Clinical Trial Of DZ13 DNAzyme Targeting C-Jun In Subjects With Basal Cell Carcinoma - DISCovery (Oligonucleotide Inhibition Of Skin Cancer) Study
Funder
National Health and Medical Research Council
Funding Amount
$74,365.00
Summary
Basal cell carcinoma (BCC) is the commonest skin cancer in Australia that is highly invasive. Surgical removal is its main treatment option but causes scarring and is impractical when there are multiple cancers. C-Jun, a molecule promoting cell growth is present in abnormally large amount in BCC compared to normal cells. Dz13 targets and destroys these molecules, killing cancer cells when injected into the tumour. Dz13 may hence become a more effective and aesthetic alternative of treating BCC.
Predictors Of Psychological Distress In Adult Cancer Survivors:Development Of A Model For Tailoring Health Interventions
Funder
National Health and Medical Research Council
Funding Amount
$99,447.00
Summary
The number of people completing curative cancer treatment is increasing. Many cancer survivors report ongoing concerns with physical, psychological and social consequences of treatment. Little is known about how psychological distress differs between survivors. This research aims to develop an evidence-based model for tailoring interventions to different levels of distress and encouraging adoption of recommended health behaviours to improve survivor outcomes.
Examining The Role Of HIF-1a And Snail-2 In Radiosensitivity Of Oropharyngeal Squamous Cell Carcinoma
Funder
National Health and Medical Research Council
Funding Amount
$78,492.00
Summary
Human papillomavirus (HPV)-induced oropharyngeal squamous cell carcinoma has a significantly better prognosis than that caused by tobacco and/or alcohol. The favorable prognosis is due to a better response to treatment with radiation therapy and chemotherapy but the exact mechanisms are still not clear. This project will investigate these mechanisims at the molecular level and ultimately it will lead us to the development of strategies to improve the response of both HPV and non-HPV induced orop ....Human papillomavirus (HPV)-induced oropharyngeal squamous cell carcinoma has a significantly better prognosis than that caused by tobacco and/or alcohol. The favorable prognosis is due to a better response to treatment with radiation therapy and chemotherapy but the exact mechanisms are still not clear. This project will investigate these mechanisims at the molecular level and ultimately it will lead us to the development of strategies to improve the response of both HPV and non-HPV induced oropharyngeal cancer to radiation therapy.Read moreRead less
A Study To Evaluate Safety And Feasibility Of Administrating Zoledronic Acid To Children And Adolescents With Acute Lymphoblastic Leukemia And Lymphoma To Prevent Joint Complication.
Funder
National Health and Medical Research Council
Funding Amount
$16,231.00
Summary
Osteonecrosis (bone death) is a debilitating complication seen following chemotherapy for acute lymphoblastic leukemia in older children. It potentially could lead to destruction of joint, severely limiting quality of life and ultimately requiring joint replacement surgery. Currently there is no effective medical treatment to manage this. Based on our animal experiments we want to study if Zoledronic acid could prevent severe joint destruction in these children and improve their quality of life.
Quality Of Life And Arm Symptoms Following Axillary Surgery For Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$32,003.00
Summary
The aim of this project is determine how best to measure, analyse and compare the effects of different operations for women with breast cancer. This will be done with information on measurements of arm swelling, symptoms, functions, and other aspects of quality of life collected in over 1,000 women taking part in a national randomised trial. This research will provide important information about the effects of these operations, and about how best to design future surgical trials.
Population-based Genetic Screening For Klinefelters Syndrome: A Critical Analysis
Funder
National Health and Medical Research Council
Funding Amount
$75,468.00
Summary
Klinefelter’s Syndrome (KS) is a common and important genetic condition affecting males, yet 70% are never diagnosed. Males with KS are always infertile and may have hormone imbalances, breast development, decreased facial and pubic hair, and varying levels of cognitive, social, behavioural and learning difficulties. Treatment and intervention options are available, if KS is diagnosed early enough. Screening for the condition is possible - but what would the advantages and disadvantages of this ....Klinefelter’s Syndrome (KS) is a common and important genetic condition affecting males, yet 70% are never diagnosed. Males with KS are always infertile and may have hormone imbalances, breast development, decreased facial and pubic hair, and varying levels of cognitive, social, behavioural and learning difficulties. Treatment and intervention options are available, if KS is diagnosed early enough. Screening for the condition is possible - but what would the advantages and disadvantages of this be?Read moreRead less