Comparative Effectiveness Of Breast Tomosynthesis And Mammography In Real-world Population Screening: Evidence To Underpin And Improve Breast Cancer Screening
Funder
National Health and Medical Research Council
Funding Amount
$1,851,430.00
Summary
This research addresses key evidence gaps in breast cancer screening by investigating tomosynthesis (3D mammography) versus standard 2D mammography screening to establish the effectiveness of tomosynthesis in Australia and internationally, including impact on cancers not detected at screening that progress clinically. Large-scale studies will be done in real world screening services including a prospective comparative study planned collaboratively with BreastScreen to guide screening policy.
A Vision Of Healthy Urban Design For NCD Prevention
Funder
National Health and Medical Research Council
Funding Amount
$608,911.00
Summary
We are living in a new city era with new risks for health, and new ways to understand them. This project will combine state-of-the art methods in computer vision and artificial intelligence alongside co-creation of a web-based toolkit for action for use by city planners and urban designers that demonstrate practical pathways Improving our understanding of the strengths and limitations of existing city designs to ensure they are safe, clean, healthy, and sustainable.
Optimizing Immunotherapy Treatment For Breast Cancer Patients
Funder
National Health and Medical Research Council
Funding Amount
$1,938,014.00
Summary
The first steps in introducing immunotherapy for breast cancer patients have been taken in 2019. However, there is much work to do optimize immunotherapy for all breast cancer patients. My research, involving both lab and clinical trials, will develop new treatment strategies and identify new biomarkers to distinguish responders and non-responders. This will allow individualised selection of patients for evaluation of different immunotherapy approaches, with the aim of improving their survival.
Reducing Colorectal Cancer Burden In Young Adults: Precision Prevention And Early Detection
Funder
National Health and Medical Research Council
Funding Amount
$1,449,800.00
Summary
Bowel cancer rate in young adults before age 50 is increasing worldwide including Australia. Since it is impossible to screen everyone, it is critical to identify who is likely to develop the disease, to optimise screening. Using the world's largest resource for young-onset bowel cancer, I will conduct studies to generate high-quality evidence to inform how to best prevent bowel cancer in young adults and translate into the policy and practice, to reduce colorectal cancer burden in young adults.
Growth Regulatory Transcriptional Networks And Novel Therapies In Vascular Pathobiology
Funder
National Health and Medical Research Council
Funding Amount
$576,760.00
Summary
Cardiovascular disease and cancer together account for the majority of all deaths. Underpinning both these conditions are cellular and molecular changes in our blood vessels. This Fellowship will enable Professor Khachigian to enhance our understanding of fundamental mechanisms regulating the pathogenesis of vascular disease, and by harnessing this new knowledge in preclinical and human trials, generate novel strategies to combat a range of diseases through strategic partnership, collaboration a ....Cardiovascular disease and cancer together account for the majority of all deaths. Underpinning both these conditions are cellular and molecular changes in our blood vessels. This Fellowship will enable Professor Khachigian to enhance our understanding of fundamental mechanisms regulating the pathogenesis of vascular disease, and by harnessing this new knowledge in preclinical and human trials, generate novel strategies to combat a range of diseases through strategic partnership, collaboration and training.Read moreRead less
Creating Treatment Options For Endometrial Cancer Through High-level Clinical Trials
Funder
National Health and Medical Research Council
Funding Amount
$2,508,156.00
Summary
Endometrial cancer (EC) arises from the inner lining of the womb. Treatment typically involves surgery (hysterectomy) to remove the womb and explore if cancer has affected the lymph glands in the pelvis. The benefit of surgery on the lymph glands is doubtful. My research program will generate evidence to inform clinical practice on the treatment of EC and explore non-surgical treatment alternatives to a hysterectomy for better patient outcomes, particularly in women who wish to start a family.