Inherited determinants of cancer aetiology. Family history of cancer is a strong risk factor for many cancers. This project will aim to identify inherited factors influencing risk of developing cancer and those factors influencing the course of the disease and outcomes.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100006
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
An adaptable and dedicated linear accelerator for medical radiation research. Leading radiation scientists developing innovative methods and devices for treating cancer patients will collaborate in future research using this highly adaptable linear accelerator for medical radiation research. Innovations in tumour targeting, better patient safety, new medical devices and improved cancer outcomes are expected.
Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.
Efficacy Of Education And Advice Delivered By Text Message To Aid Smoking Cessation
Funder
National Health and Medical Research Council
Funding Amount
$538,395.00
Summary
A high proportion of smokers indicate a desire to stop smoking and report having made attempts to quit. However, most attempts are not successful and new methods are needed to support motivated smokers and improve success rates. This project evaluates the use of text messages to deliver advice and support to smokers motivated to stop smoking. We aim to understand if and how this promosing new intervention helps smokers to quit.
Ultrasound in muscle vascular research, and gene therapy. This project focuses on ultrasound and microbubbles for the imaging of microvascular blood flow patterns in skeletal muscle and as a modality for drug delivery. The aim is to develop and refine technology specifically for (i) assessment of muscle microvascular flow in health and disease, and for (ii) delivery of state-of-the art gene constructs to endothelial cells that control blood flow in the muscle microvasculature. We anticipate impr ....Ultrasound in muscle vascular research, and gene therapy. This project focuses on ultrasound and microbubbles for the imaging of microvascular blood flow patterns in skeletal muscle and as a modality for drug delivery. The aim is to develop and refine technology specifically for (i) assessment of muscle microvascular flow in health and disease, and for (ii) delivery of state-of-the art gene constructs to endothelial cells that control blood flow in the muscle microvasculature. We anticipate improved technology for early diagnosis of impairment in microvascular flow relevant to muscle insulin resistance and novel therapeutics that improve muscle microvascular blood flow applicable to the treatment of diabetes.Read moreRead less
Ensuring The Utility And Sustainability Of Tissue Banks: Supporting Translational Research In Australia Through Informed Regulation And Community Engagement.
Funder
National Health and Medical Research Council
Funding Amount
$481,885.00
Summary
Tissue banks provide a critical resource for translational research into the causes and treatment of many diseases affecting children and adults, such as cancer.Their success and contribution to medical research depends on addressing the many unresolved and emerging challenges that impact their work. This is the first national empirical study engaging the Australian research community, legal experts tissue donors and the public about the challenges to tissue banks to inform ethico legal regulati ....Tissue banks provide a critical resource for translational research into the causes and treatment of many diseases affecting children and adults, such as cancer.Their success and contribution to medical research depends on addressing the many unresolved and emerging challenges that impact their work. This is the first national empirical study engaging the Australian research community, legal experts tissue donors and the public about the challenges to tissue banks to inform ethico legal regulation and deliver better health care systems.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0452281
Funder
Australian Research Council
Funding Amount
$102,900.00
Summary
Muscle Vascular Research and Gene Therapy Using Ultrasound. We seek funds to set up a national facility for ultrasound in muscle vascular research and gene therapy. Ultrasound with microbubbles will be used for the imaging of muscle microvascular blood flow and as a delivery modality for gene constructs to endothelial cells that control blood flow. The technology has application to (i) the assessment and therapeutic treatment of impaired microvascular function as in diabetics; (ii) the assessmen ....Muscle Vascular Research and Gene Therapy Using Ultrasound. We seek funds to set up a national facility for ultrasound in muscle vascular research and gene therapy. Ultrasound with microbubbles will be used for the imaging of muscle microvascular blood flow and as a delivery modality for gene constructs to endothelial cells that control blood flow. The technology has application to (i) the assessment and therapeutic treatment of impaired microvascular function as in diabetics; (ii) the assessment of adaptation to physical training and (iii) the development of therapeutic agents used to treat diabetes. We anticipate improved technology that is fully characterized and novel therapeutics that improve microvascular blood flow.Read moreRead less
From The Synchrotron To The Clinic: Translation Of A Novel Functional Lung Imaging Technology
Funder
National Health and Medical Research Council
Funding Amount
$891,834.00
Summary
Our team has recently developed a synchrotron technology with a startling capacity for dynamic functional imaging that can act as a sensitive regional indicator of lung disease. We will demonstrate that this technology can be translated from the synchrotron to the lab and eventually the clinic. We will provide proof of this concept by the application of this technology to emphysema, asthma, lung cancer, cystic fibrosis lung disease and neonatal resuscitation.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100043
Funder
Australian Research Council
Funding Amount
$389,000.00
Summary
Rapid Molecular (Bio)material Imaging by Infrared and Raman Microscopies. This project aims to undertake fast probe-free biochemical/chemical imaging of heterogeneity within cells and materials surfaces with new infrared and Raman imaging. It will generate new fundamental knowledge on: cell heterogeneity and dynamic processes; technologies for optimising cell printing; understanding toxicity of microplastics; and protocols for measuring materials of technological relevance. Expected outcomes inc ....Rapid Molecular (Bio)material Imaging by Infrared and Raman Microscopies. This project aims to undertake fast probe-free biochemical/chemical imaging of heterogeneity within cells and materials surfaces with new infrared and Raman imaging. It will generate new fundamental knowledge on: cell heterogeneity and dynamic processes; technologies for optimising cell printing; understanding toxicity of microplastics; and protocols for measuring materials of technological relevance. Expected outcomes include: interdisciplinary collaborations in new protocols for in-vitro drug development; cell printing technologies; environmental impacts of microplastics; and materials design. Expected benefits include innovative approaches to early stage drug design; improved environmental controls and advances in innovative materials.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100183
Funder
Australian Research Council
Funding Amount
$715,000.00
Summary
An ICP-ToF-MS facility for environmental, mineral and biological science. This project aims at establishing a facility for the detection, quantification and rapid mapping of elements and their isotopes in nanoparticles and a diverse set of biological and earth materials. The facility consists of a latest generation ICP-ToF-MS that can simultaneously collect a full suite of isotopic information (Li to U) from liquid samples or, in combination with laser ablation and laser induced breakdown spectr ....An ICP-ToF-MS facility for environmental, mineral and biological science. This project aims at establishing a facility for the detection, quantification and rapid mapping of elements and their isotopes in nanoparticles and a diverse set of biological and earth materials. The facility consists of a latest generation ICP-ToF-MS that can simultaneously collect a full suite of isotopic information (Li to U) from liquid samples or, in combination with laser ablation and laser induced breakdown spectroscopy, solid samples. It will enhance capabilities and sample throughput in environmental science, geoscience, biology and cultural heritage research, significantly accelerating the discovery of new ore bodies, improving environmental risk assessment and assisting research in cancer biology.Read moreRead less