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Long-term Health Effects Of Low-carbohydrate Diets In Obese Subjects With The Metabolic Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$497,716.00
Summary
The prevalence of obesity and its associated physiological and psychological comorbidities is increasing dramatically in Australia and throughout the developed world. Governing public health bodies recommend lifestyle changes of energy restriction combined with increasing physical activity for the treatment of obesity. In response to the increasing concerns about the rising level of obesity, there has been a multitude of fad diets developed outside the medical and nutritional recommendations for ....The prevalence of obesity and its associated physiological and psychological comorbidities is increasing dramatically in Australia and throughout the developed world. Governing public health bodies recommend lifestyle changes of energy restriction combined with increasing physical activity for the treatment of obesity. In response to the increasing concerns about the rising level of obesity, there has been a multitude of fad diets developed outside the medical and nutritional recommendations for healthy eating and with this an increased popularity of dietary regimens with severe restriction of carbohydrate, such as the Dr. Atkins diet. But although adopted by millions worldwide yearly and the release of a range of low-carbohydrate products into the food market, there is minimal scientific evidence available for the long-term efficacy and safety of low-carbohydrate diets, including their impact on risk factors for cardiovascular disease, diabetes, cancer, kidney function, bone health, psychosocial function and the capacity to undertake concurrent physical activity and daily living activities. Consequently, there is a lack of evidenced-based public health recommendations and policy regarding these dietary practices. In this project we will compare the long-term nutritional adequacy and effects of a very low-carbohydrate, weight loss diet to a conventional high-carbohydrate, low fat weight loss diet on cardiovascular health, exercise tolerance, mood state, bone health, renal function, bowel health and cancer risk in obese people with risk factors for cardiovascular disease in order to develop appropriate public health guidelines to counsel obese patients.Read moreRead less
Therapeutic Regulation Of Hepatic Steatosis And Lipid Transport In The Metabolic Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$522,435.00
Summary
Obesity is an increasing problem in Australia. Elevated fat levels in the liver and blood are associated with obesity and increased risk for heart disease. In this project, we will demostrate new mechanisms of action of Pioglitazone (an insulin-sensitizing agent) and Omacor (fish oils) that will complement the favourable efect of weight loss in the treatment of elevated blood fats and reduction in risk of heart disease in an important groups of subject in the population.
Australian Stroke Genetics Collaborative - Genome-wide Association Study In Ischaemic Stroke
Funder
National Health and Medical Research Council
Funding Amount
$1,141,037.00
Summary
The majority of stroke is caused by atherothrombosis, the formation of blood clots in brain blood vessels. Numerous genes are linked to atherothrombosis, but many studies examined genetic influences in isolation from environmental risk factors. We will examine the relevance of genetic variations linked to atherothrombosis, in the context of environmental risk factors. By determining the contribution of genetic and environmental factors in stroke, we will develop a stroke risk assessment tool.
Pathogenic Vibrio Parahaemolyticus In Australian Oysters
Funder
Fisheries Research and Development Corporation
Funding Amount
$13,995.00
Summary
In 1999, Seafood Services Australia (SSA) initiated a risk-based approach to assessing and managing hazards. Regarding oysters, two risk assessments were undertaken, one on viruses and one on vibrios. Focusing on the latter hazards, the risks associated with the three main species: V. parahaemolyticus, V. vulnificus and V. cholerae were assessed. It was noted that V. parahaemolyticus (Vp) has recently caused major outbreaks in USA from consumption of oysters due to a “new” pathogenic type O3:K6. ....In 1999, Seafood Services Australia (SSA) initiated a risk-based approach to assessing and managing hazards. Regarding oysters, two risk assessments were undertaken, one on viruses and one on vibrios. Focusing on the latter hazards, the risks associated with the three main species: V. parahaemolyticus, V. vulnificus and V. cholerae were assessed. It was noted that V. parahaemolyticus (Vp) has recently caused major outbreaks in USA from consumption of oysters due to a “new” pathogenic type O3:K6. For Australia, no work on pathogenic Vp in oysters could be found, which introduced a great deal of uncertainty to the assessment. The RA noted that there had been two Vp poisonings in NSW from prawns imported from Indonesia, the clear inference being that pathogenic Vp exists in neighbouring waters.
