Transcription factor nuclear residency as a driver of gene expression. Persistently active proteins can stay in the nucleus to drive cell growth and prevent cell death. This project will define how one specific active protein can remain in the nucleus and regulate gene expression through the action of unique ribonucleic acid (RNA) molecules. The results will enable persistent gene activation to be manipulated in cancer.
Molecular dynamics of steroid receptor crosstalk. This project uses state-of-the-art technology to show how steroids (for example, testosterone) affect many aspects of human life, and how these can be disrupted by chemicals and synthetic hormones. The results can be used to interpret disease, predict safety of new drugs, and to monitor risk to humans and wildlife of environmental chemicals.