Exposure To High Dose Estrogens In Adolescence: Long Term Effects On Mammographic Breast Density
Funder
National Health and Medical Research Council
Funding Amount
$89,050.00
Summary
Breast density is a well established risk factor for breast cancer, and has been shown to be reversibly influenced by hormone exposures in adult life. As one of the important roles of sex hormones during puberty is mammary cell proliferation, it is plausible that exposures at this earlier life stage might have a sustained influence on breast tissue composition and density, and subsequent breast cancer risk. This project aims to increase our understanding of the influence of sex hormones in adole ....Breast density is a well established risk factor for breast cancer, and has been shown to be reversibly influenced by hormone exposures in adult life. As one of the important roles of sex hormones during puberty is mammary cell proliferation, it is plausible that exposures at this earlier life stage might have a sustained influence on breast tissue composition and density, and subsequent breast cancer risk. This project aims to increase our understanding of the influence of sex hormones in adolescence on breast cancer risk by testing the hypothesis that exposure to large doses of sex hormones during adolescence has long-term effects on mammographic density. This will be done by comparing the mammographic densities of women who were treated with high doses of estrogen for tall stature during adolescence with women who were similarly assessed for tall stature but not treated. No previous study in humans has examined the long-term effects on breast tissue of high dose estrogen exposure at this early life stage. This is not surprising, given the difficulty in finding a suitable exposed population. This cohort of women, assessed or treated for tall stature, provides us with a unique opportunity to examine these influences. This research will add to our understanding of the influence of sex hormones in adolescence on mammographic density and breast cancer risk. If hormonal factors in adolescence are shown to influence mammographic density, this may lead to new avenues for breast cancer prevention efforts that are targeted much earlier in life. This information may lead to new research directions examining adolescent hormonal exposures (both endogenous and exogenous) and their influence on breast tissue.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101204
Funder
Australian Research Council
Funding Amount
$432,854.00
Summary
Digital citizenship and girls’ gender empowerment. Employing youth participatory action research in Indonesia, this project investigates the digital tools, resources, and strategies used by female youth to advocate for social change. The existing strategies used by development organisations rely on traditional, top-down advocacy approaches, overlooking the innovative ways girls and young women in developing countries use digital technologies to teach one another about gender-based violence and e ....Digital citizenship and girls’ gender empowerment. Employing youth participatory action research in Indonesia, this project investigates the digital tools, resources, and strategies used by female youth to advocate for social change. The existing strategies used by development organisations rely on traditional, top-down advocacy approaches, overlooking the innovative ways girls and young women in developing countries use digital technologies to teach one another about gender-based violence and empowerment. Expected outcomes include youth-centred digital strategies and publicly accessible resources. The project's findings will be used to improve the design of gender empowerment programs that can be scaled up to enhance the Australian government’s aid distribution.Read moreRead less
A longitudinal enquiry into Chinese women graduates' post-study experience. This longitudinal study of female Chinese graduates of Australian universities will be the first to track how international education changes these women’s lives long-term. Through in-depth interviews with graduates in China and Australia, it aims to reveal the lasting benefits of an Australian education for our international graduates, providing significant insights for the recovery of Australian international education ....A longitudinal enquiry into Chinese women graduates' post-study experience. This longitudinal study of female Chinese graduates of Australian universities will be the first to track how international education changes these women’s lives long-term. Through in-depth interviews with graduates in China and Australia, it aims to reveal the lasting benefits of an Australian education for our international graduates, providing significant insights for the recovery of Australian international education in a post-COVID world. Further, the project expects to contribute to scholarly, public and government understandings of new Chinese migrants in Australia, provide new knowledge about cultural change in the middle classes of Asia’s largest and most powerful nation, and enhance Australia’s engagement with its region.Read moreRead less