Investigating Signalling Pathways That Mediate Suppression Of Anoikis By Chemokine Receptors In Metastatic Breast Cancer Cells
Funder
National Health and Medical Research Council
Funding Amount
$597,349.00
Summary
This research aims at understanding the "nuts and bolts" of the main killer in cancer patients - tumour metastasis. We will look for molecules that are specific to metastatic tumour cells that transmit signals from the cell surface to the cell "suicide" machinery and prevent metastatic cancer cell death.
Indwelling Pleural Catheter For Management Of Cancer-related Pleural Effusions
Funder
National Health and Medical Research Council
Funding Amount
$123,688.00
Summary
Most cancers can be complicated by fluid accumulation (effusion) in the (pleural) cavity between the lung and chest wall, causing significant breathlessness. Indwelling pleural catheter (IPC) is a new method that allows patients to drain the effusion outside the hospital and avoid further invasive interventions. This study aims to provide important information that will help guide use of IPC and manage its complications, especially infection, improve patient outcomes and save healthcare costs.
A Targeted Drug Delivery System For Treatment Of Bone Metastasis
Funder
National Health and Medical Research Council
Funding Amount
$243,607.00
Summary
The most common site where cancer spreads is the bone. Once it happens, it can dramatically affect patient’s quality of life and chance of survival. Current treatments are mostly palliative or associate with acute side effects due to systematic administration of anticancer drugs and their inability to selectively target the diseased area. This study aims to develop a nanocarrier that can uptake, protect and deliver anticancer drugs to the affected site in bone.
Which Modifiable Risk Factors Actually Cause Cancer?
Funder
National Health and Medical Research Council
Funding Amount
$384,076.00
Summary
Observational studies suggest that modifiable risk factors such as low vitamin D levels, coffee consumption, alcohol consumption and obesity may be important in cancer risk. However, observational studies can only demonstrate association between a risk factor and cancer, and association does not equal causation. We present an alternative approach to help determine which risk factors actually cause cancer.
Realising The World Health Organisation Targets For Elimination Of Cervical Cancer As A Public Health Problem: Effective Implementation And Scale-up Of HPV Vaccination And Cervical Screening In Australia, Regionally, And Globally
Funder
National Health and Medical Research Council
Funding Amount
$2,125,000.00
Summary
This fellowship focuses on improving cancer screening, particularly the implementation of HPV vaccination and cervical screening. CI Canfell will pursue an Australian, regional and global health agenda towards the elimination of cervical cancer. Her work is supporting the successful implementation of the new cervical screening program in Australia, provides crucial support to other countries in the region, and is directly informing the WHO global elimination strategy.
Cancer Epidemiology In High-risk Populations And Complex Cancers
Funder
National Health and Medical Research Council
Funding Amount
$451,716.00
Summary
My research program aims to better understand the causes of cancer and factors that influence outcomes after cancer diagnosis. It employs classical and innovative cancer epidemiology and includes large-scale studies of cancer incidence, survival and risk factors in people with immune dysfunction. It also includes studies of lymphoid malignancies and ‘cancer of unknown primary’ origin. The research program aims to build an evidence base for interventions that will reduce the burden of cancer nati ....My research program aims to better understand the causes of cancer and factors that influence outcomes after cancer diagnosis. It employs classical and innovative cancer epidemiology and includes large-scale studies of cancer incidence, survival and risk factors in people with immune dysfunction. It also includes studies of lymphoid malignancies and ‘cancer of unknown primary’ origin. The research program aims to build an evidence base for interventions that will reduce the burden of cancer nationally and internationally.Read moreRead less
Characterization Of Ras-Stimulated Macropinocytosis In Pancreatic Cancer
Funder
National Health and Medical Research Council
Funding Amount
$470,964.00
Summary
Pancreatic cancer (PC) is one of the most lethal human cancers, namely due to frequent late stage diagnosis. Thus, there is urgent need to better understand the biology of this disease. Cancer cells are characteristically more reliant on nutrients in order to sustain their growth, making them more vulnerable to inhibition of nutrient supplies. The key aim of this project is to better understand the ways in which PC cells take up nutrients so that these processes may potentially be blocked.
Improving Sexual Health In Men With Prostate Cancer: Randomised Controlled Trial Of Exercise And Psychosexual Therapies
Funder
National Health and Medical Research Council
Funding Amount
$583,416.00
Summary
Sexual dysfunction is one of the most common and distressing side effects of prostate cancer. Despite being a critical survivorship care issue, there is a clear gap in knowledge surrounding the optimal treatment of sexual dysfunction in men with prostate cancer. This project examines whether exercise aids in the management of sexual dysfunction and explores if an integrated treatment model incorporating pharmacological, exercise and psychosexual therapies maximises improvement in sexual health.
Assessment Of The Effects Of Pathogenic Germline TP53 Mutations; International Sarcoma Kindred Study Participants’ Views Of Feedback Of Genetic Research Results And The Acceptability Of Taking Part In A Pilot Screening Programme
Funder
National Health and Medical Research Council
Funding Amount
$55,242.00
Summary
The International Sarcoma Kindred Study (ISKS) aims to identify individuals who harbour germline TP53 mutations. TP53 mutations are characterised by the development of multiple cancers including sarcoma. This project will assess ISKS participants’ views of the feedback of genetic research information and will develop sensitive feedback practices. The acceptability and psychological impact of taking part in a pilot screening protocol designed for cancer-prone populations will also be assessed.
Generating The Evidence To Control Cancer And Optimise Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$6,564,341.00
Summary
Our Program addresses the public health aspects of common cancers, particularly cancers of the skin and gynaecological tracts. Each year in Australia, nearly 400,000 people are treated for skin cancer, and more than 3,500 women develop ovarian or uterine cancer. Our aims are first, to understand how we might prevent these cancers in the future; second, to enhance diagnosis of these cancers; and third, to improve the survival and quality of life for people who are diagnosed with these cancers