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Host-pathogen Interaction: The Battle For Supremacy
Funder
National Health and Medical Research Council
Funding Amount
$480,014.00
Summary
This grant will provide salary support for Dr Rowena Bull. Dr Bull's research is focused on understanding the disease process between the human host and the infecting virus. The outcomes of this research will be used to find novel ways to fight viral infections with vaccines and drugs.
Monitoring And Improving Hepatitis C Health Outcomes Among People With Hepatitis C
Funder
National Health and Medical Research Council
Funding Amount
$463,652.00
Summary
In Australia, hepatitis C is associated with considerable morbidity and mortality, costing $9.2 billion to the health care system. In the next year, side-effect prone hepatitis C therapies will be replaced with simple, tolerable, interferon-free therapies (cure >90%) that can reverse liver disease progression. My goal is to further develop my established research program in population-health related to HCV epidemiology, and therapeutic strategies, with a specific focus on PWID.
Associations Between Periodontal Disease And Cardiovascular Surrogate Endpoints In An Adult Indigenous Population
Funder
National Health and Medical Research Council
Funding Amount
$413,242.00
Summary
The relationship between periodontal disease and cardiovascular risk markers, both of which are high among the Indigenous Australian population, is established. This study seeks to explore the prevalence of periodontal disease and cardiovascular risk markers among this population, and to determine if implementation of a periodontal intervention leads to improved cardiovascular risk outcomes. There may be benefit in applying this model to other areas of Indigenous health promotion and research.
Investigating Mitochondrial Outer Membrane Permeabilization During Programmed Cell Death
Funder
National Health and Medical Research Council
Funding Amount
$88,065.00
Summary
Cancer cells often contain defects which prevent their death. To kill cancer cells we must either reset or bypass these defects. Release of cytochrome c from mitochondria is a critical event in cell death and proteins that block this event render cells resistant to many cancer therapies. My research will determine how cytochrome c release occurs, how this event is regulated and how to kill cancer cells in which cytochrome c release is blocked.
Optimising Treatment As Prevention Strategies For Hepatitis C And HIV
Funder
National Health and Medical Research Council
Funding Amount
$471,809.00
Summary
New evidence shows how hepatitis C (HCV) and HIV transmission can be reduced dramatically through timely treatment initiation - treatment as prevention (TasP). TasP has re-focused attention on early HCV and HIV detection and treatment. Through observational studies, randomised control trials and the development of innovative surveillance systems, this fellowship will inform ways to maximise the potential of HCV and HIV prevention responses in Australia and internationally in this new TasP era.
Recently Acquired Hepatitis C Infection: Insights From Virological, Therapeutic And Epidemiological Studies
Funder
National Health and Medical Research Council
Funding Amount
$415,218.00
Summary
Every year around 10,000 new cases of hepatitis C (HCV) infection occur within Australia, most of which are undiagnosed. Reasons for this include a lack of public awareness about the benefits of treatment at this stage. As new antiviral agents become available it is likely that therapy for recent HCV will become even easier and more successful. The aim of this research is to explore HCV transmission patterns, treatment strategies and long term health outcomes in people with recent HCV.
Studies On The Pathogenesis And Treatment Outcomes Of Chronic Viral Hepatitis
Funder
National Health and Medical Research Council
Funding Amount
$415,218.00
Summary
The global impact of hepatitis B and hepatitis C has recently been recognized by the World Health Organization. The Fellowship will support a research program that will use new technologies to answer a number of important questions concerning the pathogenesis of viral hepatitis B and C, interferon treatment response for HCV, and antiviral drug resistance. The outcomes of the research will be timely, clinically relevant, and of great interest to the international community. The ultimate goal is t ....The global impact of hepatitis B and hepatitis C has recently been recognized by the World Health Organization. The Fellowship will support a research program that will use new technologies to answer a number of important questions concerning the pathogenesis of viral hepatitis B and C, interferon treatment response for HCV, and antiviral drug resistance. The outcomes of the research will be timely, clinically relevant, and of great interest to the international community. The ultimate goal is to improve clinical outcomes for patients.Read moreRead less
Epidemiology, Natural History And Treatment Of Hepatitis C Virus Infection In Injecting Drug Users
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
In Australia, the majority of hepatitis C is acquired by injecting drug users (IDUs). Given the asymptomatic nature of infection and difficulties in identifying and following those at risk of acquiring infection, our knowledge of hepatitis C has been hampered. The overall goal of this proposed research is to assess markers to better diagnose and predict clearance of hepatitis C, assess hepatitis C transmission and assess health services to enhance HCV assessment and treatment among IDUs.
Dendritic Cells In Innate Immunity And Their Potential Clinical Manipulation
Funder
National Health and Medical Research Council
Funding Amount
$443,946.00
Summary
Dendritic cells (DC) are rare cells that are crucial in response to infection and surveillance of damaged tissues. We aim to understand the tools that are expressed by DC that allow them to sense pathogens and the functions of different DC types once a pathogen has been detected. The ultimate aim is to be able to understand and harness the functions of different DC so that we may directly target them upon demand to aid in the course of infection or potentially as tumour therapy.