Integration Of Epidemiological, Biological, And Health Services Data In Cancer Research
Funder
National Health and Medical Research Council
Funding Amount
$290,032.00
Summary
Improved understanding of carcinogenic mechanisms, such as the importance of gene and environment interaction, has placed increased emphasis on the need for studies combining biological and epidemiological data. The proposed research program incorporates a number of cross-disciplinary studies which bridge classical epidemiology and basic science and strive to improve the clinical relevance and translational potential of research outcomes.
The Role Of Aspirin In The Prevention Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$1,725,799.00
Summary
ASPREE is a large, phase 3 clinical study of health participants over the age of 70 years who have been randomized to either continuous low dose aspirin or placebo for an average of 5 years. This grant is concerned with collecting long-term follow-up for an additional 5 years, especially for evidence of colorectal cancer (CRC) as well as the exploration of potential mechanisms of action by which aspirin may prevent the development of CRC.
Effectiveness And Cost-effectiveness Of Systematic Screening For Lynch Syndrome (LS) In Australia
Funder
National Health and Medical Research Council
Funding Amount
$485,762.00
Summary
Lynch syndrome (LS) is an inherited condition that puts people at an increased risk of developing a range of cancers. We will use a detailed simulation model to evaluate the potential health benefits of testing new cases of colorectal, endometrial and ovarian cancers for LS, and whether this would be cost-effective. The aim is to identify LS-related cancer cases, so family members can be offered LS testing, and individuals found to have LS can be offered close observation/preventative surgery.
The Relationship Between Environmental Exposures And The Development Of Acute Lymphoblastic Leukaemia In Children
Funder
National Health and Medical Research Council
Funding Amount
$88,141.00
Summary
Leukaemia is the most common childhood cancer and is potentially preventable. Little is known about the causes, although it is likely that both genetic and environmental factors play a role. The early age at diagnosis suggests that exposures before birth or in early childhood, may be involved in its development. This study will investigate whether non-occupational environmental exposures in these key time periods increase the risk of disease and thus may help to prevent the disease.
Practice- And Policy-relevant Research In Skin Cancer Epidemiology, Prevention And Screening
Funder
National Health and Medical Research Council
Funding Amount
$483,402.00
Summary
This Fellowship will enable me to lead an internationally-competitive program of research in skin cancer epidemiology, prevention & screening that will lead to improved patient and population health through impacts on clinical practice and health policy. My aim is to lead paradigm-shifting contributions in: ? Genetic epidemiology of melanoma, ? Precision skin cancer prevention & screening, and ? Public health genomics for cancer prevention.
Modelling The Possible Effects Of Low-dose Irradiation In Young Australians Exposed To CT Scans
Funder
National Health and Medical Research Council
Funding Amount
$130,877.00
Summary
Radiation from CT (computerised tomographic X-ray) scans of children may cause a later increase in cancer risk. However, any risk for an individual will be small, so we are using de-identified records to study the average risk of cancer in 600,000 young Australians exposed to CT scans between 1985-2005. Our project has the capacity to detect an increase of 10% in the risk of exposed compared with non-exposed. Results will be available by Dec 2012.
Investigating The Use Of Metformin For The Prevention Of Endometrial Cancer
Funder
National Health and Medical Research Council
Funding Amount
$676,755.00
Summary
Endometrial (uterine) cancer affects approximately 3% of women. Obesity and oestrogen exposure are risk factors for this cancer. A novel approach to prevent endometrial cancer would be to oppose the effects of insulin and oestrogen on endometrial cell growth. This study will investigate whether metformin, commonly used to treat diabetes, blocks cellular pathways by which oestrogen and insulin stimulate endometrial cell growth, and thus evaluate the possibility that metformin might be useful in p ....Endometrial (uterine) cancer affects approximately 3% of women. Obesity and oestrogen exposure are risk factors for this cancer. A novel approach to prevent endometrial cancer would be to oppose the effects of insulin and oestrogen on endometrial cell growth. This study will investigate whether metformin, commonly used to treat diabetes, blocks cellular pathways by which oestrogen and insulin stimulate endometrial cell growth, and thus evaluate the possibility that metformin might be useful in preventing endometrial cancer.Read moreRead less
Breast And Ovarian Cancer: Beyond Genome Wide Association Studies
Funder
National Health and Medical Research Council
Funding Amount
$863,910.00
Summary
My research is focused on using genetic approaches to understand the basis of cancer, particularly breast and ovarian cancer. Although many risk factors have been identified for these cancers, they do not lend themselves to primary prevention, except for high risk individuals who opt for prophylactic surgery, and so there is an urgent need to understand the aetiology of these cancers in order to develop better risk prediction algorithms and risk reduction medications.
The Prevalence, Incidence And Natural History Of Anal Cellular Abnormalities In Mature-aged Homosexual Men
Funder
National Health and Medical Research Council
Funding Amount
$144,725.00
Summary
Anal cancer is one of the most common cancers in homosexual men and rates in Australia are now higher than those of cervical cancer prior to the introduction of routine cervical screening in women. The Mature Aged Gay MenÍs Anal Health Study will enrol 1000 men over 45 years old and follow them for up to 5 years to investigate the progression of anal pre-cancerous lesions in men and the potential of a screening program to allow early detection of these lesions.