Surgery
Funder
National Health and Medical Research Council
Funding Amount
$2,893,795.00
Summary
Millions of high-risk patients have general anaesthesia for major surgery worldwide every year, but the optimal depth of anaesthesia for these patients is not known. The aim of this large randomised trial is to determine the impact of light versus deep general anaesthesia on survival at one year postoperatively in 6,500 older patients. If light anaesthesia is associated with better survival, this result will be immediately implementable, will save lives and will reduce the costs of care.