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Understanding Ethnic Differences In The Relationships Between Cardiovascular Risk Factors And Cardiovascular Disease In High Risk Populations
Funder
National Health and Medical Research Council
Funding Amount
$151,374.00
Summary
Cardiovascular disease (disease of the heart and blood vessels) is the leading cause of death world-wide. However, the burden of this disease is significantly greater in some populations, including Indigenous Australians and South Asians (Indians, Pakistanis or Bangladeshis). This project therefore aims to improve our understanding of CVD risk in these populations, and to develop better clinical assessment tools that will assist in the early detection and management of CVD in these individuals.
Monitoring cardiovascular risk is a major part of the clinical workload both in general practice and specialty areas, but it is an under-researched area, reflected in a general lack of evidence based guidelines. My research will evaluate how to optimise the monitoring of cardiovascular risk both before and after starting treatment. By maximising clinical benefits for patients and minimising unnecessary resource use, my research will benefit patients, clinicians and the community at large.
Large-Scale Multi-Omic Analysis And Risk Prediction Of Complex Human Disease
Funder
National Health and Medical Research Council
Funding Amount
$321,414.00
Summary
A major aim of medicine is to prevent disease, which is often more successful and cost-effective than treating an already existing condition. Common diseases, such as autoimmune and cardiovascular diseases, have a predisposing genetic basis. We will conduct genetic analysis of large datasets of coeliac disease and cardiovascular disease to better identify individuals at increased risk and to better understand the underlying biological processes through which genetics act to affect one's risk.
The Burden And Risk Factors Of Depressive Disorders In Indigenous Australians: Implications For Early Detection And Prevention
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This Fellowship addresses the high rates of depression amongst Indigenous Australians. The proposed work will quantify the extent to which two major risk factors contribute to the burden of depression in this population and the burden avertable from interventions to modify these risk factors. Findings would inform resource allocation and health service delivery, and in doing so, present opportunities for improvements in the health of Indigenous Australians.
Determining Current And Future Populations At Risk Of Cardiovascular Disease Using Applied Geographic Information (GIS).
Funder
National Health and Medical Research Council
Funding Amount
$332,713.00
Summary
This unique and innovative project has the potential to deliver a powerful tool to both highlight and combat the burden of CVD in Australia. Key outcomes include,the ability to identify geographical ‘hotspots’ where there is likely to be a mismatch between demand for and actual provision of cardiovascular services and where new hotspots are likely to emerge requiring increased resources and services as a result of the ageing and increasing risk factors such as diabetes and obesity.
Defining An Effective Cardiovascular Risk Stratification System For Children
Funder
National Health and Medical Research Council
Funding Amount
$295,450.00
Summary
This project combines information from four large studies that have been carried out in Australia, the United States, and Finland that have collected measures on the same participants during childhood and again during adulthood, to determine an effective means of identifying children at risk of developing premature cardiovascular disease.
Central Mechanisms Underlying Obesity Related Hypertension.
Funder
National Health and Medical Research Council
Funding Amount
$311,860.00
Summary
The prevalence of obesity and related disease are rising rapidly worldwide. Adult risk factors, genetic predisposition and socioeconomic factors all contribute to obesity and obesity related hypertension however there is compelling evidence that the early life environment also contributes to disease progression. In this regard, an understanding of how increased sympathetic activity occurs in programmed hypertension is required in order to develop effective therapeutic strategies.
Societal Determinants Of Cardiovascular Risk Factors And Disease In Communities In Low, Middle And High Income Countries
Funder
National Health and Medical Research Council
Funding Amount
$377,845.00
Summary
The type of neighbourhood- society we live in is increasingly recognised as importantly influencing our behaviour such as our physical activity or nutrition and therefore our health, but no comprehensive measure of societal profile exists. This research aims to devise and test a comprehensive community-profiling tool to measure these factors. This will enable communities to measure their local environment for factors that increase the risk of developing cardiovascular risk factors and disease.
Elucidation Of The Genetic Mechanisms Of Primary Aldosteronism: The Most Common, Curable Form Of Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$334,338.00
Summary
Hypertension is a major cardiovascular risk factor that affects 10-40% of the population. The steroid hormone aldosterone controls blood pressure and plays a significant role in hypertension. Primary Aldosteronism (PAL), a condition caused by the excessive production of aldosterone, is the most common, curable form of hypertension. I will identify the molecular mechanisms responsible for PAL, to advance the development of new diagnostic tools and identification of novel therapeutic targets.