Molecular And Structural Determinants Of Myocardial Dysfunction And Prognosis In Left And Right Heart Failure.
Funder
National Health and Medical Research Council
Funding Amount
$124,608.00
Summary
The aim of this research is to investigate the role of inherited genetic variation on myocardial function and prognosis in patients with cardiomyopathies as well as pulmonary hypertension. Clinical, cardiac genomic and myocardial tissue studies will be undertaken in various patient cohorts. It is hoped that this research will provide new insights into disease mechanisms, and will contribute to new approaches to patient management and risk stratification.
Investigating Friedreich Ataxia Cardiomyopathy And Ophthalmopathy Using Induced Pluripotent Stem Cells
Funder
National Health and Medical Research Council
Funding Amount
$136,205.00
Summary
There is no effective treatment for Friedreich ataxia (FRDA). Patients, usually diagnosed as children, will end up in wheelchairs; many have difficulty with movement, speech, develop eye problems and diabetes. Most die at a young age from heart failure. In this project we will study stem cells from patients with FRDA. In the laboratory, these stem cells will be turned into heart and eye cells to study why patients with FRDA develop symptoms and to help develop new drugs to provide effective trea ....There is no effective treatment for Friedreich ataxia (FRDA). Patients, usually diagnosed as children, will end up in wheelchairs; many have difficulty with movement, speech, develop eye problems and diabetes. Most die at a young age from heart failure. In this project we will study stem cells from patients with FRDA. In the laboratory, these stem cells will be turned into heart and eye cells to study why patients with FRDA develop symptoms and to help develop new drugs to provide effective treatment.Read moreRead less