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Fetal Cardiovascular Development And The Impact Of Chronic Hypoxia And Fetal Growth Restriction
Funder
National Health and Medical Research Council
Funding Amount
$307,232.00
Summary
Low birth weight occurs in 7% of Australian babies and is associated with an increased risk of cardiovascular disease in adult life. Understanding the mechanisms underlying heart and blood vessel development in low birth weight babies will lead to improved identification and intervention in those individuals at risk of cardiovascular disease in adult life, improving heart health for Australians. Reducing cardiovascular disease will improve both quality and quantity of life for Australians.
Low back pain affects one in four people in Australia and is responsible for over $8 billion spent on treatments and work loss every year. Surgery is a popular treatment approach for this multifactorial condition but we still lack high quality science to support the role of surgery for low back pain. We also lack research capacity in this field. In my fellowship, I propose to conduct high quality studies to generate and implement scientific knowledge in this field.
Refining Methods For Obtaining, Synthesising And Interpreting Research Evidence In Surgery
Funder
National Health and Medical Research Council
Funding Amount
$314,312.00
Summary
Research evidence plays a crucial role in improving clinical care. However the main forms of evidence and the tools that facilitate evidence use - namely randomised controlled trials (RCT) and structured systematic reviews of existing research - have had limited application in surgery for a variety of reasons. This project aims to promote the use of research evidence in surgical decision making by developing tools tailored to the predominance of non-RCTs in surgery and surgeons' information need ....Research evidence plays a crucial role in improving clinical care. However the main forms of evidence and the tools that facilitate evidence use - namely randomised controlled trials (RCT) and structured systematic reviews of existing research - have had limited application in surgery for a variety of reasons. This project aims to promote the use of research evidence in surgical decision making by developing tools tailored to the predominance of non-RCTs in surgery and surgeons' information needs.Read moreRead less
Using Human 3D Engineered Heart Tissue For Discovery Of Novel Biology And Novel Therapeutics
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
The goal of this project is to develop a model of miniaturised 3D human heart tissue for research into cardiac biology and also drug discovery applications. This will hopefully result in better, cheaper drugs in the future with less reliance on animal testing.
Role Of Non-Invasive Imaging Using Speckle Tracking Echocardiography In The Identification And Treatment Of Patients At Risk Of Arrhythmias And Consequent Sudden Cardiac Arrest
Funder
National Health and Medical Research Council
Funding Amount
$437,034.00
Summary
Every year, 15,000 Australians die from sudden cardiac arrest. Identifying individuals at risk is a major challenge. We will investigate whether a heart ultrasound technique called speckle tracking allows clinicians to rapidly identify changes in heart muscle that are associated with cardiac arrest. If found to be positive, the technique may be broadly applied to large populations, identifying at risk individuals, potentially rescuing them before cardiac arrest occurs.
Characterisation Of Sub-clinical Cardiac Dysfunction Using Novel Cardiac Exercise Imaging
Funder
National Health and Medical Research Council
Funding Amount
$429,552.00
Summary
Heart failure is caused by heart muscle weakness and is associated with reduced quality of life and survival. Identification of heart failure in its earliest stages provides clinicians with an opportunity to institute preventative measures and prevent patients from developing symptoms. This project utilises novel ultrasound and magnetic resonance imaging techniques performed during exercise to identify heart muscle weakness at its earliest stage.