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Socio-Economic Objective : Nervous system and disorders
Research Topic : calcium ion imaging
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  • Researchers (12)
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  • Funded Activity

    Discovery Projects - Grant ID: DP1097059

    Funder
    Australian Research Council
    Funding Amount
    $150,000.00
    Summary
    Automatic Brain Tissue Segmentation in Magnetic Resonance Images based on Knowledge-guided Constrained Clustering. Accurate volumetric measurement of brain tissues is of critical importance in the study of many brain disorders, disease diagnosis, disease progression tracking and treatment monitoring. The study in this research will result in the development of a powerful computational technique that allows automatic volumetric measurement and analysis of brain tissues. The software developed in .... Automatic Brain Tissue Segmentation in Magnetic Resonance Images based on Knowledge-guided Constrained Clustering. Accurate volumetric measurement of brain tissues is of critical importance in the study of many brain disorders, disease diagnosis, disease progression tracking and treatment monitoring. The study in this research will result in the development of a powerful computational technique that allows automatic volumetric measurement and analysis of brain tissues. The software developed in this project will expedite early clinical diagnosis and treatment of neural diseases for patients, hence saving life and reducing health cost both at the personal and the national level.
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    Funded Activity

    Linkage Projects - Grant ID: LP0454997

    Funder
    Australian Research Council
    Funding Amount
    $70,668.00
    Summary
    New Imaging Agents for Neuronal Nicotinic Receptors. Recent advances in medical imaging technology such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) have radically improved the diagnosis and treatment of a wide range of diseases. The aim of this project is to discover novel radio-ligands that selectively bind to neuronal nicotinic acetylcholine receptors. These ligands will have great potential for the imaging, diagnosis and study of neurodegenerat .... New Imaging Agents for Neuronal Nicotinic Receptors. Recent advances in medical imaging technology such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) have radically improved the diagnosis and treatment of a wide range of diseases. The aim of this project is to discover novel radio-ligands that selectively bind to neuronal nicotinic acetylcholine receptors. These ligands will have great potential for the imaging, diagnosis and study of neurodegenerative diseases such as Alzheimer's disease.
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    Funded Activity

    Discovery Projects - Grant ID: DP0663987

    Funder
    Australian Research Council
    Funding Amount
    $420,000.00
    Summary
    Development of Novel Two-dimensional Techniques for Magnetic Resonance In-vivo Spectroscopy. Body chemistry alters with functionality, pain, ageing and disease. These changes can be recorded by magnetic resonance (MR) spectroscopy (MRS) in vivo in a whole body MR scanner. When changes in chemistry can be recorded rapidly, and the individual species assigned, it will be possible to make a definitive diagnosis and in some cases allow the tailoring of treatment on an individual basis. This is curre .... Development of Novel Two-dimensional Techniques for Magnetic Resonance In-vivo Spectroscopy. Body chemistry alters with functionality, pain, ageing and disease. These changes can be recorded by magnetic resonance (MR) spectroscopy (MRS) in vivo in a whole body MR scanner. When changes in chemistry can be recorded rapidly, and the individual species assigned, it will be possible to make a definitive diagnosis and in some cases allow the tailoring of treatment on an individual basis. This is currently hampered by our inability to separate the composite resonances in a one dimensional MR spectrum. Research will allow two dimensional MRS to be implemented and provide detailed chemical information on human organs in vivo.
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    Funded Activity

    Discovery Projects - Grant ID: DP0557844

    Funder
    Australian Research Council
    Funding Amount
    $100,000.00
    Summary
    Hemispheric asymmetry of motor and language representation: Effects of hand preference and mirror movements. The neuroscience community has recently exploited advances in brain imaging to understand cerebral representation of many cognitive functions. The proposed study will expand our knowledge of brain-behaviour relationships, another key area of cognitive neuroscience research. Its successful funding and completion will increase Australia's standing as a major contributor to world research ou .... Hemispheric asymmetry of motor and language representation: Effects of hand preference and mirror movements. The neuroscience community has recently exploited advances in brain imaging to understand cerebral representation of many cognitive functions. The proposed study will expand our knowledge of brain-behaviour relationships, another key area of cognitive neuroscience research. Its successful funding and completion will increase Australia's standing as a major contributor to world research outcomes in this innovative and important field, and place Australia at its forefront. The investigator's access to advanced brain imaging and to the unique population of individuals with mirror movements, combined with expertise and experience in neuropsychology and brain imaging, places the research in an internationally competitive position.
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    Funded Activity

    Discovery Projects - Grant ID: DP0774213

    Funder
    Australian Research Council
    Funding Amount
    $285,000.00
    Summary
    Quantifying cortical thickness and white matter hyperintensity volumes and determining their relationship on Magnetic Resonance Imaging in ageing brains. Australia's population is ageing, with a significant projected increase in the number of people aged over 65 and 85. Mental health and quality of life for this ageing population have become an increasingly important issue. This project directly addresses the National Research Priority 2 in the terms of ageing well, ageing productively. Accurat .... Quantifying cortical thickness and white matter hyperintensity volumes and determining their relationship on Magnetic Resonance Imaging in ageing brains. Australia's population is ageing, with a significant projected increase in the number of people aged over 65 and 85. Mental health and quality of life for this ageing population have become an increasingly important issue. This project directly addresses the National Research Priority 2 in the terms of ageing well, ageing productively. Accurately measuring the distribution of brain structural changes is an effective way of differentiating normal ageing from various pathological conditions reflecting the underlying pathology. The project has access to an unprecedented large sample of longitudinal Magnetic Resonance Imaging and health/clinical data and will produce a set of algorithms to examine this issue and put Australia at the forefront of such research.
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    Funded Activity

    Discovery Projects - Grant ID: DP0208483

    Funder
    Australian Research Council
    Funding Amount
    $24,000.00
    Summary
    Using musical training to examine brain plasticity and cognitive skill development. Until recently, the brain was likened to a computer - hard-wired with minimal response to injury. Research is beginning to alter this view, suggesting that the brain can change its structure and functioning in response to the environment. To explore this new and exciting issue, this study will use sophisticated brain scanning techniques with musicians who have been exposed to early training during a critical peri .... Using musical training to examine brain plasticity and cognitive skill development. Until recently, the brain was likened to a computer - hard-wired with minimal response to injury. Research is beginning to alter this view, suggesting that the brain can change its structure and functioning in response to the environment. To explore this new and exciting issue, this study will use sophisticated brain scanning techniques with musicians who have been exposed to early training during a critical period of development. It will examine the relationship between this exposure and changes in brain size and function thought to underlie a specialised ability, known as perfect pitch. The findings will have important implications about the way normal development can be enhanced by early experience and practice.
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    Showing 1-6 of 6 Funded Activites

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