In March, 2002 the FAO/WHO team will develop a global risk assessment of Vp in oysters. The RA will utilise the US risk model and insert data from the oyster industries of Canada, New Zealand, Australia and Japan. If no Australian data are available on levels of Vp the modellers will make assumptions which may well be disadvantageous to the Australian industry. This could happen if the north American mitigation strategy (rapid icing) to control of Vp is adopted as a prerequisite for export.
Failure to input Australian data into a Codex global risk assessment could have serious consequences for the industry. At best it would lead to protracted negotiation between Australia and Codex. These negotiations would need to be science-based and a research program would need to be funded. It is probable that the scale of this investigation would be at least a log scale larger than the present application.
Among the strategies to mitigate V. parahaemolyticus risk is chilling oysters as early as possible after harvest. In the case of the Canadian industry in British Columbia, the strategy has been used successfully in the summers of 2000 and 2001. This strategy is directly opposed to current summer handling practices by the NSW industry which allows product to remain as warm as 25°C for up to three days.
This project is designed to provide evidence of the occurrence and prevalence of pathogenic and non-pathogenic V. parahaemolyticus in Australian oysters. This knowledge will be invaluable to the NSW industry in particular - in case the FAO/WHO assessment recommends chilling of oysters as a pre-requisite for market access.
Effect of not doing the proposed study
If the work is not done and Codex Committee on Food Hygiene (CCFH) recommend a mitigation strategy of rapid icing, the local industry has a number of choices:
1. Ignore the CCFH recommendation on the grounds that we don’t export large volumes of oysters. The problem with this approach is that Codex has just as much application and force for domestic production as it does in the export arena.
2. Undertake a study to try to show that there is no problem with V. parahaemolyticus from Australian product. This would probably be a larger study than the present one and would be mounted to attempt to gain exemption for Australia. It’s always difficult to unwind global hygiene edicts.
The present project, for a relatively modest investment, effectively places Australian data into a global risk assessment. As such the data will have great force in the modelling phase. xbad Objectives: 1. Obtain total Vibrio spp. and total V. parahaemolyticus counts from oysters from NSW, SA and Tasmania. 2. Determine prevalence of pathogenic V. parahaemolyticus amongst these isolates. 3. Compile and analyse data for potential inclusion in the FAO-WHO global risk assessment of Vibrio parahaemolyticus in oysters. Read moreRead less
Revision Of The AQUAVETPLAN Operational Procedures Manuals For Disposal And Decontamination
Funder
Fisheries Research and Development Corporation
Funding Amount
$31,500.00
Summary
The Department of Agriculture and Water Resources is seeking expressions of interest for the revision of the following AQUAVETPLAN Operational Procedures manuals: 1. Decontamination 2. Disposal The Australian Aquatic Veterinary Emergency Plan (AQUAVETPLAN) is a series of manuals that outline Australia’s approach to national disease preparedness and propose the technical response and control strategies to be activated in a national aquatic animal disease emergency.
The Decont ....The Department of Agriculture and Water Resources is seeking expressions of interest for the revision of the following AQUAVETPLAN Operational Procedures manuals: 1. Decontamination 2. Disposal The Australian Aquatic Veterinary Emergency Plan (AQUAVETPLAN) is a series of manuals that outline Australia’s approach to national disease preparedness and propose the technical response and control strategies to be activated in a national aquatic animal disease emergency.
The Decontamination manual was first published in 2008, and the second version of the Disposal manual was published in 2009. Both manuals require revision to reflect new scientific knowledge, and to ensure that decontamination and disposal procedures used for disease control purposes reflect current ‘best-practice’ approaches. Objectives: 1. Review and deliver updated AQUAVETPLAN Operatinal Procedures Manuals for decontamination and disposal. Read moreRead less
Understanding Ethnic Differences In The Relationships Between Cardiovascular Risk Factors And Cardiovascular Disease In High Risk Populations
Funder
National Health and Medical Research Council
Funding Amount
$151,374.00
Summary
Cardiovascular disease (disease of the heart and blood vessels) is the leading cause of death world-wide. However, the burden of this disease is significantly greater in some populations, including Indigenous Australians and South Asians (Indians, Pakistanis or Bangladeshis). This project therefore aims to improve our understanding of CVD risk in these populations, and to develop better clinical assessment tools that will assist in the early detection and management of CVD in these individuals.