Adolescent Alcohol And Tobacco Use/abuse: The Efficacy Of A Brief Motivational Interviewing And Skills Training Program
Funder
National Health and Medical Research Council
Funding Amount
$153,610.00
Summary
Alcohol abuse (regular and episodic heavy drinking) and tobacco use are common and increasing amongst young Australians. Around 49% of adolescents are regular drinkers, and 15.5% of females and 33% of males are occasional binge drinkers. Between 17.5% and 35.5% of adolescents smoke and this has increased from 1987. While the majority of young Australians moderate their drinking and smoking over time, about 5% will become heavy drinkers and 20% will become regular smokers. The public health conse ....Alcohol abuse (regular and episodic heavy drinking) and tobacco use are common and increasing amongst young Australians. Around 49% of adolescents are regular drinkers, and 15.5% of females and 33% of males are occasional binge drinkers. Between 17.5% and 35.5% of adolescents smoke and this has increased from 1987. While the majority of young Australians moderate their drinking and smoking over time, about 5% will become heavy drinkers and 20% will become regular smokers. The public health consequences of heavy drinking and smoking are now well documented. There are many studies exploring the effectiveness of universal prevention programs designed to reduce the chance of alcohol and tobacco problems in high school students. These are associated with short term reductions in the chance of smoking and heavy drinking, however it is unclear whether these programs work for adolescents who are at high risk of alcohol problems and sustained smoking. We know a lot about the sorts of risk factors associated with these problems. They include early onset of use, parental involvement and use, particular personality traits, poor marks, peer use, and poor social skills. There is no research that clearly evaluates prevention programs for adolescents who show these risk factors. In this research, a program tailored for high-risk adolescents will be compared to an educational program similar to what is often received in Australian high schools. It is expected that high-risk students will not show changes in the educational program, but will show long-term improvements after completing the enhanced program. If these results hold, the research will have very important implications for detecting high-risk students and modifying the ways in which these adolescents are treated so that we minimise the chance of further development of alcohol and tobacco problems. This could result in large health cost savings in the future.Read moreRead less
An International Randomised Trial Of Low-dose Aspirin To Prevent Recurrent Venous Thromboembolism (INSPIRE)
Funder
National Health and Medical Research Council
Funding Amount
$1,989,986.00
Summary
Patients who develop venous blood clots or pulmonary embolism, without an underyling cause, are at very high risk of recurrence once anticoagulant treatment (warfarin) is discontinued. The international INSPIRE trial is assessing whether low-dose aspirin treatment (a simple and cheap alternative to warfarin) is effective and safe in preventing further blood clots. If proven effective, aspirin could potentially prevent thousands of patients worldwide from experiencing such events.
Low-dose Aspirin To Prevent Recurrent Venous Thromboembolism (ASPIRE) Study: A Multicentre Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,108,600.00
Summary
In approximately one-third of patients who develop deep vein thrombosis or pulmonary embolism, this event is 'unprovoked' . These patients are at very high risk of recurrence once treatment with warfarin is discontinued. Warfarin treatment is very effective to prevent recurrence but is inconvenient because it has to be very closely monitored with blood tests and also causes serious bleeding complications in a significant number of patients. There are currently no other treatments available to pr ....In approximately one-third of patients who develop deep vein thrombosis or pulmonary embolism, this event is 'unprovoked' . These patients are at very high risk of recurrence once treatment with warfarin is discontinued. Warfarin treatment is very effective to prevent recurrence but is inconvenient because it has to be very closely monitored with blood tests and also causes serious bleeding complications in a significant number of patients. There are currently no other treatments available to prevent recurrent thrombosis. Low-dose aspirin treatment offers a simple, inexpensive, and widely practicable alternative to warfarin but has not yet been proven to be effective for preventing recurrent thrombosis. This study will investigate the effectiveness and safety of aspirin to prevent recurrence in patients with unprovoked deep vein thrombosis or pulmonary embolism who have completed standard anticoagulation with heparin and warfarin. If proven to be effective, aspirin could potentially prevent thousands of patients from experiencing recurrent venous thromboembolism or fatal pulmonary embolism worldwide and also save millions of dollars in health care costs each year.Read moreRead less
A New Approach To Curbing Risky Trajectories Of Adolescent Alcohol-tobacco Use: A Tailored Brief Program For Parents.
Funder
National Health and Medical Research Council
Funding Amount
$320,271.00
Summary
Parent-adolescent interactions predict adolescent involvement in alcohol and tobacco use, and parent-oriented programs reduce conduct problems. Nevertheless, parent training is a rare alcohol-tobacco-related prevention strategy. This research will evaluate a brief parent program for adolescents at risk of escalating alcohol-tobacco problems. The technology should be cost-effective and readily complement existing school prevention strategies.
Examining GWAS-identified Loci Of Interest In Predicting Coronary Events In Subjects With Known Coronary Heart Disease: The LIPID Genetic Study
Funder
National Health and Medical Research Council
Funding Amount
$649,940.00
Summary
Can modern genetic analysis identify the genes which predict future heart attacks? We will follow up 4337 patients who have already suffered a heart attack and use the findings from the exciting new technique of GWAS (Gene wide association studies) to study their whole genetic map, select gene markers from thousands of possibilities to identify those at highest risk. This will develop a genetic markers of risk and shed light on previously unsuspected mechanisms of heart disease.
Management Of Coronary Heart Disease In The Indigenous Population In Western Australia: From Information To Action
Funder
National Health and Medical Research Council
Funding Amount
$1,110,455.00
Summary
This study will provide up to date and definitive data on the burden of acute coronary heart disease among Indigenous and non-Indigenous people in WA and patterns of care. It will document the use of lifesaving coronary interventions, participation in cardiac rehabilitation programs and use of appropriate medicines. Indigenous people will have opportunities to describe any barriers they face to access to receiving standard treatment for a heart attack and secondary prevention afterwards.