Effectiveness And Cost-effectiveness Of Systematic Screening For Lynch Syndrome (LS) In Australia
Funder
National Health and Medical Research Council
Funding Amount
$485,762.00
Summary
Lynch syndrome (LS) is an inherited condition that puts people at an increased risk of developing a range of cancers. We will use a detailed simulation model to evaluate the potential health benefits of testing new cases of colorectal, endometrial and ovarian cancers for LS, and whether this would be cost-effective. The aim is to identify LS-related cancer cases, so family members can be offered LS testing, and individuals found to have LS can be offered close observation/preventative surgery.
Assessment Of The Effects Of Pathogenic Germline TP53 Mutations; International Sarcoma Kindred Study Participants’ Views Of Feedback Of Genetic Research Results And The Acceptability Of Taking Part In A Pilot Screening Programme
Funder
National Health and Medical Research Council
Funding Amount
$55,242.00
Summary
The International Sarcoma Kindred Study (ISKS) aims to identify individuals who harbour germline TP53 mutations. TP53 mutations are characterised by the development of multiple cancers including sarcoma. This project will assess ISKS participants’ views of the feedback of genetic research information and will develop sensitive feedback practices. The acceptability and psychological impact of taking part in a pilot screening protocol designed for cancer-prone populations will also be assessed.
Re-participation In Screening For Colorectal Cancer: Behavioural Outcomes And Predictors.
Funder
National Health and Medical Research Council
Funding Amount
$687,438.00
Summary
Screening for bowel cancer (CRC) is an important public health initiative. It is most effective when undertaken regularly but there is little research on what personal factors relate to ongoing participation in a screening program. This study will determine the factors associated with ongoing participation in CRC screening and will lead to better screening programs and improved health benefits. This study directly addresses the Cancer Australia priority area re improving screening programs.
Green Tea Polyphenols And Cancer Prevention: Use Of Population Controls And Biomarkers To Elicit Causal Pathways
Funder
National Health and Medical Research Council
Funding Amount
$956,189.00
Summary
There is laboratory evidence that chemicals in green tea (poloyphenols) protect against cancer. Epidemiologic studies in humans have generally supported these findings, especially for breast cancer. This project is a crucial stepping stone towards future prospects of a large-scale trial using green tea extract. It will see if the protection extends to leukaemia and bowel cancer, and will identify the genetic makeup of people who are able to benefit the most from green tea polyphenols.
The Australian And New Zealand Diabetes And Cancer Collaboration
Funder
National Health and Medical Research Council
Funding Amount
$412,291.00
Summary
Diabetes, obesity, metabolic syndrome, hypertension and cancer are chronic diseases faced by many Australians. There is some evidence to suggest that those with diabetes or are obese are at an increased risk of cancer. Sufficiently large studies to examine these relationships do not exist in Australia. This project aims to pool Australian and New Zealand longitudinal studies which have information on diabetes and obesity to examine the relationship between diabetes, obesity and cancer.
Reducing The Burden Of Cancer In Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$257,561.00
Summary
Chronic kidney disease (CKD) is an important public health problem in Australia and worldwide. Not only does CKD predisposes to end-stage kidney disease, but more importantly, increases the risk of co-morbidities such as cancer and cardiovascular disease, leading to premature death. As an academic nephrologist with interests in clinical epidemiology, health economics and translation research, this proposed program of work will focus on assessing the critical areas in improving the cancer outcome ....Chronic kidney disease (CKD) is an important public health problem in Australia and worldwide. Not only does CKD predisposes to end-stage kidney disease, but more importantly, increases the risk of co-morbidities such as cancer and cardiovascular disease, leading to premature death. As an academic nephrologist with interests in clinical epidemiology, health economics and translation research, this proposed program of work will focus on assessing the critical areas in improving the cancer outcomes in patients with CKD.Read moreRead less
Effectiveness And Cost-Effectiveness Of HPV Vaccination And HPV-Based Cervical Cancer Screening Strategies In China
Funder
National Health and Medical Research Council
Funding Amount
$420,692.00
Summary
In the absence of preventative initiatives, up to 187,000 women will develop cervical cancer in China every year. However, the disease is preventable using human papillomavirus (HPV) vaccination and primary HPV screening. Building on previous work, we will evaluate the most effective and cost-effective options for cervical cancer prevention, in order to provide an comprehensive evidence base for China’s health decision-makers.
Breast CAncer STratification: Understanding The Determinants Of Risk And Prognosis Of Molecular Subtypes
Funder
National Health and Medical Research Council
Funding Amount
$472,984.00
Summary
Breast cancer is not one disease, but many different types with different causes, treatments and outcomes. The aim of this project is to use genetic, lifestyle/environmental, mammographic breast density, pathologic and clinical data froma very large number of studies from all over the world to develop ways of predicting which women are at risk of particuar types of breast cancer, and if breast cancer develops what the likely outcome will be.
Anal Cancer Examination (ACE) Study - Annual Anal Examinations To Detect Early Anal Cancer In HIV Positive Men Who Have Sex With Men
Funder
National Health and Medical Research Council
Funding Amount
$60,926.00
Summary
Anal cancer is the most frequently occurring (non-AIDS defining) cancer in HIV positive men who have sex with men. There are still no guidelines for how to screen for this cancer. This research aims to determine the feasibility of implementing an annual anal examination to detect early anal cancer in HIV positive men who have sex with men.
Point-of-care HPV-DNA Testing For Cervical Cancer Screening In High-burden, Low-resource Settings
Funder
National Health and Medical Research Council
Funding Amount
$891,184.00
Summary
We will undertake the first field evaluation of a novel, newly-available, easy to use, and highly accurate point-of-care (POC) test for high-risk human papillomavirus (hrHPV) infection that will allow trained health staff to identify women at increased risk of cervical cancer and to provide same-day cervical cryotherapy for pre-cancer lesions identified on clinical examination.