Assessing The Impact Of Geographical Location And Socioeconomics On Clinical Outcomes From Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$317,485.00
Summary
Inequalities in survival from and treatment for breast cancer continue to exist in Australia, particularly for women from rural and remote areas, and for disadvantaged populations. Currently, we do not know to what extent these inequalities are due to individual characteristics or to the area in which a women lives. By understanding how these factors impact on clinical outcomes, we enable us to better target health programs, policy and practice to reduce the burden of cancer.
Large-scale Data To Understand Person-centred Outcomes In Cancer Survivors
Funder
National Health and Medical Research Council
Funding Amount
$1,163,471.00
Summary
Although the majority of people with cancer in Australia now survive long-term, little is known about long-term “person-centred outcomes” for cancer survivors - including mental health, disability, pain and quality of life. This project will use data from >70,000 cancer survivors and >190,000 people without cancer from the general population to generate new knowledge on person-centred outcomes, for different cancer types and over time, to inform and improve health and healthcare.
The Benefits And Harms Associated With Breast Cancer Screening In The Australian Context.
Funder
National Health and Medical Research Council
Funding Amount
$80,222.00
Summary
Australia is caught in a dilemma. Breast screening is well-established however there has been fierce debate about the value of screening programmes. I will determine the frequency of benefit and harm due to breast screening programs in Australia to better understand the true extent of overdiagnosis and overtreatment. Based on this information, I will make recommendations about how breast screening should be provided in Australia in future and clearly communicate this information to the community
My research aims to (1) find ways to minimise the impact of pancreatic cancer through improved prevention, diagnosis and management; (2) contribute to the vigorous international debate about the benefits of vitamin D and the best way to balance the harms and benefits of sun exposure.
Collaborative Australian Renal Cell Carcinoma Epidemiology Study (CARES)
Funder
National Health and Medical Research Council
Funding Amount
$1,677,048.00
Summary
The objective of this project is to increase our knowledge of the causes of renal cell carcinoma, a relatively common, yet understudied, cancer and use this new knowledge to develop a risk prediction tool to provide a rational basis for risk counselling. The proposed project will establish a biobank and generate a research platform that, beyond the duration of the project, will allow us to identify diagnostic and prognostic biomarkers, and therapeutic targets.
A Prospective Study Of The Effects Of Early Life Growth On Adult Mammographic Density
Funder
National Health and Medical Research Council
Funding Amount
$460,517.00
Summary
It is now well-known that a woman's breast density, as measured by a breast scan, is a predictor of her future risk of breast cancer. It is also known that women who are heavier as babies and grow rapidly before age 7 are more likely to develop breast cancer in adult life. The effects were strongest in women who had early puberty. It has been suggested that there are critical points in early life growth that contribute to higher breast density in middle-age. Population-based surveys with early l ....It is now well-known that a woman's breast density, as measured by a breast scan, is a predictor of her future risk of breast cancer. It is also known that women who are heavier as babies and grow rapidly before age 7 are more likely to develop breast cancer in adult life. The effects were strongest in women who had early puberty. It has been suggested that there are critical points in early life growth that contribute to higher breast density in middle-age. Population-based surveys with early life growth data on large numbers of women that span birth to adulthood are necessary to estimate accurately the association between early life growth and breast density in middle age. Few such studies exist; Tasmanian Asthma Study is one of them. In 1968, all 4,194 female Tasmanian school children born in 1961 were surveyed and height and weight measured. Subsequently, weight and height measurements were carried out on samples of this cohort. We are currently conducting the 37-year follow-up of the TAS and to date have traced 87% and achieved a response rate of 77% (2,850) for a postal survey. This included self-reported weight and height measurements and detailed information reproductive history and the use of hormones. Weight, height and waist to hip ratio are currently measured on 600 of these respondents. We have access to school medical records of the full cohort, which have weight and height data measured at school medical inspections throughout school years, and maternal records so far for half of the total cohort, which have information on birth weight and length, and period of gestation. Hence, TAS now provides an ideal opportunity, unique within Australia, to investigate prospectively the association between early life growth and mammographic density in middle-age women. We will measure breast density in these women now they are in their late 40s, using the Australian Mammographic Density Research Facility at The University of Melbourne.Read moreRead less
REDucing Delays In Aneurysmal Subarachnoid Haemorrhage: The REDDISH Study
Funder
National Health and Medical Research Council
Funding Amount
$436,022.00
Summary
Aneurysmal subarachnoid haemorrhage (aSAH) is a rare form of stroke that kills at least 30% of sufferers within 1 month. Outcome can be improved through quickly receiving medical care but many people do not and this likely contributes to the poor outcomes. The REDucing Delays In Subarachnoid Haemorrhage (REDDISH) study will look at cases of aSAH across Tasmanian and Victoria so that we can understand the factors that contribute to delays in treatment and ultimately improve outcomes.
Outcomes After Serious Injury: What Is The Recovery Trajectory And How Do The Priorities For Treatment And Disability Services Change Over Time?
Funder
National Health and Medical Research Council
Funding Amount
$766,630.00
Summary
Traumatic injury is a significant contributor to global disease burden, with serious injury commonly resulting in disability and profound costs to the individual, family and society. This population-based project will describe the long term consequences of injury and recovery experiences of more than 2500 seriously injured patients. This longitudinal study will use quantitative and qualitative data to provide a comprehensive overview of patient outcomes and experiences in the first 5-years after ....Traumatic injury is a significant contributor to global disease burden, with serious injury commonly resulting in disability and profound costs to the individual, family and society. This population-based project will describe the long term consequences of injury and recovery experiences of more than 2500 seriously injured patients. This longitudinal study will use quantitative and qualitative data to provide a comprehensive overview of patient outcomes and experiences in the first 5-years after injury.Read moreRead less