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Cognition In First Episode Psychosis: Mapping Relationships Between Task Performance, Brain Changes And Symptoms
Funder
National Health and Medical Research Council
Funding Amount
$79,734.00
Summary
Schizophrenia is a devastating illness. Medication can successfully treat the 'positive' symptoms, such as hallucinations and delusions. However, cognitive impairments have been identified as a greater burden. This project aims to better understand the brain basis of these cognitive impairments, by looking at the relationships between participants’ responses to cognitive tests, their brain activity during the testing, and their symptoms and general functioning over time.
BDNF Genotype And Emotional Memory In Post-traumatic Stress Disorder
Funder
National Health and Medical Research Council
Funding Amount
$108,902.00
Summary
This project addresses the question of why some people develop PTSD following trauma and others don’t. It will assess the influence of genetics (specifically a genotype that influences Brain Derived Neurotrophic Factor) on emotional memory processes as distressing emotional memories are a core symptom of PTSD. If we find that people with a particular genetic profile have a greater risk of developing intrusive memories after trauma, this will help us better target treatment for those individuals.
Exploring The Meaning And Experience Of Cardiovascular Health Of People Who Live With Severe And Persistent Mental Illness.
Funder
National Health and Medical Research Council
Funding Amount
$89,114.00
Summary
People with serious mental illness die up to 25 years before their peers, mostly from cardiovascular disease. Despite extensive research, we have made little impact on addressing this health inequity. By exploring the experience and meaning of personal cardiovascular health to people with severe mental illness, this study aims to generate new knowledge that will inform the tailoring of cardiovascular health promotion interventions that meet the unique requirements of this vulnerable population.
Big Data To Inform The Impact Of Antibiotics And Proton Pump Inhibitors On Immunotherapies Used To Treat Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$115,883.00
Summary
Antibiotics and proton pump inhibitors (PPIs) affect gut bacteria health. Gut bacteria are involved in the function of the immune system and potentially the effectiveness of immunotherapies. However, the impact of antibiotics and PPIs on the efficacy of immunotherapies is unknown. Newly available big data will be used to determine the impacts of antibiotics and PPIs on immunotherapy efficacy, informing on the best cancer treatments to use in patients who require antibiotics or PPIs.
This project aims to comprehensively evaluate the role of androgen receptor (AR) signalling in breast cancer by identifying changes in AR signalling and its role in an endocrine resistant setting. Understanding the changes in AR signalling in either treatment-naive or treatment-resistant context would better assist in the identification for opportunities to modulate AR signalling as a therapeutic target in breast cancer.
Indwelling Pleural Catheter For Management Of Cancer-related Pleural Effusions
Funder
National Health and Medical Research Council
Funding Amount
$123,688.00
Summary
Most cancers can be complicated by fluid accumulation (effusion) in the (pleural) cavity between the lung and chest wall, causing significant breathlessness. Indwelling pleural catheter (IPC) is a new method that allows patients to drain the effusion outside the hospital and avoid further invasive interventions. This study aims to provide important information that will help guide use of IPC and manage its complications, especially infection, improve patient outcomes and save healthcare costs.
Understanding The Clinical Significance Of Tumour Genomic Architecture And Host Immune Response In Breast Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$94,732.00
Summary
This study uses sophisticated DNA sequencing technologies to help patients and their doctors better understand and treat breast cancer. It also tries to understand how the cancer DNA may change over time, and if this is important to how the cancer is treated. In addition, it looks for a link between the DNA changes in a tumour and the anti-tumour immune response, which may help identify patients that could benefit from immunotherapy in the future.
CLINICAL CHARACTERIZATION OF GENETICALLY DEFINED GERMLINE SUB-GROUPS OF MELANOMA AND BREAST CANCER PATIENTS.
Funder
National Health and Medical Research Council
Funding Amount
$140,949.00
Summary
In this project I will assess how cancer patients’ genetic makeup influences the nature and outcome of their cancer, especially in terms of how successful treatment is likely to be. We will show how key genetic variants influence cancer behaviour and by combining these genes we will have a better understanding of how to develop more successful treatments.
Assessment Of The Effects Of Pathogenic Germline TP53 Mutations; International Sarcoma Kindred Study Participants’ Views Of Feedback Of Genetic Research Results And The Acceptability Of Taking Part In A Pilot Screening Programme
Funder
National Health and Medical Research Council
Funding Amount
$55,242.00
Summary
The International Sarcoma Kindred Study (ISKS) aims to identify individuals who harbour germline TP53 mutations. TP53 mutations are characterised by the development of multiple cancers including sarcoma. This project will assess ISKS participants’ views of the feedback of genetic research information and will develop sensitive feedback practices. The acceptability and psychological impact of taking part in a pilot screening protocol designed for cancer-prone populations will also be assessed.