Multivariate Methods for the Analysis of Microarray Gene-Expression Data with Applications to Cancer Diagnostics. The project will benefit the Australian Society as a whole by developing statistical methodology for the analysis of high-throughput data. In particular, it will develop a novel and easily implemented model for the analysis of correlated and structured data that may be of high dimension. It thus has wide applicability to improving the quality and validity of applied research in most ....Multivariate Methods for the Analysis of Microarray Gene-Expression Data with Applications to Cancer Diagnostics. The project will benefit the Australian Society as a whole by developing statistical methodology for the analysis of high-throughput data. In particular, it will develop a novel and easily implemented model for the analysis of correlated and structured data that may be of high dimension. It thus has wide applicability to improving the quality and validity of applied research in most industries in Australia. More specifically, it is to be applied here to the diagnosis and prognosis of ovarian cancer. This cross-disciplinary project will strengthen Australian researchers' capacity and capability of participating in cutting-edge DNA microarray research.
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Spatio-temporal modelling of Ras dependent MAP kinase activation. This project is at the heart of the national research priority 'Frontier Technologies for Building and Transforming Australian Industries'. Using cutting edge methods and techniques of systems biology, coupled with innovative experimental molecular cell biology we will construct and simulate mathematical models of the EGF-regulated MAP kinase pathway. The project will yield new insights into the fundamental mechanisms of cell sign ....Spatio-temporal modelling of Ras dependent MAP kinase activation. This project is at the heart of the national research priority 'Frontier Technologies for Building and Transforming Australian Industries'. Using cutting edge methods and techniques of systems biology, coupled with innovative experimental molecular cell biology we will construct and simulate mathematical models of the EGF-regulated MAP kinase pathway. The project will yield new insights into the fundamental mechanisms of cell signal transduction that drive cell division, differentiation and transformation and may enable the design of new anticancer therapies. Importantly, the modelling and simulation methods developed in the project will have a general applicability to other complex systems such as sustainable ecological systems.Read moreRead less