Inhibitors Of Secretory Phospholipases In Diet Induced Obese Rats
Funder
National Health and Medical Research Council
Funding Amount
$581,051.00
Summary
A new drug given to rats fed a high fat-carbohydrate diet shows very promising effects in preventing and treating abdominal obesity, insulin resistance, glucose intolerance, and other risk factors for diabetes and cardiovascular disease. This project will profile biochemical and pharmacological properties of the drug in more detail in order to track down molecular mechanisms of its action and potential therapeutic benefits, guided by studies on rats, biochemical markers, rat and human fat cells.
Gene Variants In Adiponectin And Its Receptors As Risk Factors For Metabolic And Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$534,107.00
Summary
Obesity has a major impact on the development of metabolic syndrome (MetS), type 2 diabetes (T2D), and cardiovascular disease (CVD). It is important to identify the molecular links between obesity and these conditions. Adiponectin, an adipocyte-specific hormone, is a likely molecular candidate because of its pleiotropic metabolic actions. We will investigate the role of adiponectin, the variants within its gene ADIPOQ, and that of its two receptors, in the development of MetS, T2D, and CVD.
With particular interest in developing data analysis techniques, I am an epidemiologist assessing risk factors and developing risk calculators for non-communicable diseases, such as cardiovascular disease and diabetes, in Aboriginal people.
Echocardiographic Predictors Of Cardiovascular Outcomes And Their Progression In Diabetes Mellitus
Funder
National Health and Medical Research Council
Funding Amount
$104,664.00
Summary
Premature cardiovascular (CV) disease is the most common cause of death in diabetes, and the risk persists even after adjustment for traditional risk factors. We aim to assess the prevalence and predictors of CV disease in type 2 diabetes (DM). Additionally we will assess the prognostic utility of potential plasma biomarkers and echocardiography, perform a 8-year outcome analysis.
Obesity, Pre-diabetes And Future Risk Of Diabetes: Maximising The Evidence, Minimising The Cost
Funder
National Health and Medical Research Council
Funding Amount
$470,136.00
Summary
The overarching aim of this proposal is to reliably determine how best to identify people at high risk of developing future diabetes. We will do this by using information on biological and behavioural risk factors that was collected on nearly 200,000 people many years ago and who were subsequently followed up to see who developed diabetes. This information will be used to create a risk prediction tool for spotting individuals most at risk of developing diabetes at some point in the future.
Inter-relationships Between Life-stage Transitions, Depression And Cardio-metabolic Health In Young Adults
Funder
National Health and Medical Research Council
Funding Amount
$360,325.00
Summary
This study will investigate how social transitions and depression in young Australian adults affect the development of obesity and the adoption or persistence of behaviours that are associated with the risk of heart disease and diabetes. These behaviours include smoking, poor diet, physical inactivity and alcohol consumption. A better understanding of how psychosocial factors influence risk factors for heart disease and diabetes is needed to improve prevention strategies.
Follow Up Of The 1985 Australian Schools Health And Fitness Survey Cohort
Funder
National Health and Medical Research Council
Funding Amount
$2,309,456.00
Summary
This study provides a unique opportunity to follow up a cohort of children on which an extensive range of physical and lifestyle measures were made in 1985. This study has the capacity to find out whether childhood lifestyle and physical measures are related to the risk of heart disease, diabetes and other common health problems in adulthood.
FIELD LIFE: Lifestyle Interactions In Fenofibrate And The Epigenome
Funder
National Health and Medical Research Council
Funding Amount
$1,071,754.00
Summary
Genetic and environmental factors influence the risks of developing the blood vessel (vascular), eye and kidney complications of diabetes, but how extensively these factors interact is less well understood. We will examine blood levels of a new class of regulatory molecules (called microRNAs), and of DNA damage and identify how they are linked to vascular risk factors, and heart, foot, eye and kidney damage in 2000 well-characterised Australians with type 2 diabetes from the FIELD Study.