Consequences Of Elevated Maternal Glucocorticoids For Early Childhood Renal Development And Function
Funder
National Health and Medical Research Council
Funding Amount
$605,190.00
Summary
A growing body of evidence links maternal stress, such as that precipitated by financial problems or relationship issues (marriage break-up, physical or emotional abuse), with preterm birth and low-birth weight, which in turn has been linked to increased risk of adult disease. Our studies examine how maternal stress impacts on kidney development in childhood and sets the child on the path to cardiovascular disease in adulthood.
A Dual Antigen Synthetic Peptide Subunit Vaccine Approach To Prevent Streptococcal Associated Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$604,017.00
Summary
Infection with streptococcus is responsible for causing more than 500,000 deaths each year, the majority of which are due to rheumatic fever and rheumatic heart disease, which contributes to cardiovascular disease. Our research is aimed at the development of a vaccine to prevent heart disease and involves targeting multiple molecules present on the bacterial surface. We will use a novel vaccine delivery system developed in the laboratory, which will enable the vaccine to be delivered nasally.
Non-invasive Assessment Of Vascular Health In Maternal-fetal And Other Susceptible Populations
Funder
National Health and Medical Research Council
Funding Amount
$402,679.00
Summary
The research in this application focuses on the development and refinement of non-invasive techniques for assessing subclinical atherosclerosis, and cross-disciplinary application of these techniques to identify cardiovascular risk factors and ‘at-risk’ individuals. Emerging and poorly understood risk factors of public health importance are a priority, and include: * Maternal-fetal health * Obesity * Indigenous health
Improving The Prevention, Treatment And Management Of Cardiovascular & Chronic Disease In The Community
Funder
National Health and Medical Research Council
Funding Amount
$774,540.00
Summary
The identification, prevention and management of cardiovascular and chronic disease risk factors and understanding impact on clinical outcomes is fundamental to improving health and well-being. The program of work encapsulated in this application utilises modern epidemiological research methods involving large scale clinical trials, registries and epidemiological modelling to advance our understanding and provide new directions for cardiovascular disease prevention and management.
Improving Functional Outcomes After Fontan Surgery By A Cross-sectional Study Of The Outcomes Following Variation In Practice In Australia And New Zealand: Focus On Anticoagulation And Cardiac Shunting By The Fenestration
Funder
National Health and Medical Research Council
Funding Amount
$768,643.00
Summary
The Fontan procedure is the last of a series of life-saving operations offered to children born with only one pumping chamber in their heart. We intend to perform the largest and most detailed investigation to date of the patients enrolled in the Australia and New Zealand Fontan Registry, today the world's largest database of this kind. This cross-sectional study will enable us to identify the drugs and interventions that will best maximize their exercise capacity and quality of life
National Database Of Patients With Atrioventicular Septal Defects
Funder
National Health and Medical Research Council
Funding Amount
$45,341.00
Summary
Atrioventricular septal defects are a group of childhood heart diseases affecting all four chambers of the heart and two of the valves. These children do not normally survive past 30 years without surgery. Surgery offers a chance at life, but in the long term up to a quarter of children need further surgery. We are developing an Australian database to determine how best to reduce the risk of these complications, the burden on these children and the cost to society.
Guaranteeing Survival Into Adulthood, Physical Health And Psychological Well-being To Children Born With Single Ventricles.
Funder
National Health and Medical Research Council
Funding Amount
$342,773.00
Summary
Being born with a single pumping heart chamber is the most severe heart condition but thanks to several operations we can see them survive. A growing population of young functional adults now face an uncertain future and we have no options for them. A/Pr Y d’Udekem is a leading paediatric cardiac surgeon. His research aims to provide the medications, reinterventions and artificial hearts that are necessary to give them a longer and fulfilling life.