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Cell Therapy For Prevention Of Perinatal Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$539,337.00
Summary
Exposure of babies to infection or inflammation before birth is common and is associated with preterm delivery and illness in newborns. The biggest problem for these babies is lung disease due to inflammation of the lungs before birth and/or in response to lung injury after birth. There is no treatment for the underlying inflammation and no way to prevent or treat the lung disease that it causes. This project will investigate a new stem-cell based treatment for lung inflammation that may prevent ....Exposure of babies to infection or inflammation before birth is common and is associated with preterm delivery and illness in newborns. The biggest problem for these babies is lung disease due to inflammation of the lungs before birth and/or in response to lung injury after birth. There is no treatment for the underlying inflammation and no way to prevent or treat the lung disease that it causes. This project will investigate a new stem-cell based treatment for lung inflammation that may prevent life-threatening lung disease in preterm babies.Read moreRead less
Birth is one of the greatest physiological challenges that we will ever experience and so it is not surprising that it is a period of high risk of death. Despite the risk, our understanding of how infants transition from fetal to newborn life is limited. My research is focused on improving our understanding of how infants make the transition at birth so that we can reduce the risks for these most vulnerable of humans. In particular, I want to improve outcomes for infants born very premature.
Preventing Preterm Lung Disease - A Cell Therapy Approach.
Funder
National Health and Medical Research Council
Funding Amount
$460,610.00
Summary
Due to improvements in medical care, the survival of very premature babies has greatly improved over the past 20 years. However, many of these children are surviving with disability due to severe chronic lung disease of prematurity. Currently, there are no effective treatments for this lung disease. This project explores the use of placental stem cells as a lung repair and regeneration therapy - a therapy that can be given to the baby in the days immediately following its birth.