Development Of A Low-cost, Very Low-radiation Community-based Screening Method For Primary Prevention Of Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
Virtually everyone's life has been affected by cardiovascular disease (CVD) in some way. There are no routine community-based tests to identify asymptomatic CVD due to current tests being invasive, expensive, time-consuming or high radiation exposure. A low cost, very low radiation test from existing machines used for osteoporosis screening can assess a measure of asymptomatic CVD. This fellowship seeks to develop this test for community-based screening strategies.
Calcification of the arteries is a ubiquitous finding in patients with end stage renal failure. It is often mirrored by disturbed bone metabolism. Increasing evidence suggests a close relationship between bone and vascular health. This study aims to determine the role of calciprotein particles as a mediator of calcification in bones and arteries. Translating these findings to renal patients will ultimately contribute to providing a scientific basis for developing treatment for these patients.
IMPROVE-CKD Study: Impact Of A Phosphate Binder On Cardiovascular Disease In Chronic Kidney Disease.
Funder
National Health and Medical Research Council
Funding Amount
$1,596,698.00
Summary
Chronic kidney disease (CKD) is a significant health problem and is associated with an increased risk of cardiovascular (CV) disease. Vascular calcification and arterial stiffness (stiffening of the blood vessels and arteries) are very common in people with CKD, and are linked to increased death from CV events. This study aims to examine the ways in which treatment with a phosphate binder, Lanthanum Carbonate, may reduce vascular calcification and arterial stiffness to decrease CV events.