Gene Expression Profiling and de novo Transcriptome Sequencing using Geneballs. The purpose of the project is to demonstrate that bead-based technology can be used in applications that currently require DNA hybridisation in order to overcome existing deficiencies in microarray technology. By providing the capability to quickly and efficiently produce, screen and utilize biomolecule libraries of nearly unlimited size, this technology provides the key to unlock the power of genomics and proteomics ....Gene Expression Profiling and de novo Transcriptome Sequencing using Geneballs. The purpose of the project is to demonstrate that bead-based technology can be used in applications that currently require DNA hybridisation in order to overcome existing deficiencies in microarray technology. By providing the capability to quickly and efficiently produce, screen and utilize biomolecule libraries of nearly unlimited size, this technology provides the key to unlock the power of genomics and proteomics for use in real world applications. The project has two aspects. First, relatively small directed cDNA-bead libraries will be compared to known low-density cDNA microarrays to validate the technique for utility in gene expression profiling. Secondly, large libraries containing short oligonucleotide sequences will be used for de novo sequencing of a complete transcriptome. Proof-of-concept in either case will pave the way for many genomic applications and catapult the technology to 'blockbuster' status.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453920
Funder
Australian Research Council
Funding Amount
$108,680.00
Summary
Molecular diagnostics based on real-time polymerase chain reactions for emerging tropical infectious diseases aimed at protecting Australia from invasive diseases. The project aims to use the technique of real-time polymerase chain reaction to rapidly detect and quantify the organisms associated with emerging and re-emerging infectious diseases of man and animals. It will also be used to determine related gene expression.
The equipment will be used to support a wide range of projects that req ....Molecular diagnostics based on real-time polymerase chain reactions for emerging tropical infectious diseases aimed at protecting Australia from invasive diseases. The project aims to use the technique of real-time polymerase chain reaction to rapidly detect and quantify the organisms associated with emerging and re-emerging infectious diseases of man and animals. It will also be used to determine related gene expression.
The equipment will be used to support a wide range of projects that require the detection of specific RNA or DNA and it will allow the rapid, cost effective and efficient processing of either RNA or DNA from large numbers of samples. Minor variations in organisms will be detected using this equipment.
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Hybrid Imaging System for Breast Cancer Detection. Due to the ever increasing number of breast cancer mortalities in Australia, there is an urgent need for an efficient and reliable diagnostic imaging system. This research utilises a novel method to build an imaging system, which is accurate and reliable in the early detection of tumours. The work of this fellowship will improve quality of life of Australian women and put us at the international forefront of research in medical imaging, enhancin ....Hybrid Imaging System for Breast Cancer Detection. Due to the ever increasing number of breast cancer mortalities in Australia, there is an urgent need for an efficient and reliable diagnostic imaging system. This research utilises a novel method to build an imaging system, which is accurate and reliable in the early detection of tumours. The work of this fellowship will improve quality of life of Australian women and put us at the international forefront of research in medical imaging, enhancing our already significant international presence in the area. The project will potentially lead to valuable intellectual property for commercialisation opportunities besides strengthening key international collaborations.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100098
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Advanced facility for next generation sustainable energy, biomedical & nano-imaging optical fibre technologies. Remote optical fibre technologies are the way forward for effective and safe monitoring of many industries, and will play a big part in the sustainability of Australia's core oil, gas and alternative energy sectors. They are equally important to health industry applications, particularly in medical and imaging technologies. This facility brings together world-class Australian expertise ....Advanced facility for next generation sustainable energy, biomedical & nano-imaging optical fibre technologies. Remote optical fibre technologies are the way forward for effective and safe monitoring of many industries, and will play a big part in the sustainability of Australia's core oil, gas and alternative energy sectors. They are equally important to health industry applications, particularly in medical and imaging technologies. This facility brings together world-class Australian expertise—from across nine universities—in advanced structured optical fibres, complex fibre diagnostic systems, nanoscale imaging, and environment monitoring, to design and implement the next generation of technologies that will reduce the impact of climate change through reduced energy consumption and vastly improved health diagnostics.Read moreRead less
Raman spectroscopy and imaging of natural and synthetic melanins. The national benefit of this research lies in three main areas. First, this research could lead to a non-invasive diagnostic for melanoma. Second, it could reveal stronger connections between melanin and melanoma development than previously believed and thus inspire possible methods of treatment or prevention of melanoma. Given Australia's high incidence of melanoma, these could have an enormous impact on our health care system. T ....Raman spectroscopy and imaging of natural and synthetic melanins. The national benefit of this research lies in three main areas. First, this research could lead to a non-invasive diagnostic for melanoma. Second, it could reveal stronger connections between melanin and melanoma development than previously believed and thus inspire possible methods of treatment or prevention of melanoma. Given Australia's high incidence of melanoma, these could have an enormous impact on our health care system. Third, it will increase our understanding of the melanin pigment and further establish Australia as a leader in this field. Given the links between melanin and Parkinson's Disease and immune response, this understanding could have greater impact on health care than simply melanoma.Read moreRead less
Intelligent Image Processing Techniques for Novel Biomarker Discovery. This project will make an impact on Australia's international research profile by seeking a solution to a worldwide challenging problem in biomarker discovery for the detection of diseases at an early stage which requires the incorporation of the skills and knowledge from biology, medicine, engineering, computer science, and information technology. The successful outcomes of this research will make an impact on Australia's e ....Intelligent Image Processing Techniques for Novel Biomarker Discovery. This project will make an impact on Australia's international research profile by seeking a solution to a worldwide challenging problem in biomarker discovery for the detection of diseases at an early stage which requires the incorporation of the skills and knowledge from biology, medicine, engineering, computer science, and information technology. The successful outcomes of this research will make an impact on Australia's engagement in using advanced image analysis and intelligent methods for the emerging research and development of targeted drug discovery. Read moreRead less
On-line and Incremental EM-based Neural Networks: Application to Hospital Utlilization and Gene Expression Data. Artificial neural networks have been widely applied as universal classifiers in many fields, such as biomedicine. However, misunderstanding of fundamental statistical principles, which can cause misleading findings, has been frequently observed in the literature. This project aims to integrate statistical methodologies in neural networks to provide a unified approach to improve its ....On-line and Incremental EM-based Neural Networks: Application to Hospital Utlilization and Gene Expression Data. Artificial neural networks have been widely applied as universal classifiers in many fields, such as biomedicine. However, misunderstanding of fundamental statistical principles, which can cause misleading findings, has been frequently observed in the literature. This project aims to integrate statistical methodologies in neural networks to provide a unified approach to improve its applicability and efficiency in implementation. The system developed from this proposed cross-disciplinary research will be applied to hospital utilization data (hospital morbidity database, Western Australia) and gene expression data (DNA microarrays databases, Harvard University). This collaborative research will advance the international standard of Australian research communities.
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