The Role Of CD4+ T-helper Cells In The Generation, Maintenance And Activation Of A Long Lasting Anti-tumour CTL Effect.
Funder
National Health and Medical Research Council
Funding Amount
$247,383.00
Summary
In this research project we will be studying the mechanisms how a long-lasting anti-cancer response could be achieved by vaccination. This information not only will help to design better vaccines against cancers, but also will help to design better vaccines against viral diseases.
Pathogenic Flaviviruses: Molecular Mechanisms Of Disease, Host Response And Vaccines
Funder
National Health and Medical Research Council
Funding Amount
$697,209.00
Summary
The application is aimed at advancing our understanding of the viral and host processes determining outcome of infection with pathogenic flaviviruses (i.e. West Nile virus) to the level allowing most comprehensive design of effective vaccines and anti-viral drugs. One of the aims is also to develop novel viral delivery vectors for cancer therapy based on self-replicating RNA of an attenuated Australian strain of West Nile virus, Kunjin.
I am a structural biologist investigating the structure and function of malaria surface proteins as vaccine candidates, regulators of cytokine signalling and pharmacologically active toxins.
Novel Vaccine Formulation For Immunotherapy Of Adenocarcinomas
Funder
National Health and Medical Research Council
Funding Amount
$178,400.00
Summary
We have designed a vaccine based on a unique delivery system. Mice immunised with vaccine were protected from a tumour challenge. We will now design a vacine with a cancer associated protein so that people once immunised can make killer cells. Since humans have different genetic makeup we will produce a vacine which is more effective and will benefit everyone. This vaccine will be more effective than a current vacine in that has yielded promising results in humans.
Self Adjuvanting CTL-Based Influenza Vaccines For Human Use
Funder
National Health and Medical Research Council
Funding Amount
$214,842.00
Summary
This project will generate novel vaccines that elicit cell-mediated immunity against influenza infection. The vaccines are totally synthetic and therefore not constrained by the limitations in manufacturing which currently confront egg-grown vaccines. These vaccines induce very strong immune responses because they target dendritic cells which are pivotal for induction of all immune responses. This targeting capability is due to a simple lipid molecule incorporated into the vaccine which is recog ....This project will generate novel vaccines that elicit cell-mediated immunity against influenza infection. The vaccines are totally synthetic and therefore not constrained by the limitations in manufacturing which currently confront egg-grown vaccines. These vaccines induce very strong immune responses because they target dendritic cells which are pivotal for induction of all immune responses. This targeting capability is due to a simple lipid molecule incorporated into the vaccine which is recognised by specific receptors on the surface of dendritic cells and also causes their maturation, a step which is essential for recognition by the immune system of potential pathogens. The technology to design and assemble these new vaccines is already.Read moreRead less
Characterisation Of The Antigen Cross-presentation Pathway In Dendritic Cells
Funder
National Health and Medical Research Council
Funding Amount
$593,888.00
Summary
T cells and Dendritic Cells (DC) are important components of the immune system. DC detect bacterial and viral infections and activate T cells to fight those infections. Our goal is to understand how DC communicate with T cells. This knowledge will allow us to develop new vaccines and to interfere with the mechanisms that enable infectious agents to escape detection.