Translating Risk Models To Improve Prevention And Early Diagnosis Of Cancer In Primary Care
Funder
National Health and Medical Research Council
Funding Amount
$479,882.00
Summary
Primary care plays a key role in prevention and early diagnosis of cancer. This fellowship will apply evidence about cancer risk to help GPs provide tailored advice to patients about preventing common cancers. It will also use new risk tools to assess people with symptoms suggestive of cancer to support earlier diagnosis. The research extends to studies relating to how people interpret symptoms and ways of promoting earlier presentation to the GP in patients who are at higher risk of cancer.
This Practitioner Fellowship will aim to improve outcomes in people with lung cancer. The clinical studies will focus on: 1. Using low dose CT scans to detect lung cancer at a very early stage. 2. Molecular tests to diagnose lung cancer earlier, and provide information that will be useful for deciding treatment 3. Using advanced techniques to diagnose small opacities in the lung
Stroke is a devastating disease affecting 50,000 Australians and over 5 million people globally every year. The overall aims are to develop better knowledge, better tools and more effective strategies to treat and prevent stroke. Projects include discovery of new genetic stroke risk factors, better management of recognised risk factors, trials of treatment strategies for acute stroke, and the investigation of strategies for more effective implementation of treatments.
Improving Clinical Understanding And Management Of Tendinopathy
Funder
National Health and Medical Research Council
Funding Amount
$487,621.00
Summary
Painful tendons occur in people of all ages. Treatment outcomes are variable and many people are left with chronic pain and limited capacity to be active. This research will investigate the development of tendinopathy, the cause of tendon pain and examine imaging methods to improve management. This research expects to demonstrate that tendon injury develops during puberty, that the brain has a central role in tendon pain, and that regular monitoring of tendon structure can improve outcomes.
New Approaches To The Management Of Atrial Fibrillation
Funder
National Health and Medical Research Council
Funding Amount
$577,189.00
Summary
Atrial fibrillation is the most common heart rhythm disorders and is now a common cause of hospitalisation in Australia. It can lead to devastating complications such as stroke and heart failure. This fellowship will under take a series of randomised studies to define new therapeutic strategies for management of atrial fibrillation. It aims to establish lifestyle and preventative measures into the mainstream for the management and prevention of this condition.
I am a practising hospital neurologist and world leader in the prevention and treatment of stroke. Our research aims to realise exciting new break-throughs for stroke sufferers by testing the effectiveness and safety of new treatments that promise to improve recovery of function of damaged brain and reduce disability after stroke, and to prevent recurrent strokes.
Molecular Imaging As A Critical Tool In Discovery Of The Basis Of Tumour Heterogeneity And Developing Novel Therapies To Overcome Therapeutic Resistance
Funder
National Health and Medical Research Council
Funding Amount
$467,961.00
Summary
Determining treatment options for cancer currently relies on the size and extent of tumour deposits on imaging, combined with a biopsy. However, this approach fails to recognise the ability of tumours to evolve components that are, or become, resistant to treatment. My laboratory uses advanced molecular imaging, targeted biopsies, animal models and genetic analysis to detect and understand the basis of such resistance and thereby develop new, targeted treatments to improve patient outcomes.
Integration Of Basic And Translational Genitourinary Cancer Research Into Academic Clinical Practice
Funder
National Health and Medical Research Council
Funding Amount
$467,961.00
Summary
Improvements in human health can only occur when the best basic research is tested in the best clinical trials and then applied in clinical practice across the board. Practitioner Fellowships are designed to support people who bridge these areas. This Fellowship will support an integrated program of research involving laboratory studies in prostate cancer, clinical trials in prostate and other types of cancer, application to clinical practice, and high level clinical and research leadership.
Major advances in cancer treatment has been made by identifying gene mutations in cancers to which the cancer is “addicted”, such that turning off the effects of the mutations leads to death of the cancer cells. Grant McArthur has been successful in applying this principle to rare types of sarcoma bringing his work to routine clinical practice globally. In this application he will investigate targeting the BRAF, KIT and MYC genes focusing on melanoma, a major cancer problem in Australia.
Translating Disordered Iron Metabolism And Liver Injury Research Into Clinical Practice
Funder
National Health and Medical Research Council
Funding Amount
$444,014.00
Summary
Disorders of iron excess or insufficiency are common. A major complication of iron overload is liver disease. Another major cause of liver disease is nonalcoholic fatty liver disease. Most causes of liver disease injure the liver by similar mechanisms. This project will discover new mechanisms by which iron may cause cancer, arthritis, liver and cardiac disease and will define new diagnostic tests and treatments for disorders of iron metabolism and liver disease.