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Assessment Of Calcium Signaling In Breast Cancer Cells Associated With Epithelial-mesenchymal Transition
Funder
National Health and Medical Research Council
Funding Amount
$116,762.00
Summary
This research will assess the role of specific proteins that control cell function in a process which is important in the spread of cancer cells throughout the body. The work is aimed at identifying new targets for drugs that may be used to prevent or stop the spread of breast cancer cells to other organs such as the brain and liver.
Early Detection Of Coronary Artery Disease: An Opportunity To Start Secondary Prevention Without A Coronary Event
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
Coronary artery disease (CAD) is a major cause of death and disability in Australia, and prevention is key. Our current techniques for predicting who is at high risk of CAD are imperfect or expensive. We aim to study how using the combination of a genetic and metabolic risk score can be used to cost-effectively predict this risk more accurately. By doing so, we aim to develop a new combined test to identify Australians at high risk of CAD so that prevention can be started early.
Parathyroid Hormone-related Protein (PTHrP), Common Genetic Variants In The PTHrP Gene (PTHLH), And Breast Cancer Risk And Survival
Funder
National Health and Medical Research Council
Funding Amount
$120,253.00
Summary
In a partnership between Peter MacCallum Cancer Centre, St Vincent's Hospital, and The University of Melbourne, we are investigating the role of PTHrP, a peptide integral to the growth and spread of Cancer. Initially thought to facilitate cancer spread, recent studies suggest it may actually be protective. In a new approach, we will analyse new DNA databases and patient data from around the world. We hope to extend our understanding of PTHrP, and perhaps find novel drug and therapeutic targets.