Studies On The Effects Of Endogenous And Exogenous Opioids In Modulating Exercise-induced Dyspnoea In People With Moderate / Severe Chronic Obstructive Pulmonary Disease (COPD). Two Double-blind Randomised, Placebo Controlled Trials.
Funder
National Health and Medical Research Council
Funding Amount
$197,086.00
Summary
There is evidence that morphine-like chemicals made by the body itself help reduce breathlessness. It is not clear whether this response is because of the effects of these morphine-like chemicals on the brain, in the lung or both. This study will help understand where these chemicals act to reduce breathlessness in people with emphysema during exercise. Subsequently, it will also help to understand whether small, regular doses of morphine safely further reduce breathlessness during exercise.
Management Of Breathlessness. Cognitive Behavioural Therapy For People With Chronic Obstructive Pulmonary Disease (BREVE RCT)
Funder
National Health and Medical Research Council
Funding Amount
$402,875.00
Summary
For people with chronic lung disease, breathlessness is common, distressing and difficult to relieve. Pulmonary rehabilitation programs have been demonstrated to improve exercise capacity and quality of life. This study will determine whether changing the way people think about the sensation of breathlessness while completing pulmonary rehabilitation, further reduces distress/anxiety and health service use and improve exercise capacity, disability related to breathlessness and quality of life.
Invasive Cardiopulmonary Exercise Testing For The Evaluation Of Unexplained And Complex Multifactorial BREATHlessnEss (i-BREATHE)
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
Breathlessness is a common symptom that can be caused by diseases of the heart, lungs or muscles. It is not uncommon that the cause is undiagnosed either because conventional tests do not yield a diagnosis, or because an individual suffers from multiple diseases. This research aims to use invasive cardiopulmonary exercise testing, a highly specialised test which simultaneously measures breathing, heart and muscle function, to improve the diagnosis and treatment of patients with breathlessness.
Cancers can induce fluid build up within the chest cavity leading to breathlessness impairing quality of life. These three studies are focused on improving MPE care. The PLEASE study aims to determine the mechanism of breathlessness and provide predictors for patient selection for fluid drainage. The AMPLE-2 trial will determine the optimal drainage regime to improve patient related outcomes. The FRAME study will evaluate the safety, tolerability and efficacy of a novel therapy in mesothelioma.
Targeted Approaches To Improve Health Outcomes In Severe Respiratory Disease
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Despite receiving optimal treatment, people with severe lung disease experience distressing symptoms, reduced quality of life and wellbeing, and poor health outcomes. This transformational research will investigate new treatment approaches: an integrated palliative care program and Nasal High Flow therapy at home, to identify benefits for people with lung disease. Additionally this research will examine how patients’ attitudes to illness distress and mental health affect wellbeing and health
Multi-centre RDBC Trial Of Oxygen Vs Air For Relief Of Breathlessness In Terminally-ill Patients With Intractable Dyspno
Funder
National Health and Medical Research Council
Funding Amount
$149,701.00
Summary
This study will compare the effects of oxygen and air in the relief of breathlessness in patients at the end of life who do not currently qualify for home oxygen. This landmark study will provide accurate information about any benefits that oxygen offers for breathlessness in this setting. This international multi-site study will ask 226 people to participate using either oxygen or air for 7 days while keeping a diary. We will measure breathlessness, quality of life, anxiety and side effects exp ....This study will compare the effects of oxygen and air in the relief of breathlessness in patients at the end of life who do not currently qualify for home oxygen. This landmark study will provide accurate information about any benefits that oxygen offers for breathlessness in this setting. This international multi-site study will ask 226 people to participate using either oxygen or air for 7 days while keeping a diary. We will measure breathlessness, quality of life, anxiety and side effects experienced.Read moreRead less
Improving The Treatment Of Breathlessness – A Phase III Randomised, Controlled Trial Of Sustained Release Morphine For The Symptomatic Treatment Of Chronic Refractory Breathlessness. A Palliative Care Clinical Studies Collaborative Study
Funder
National Health and Medical Research Council
Funding Amount
$902,732.00
Summary
More than 300000 Australians are chronically short of breath at rest or on minimal exertion despite optimal treatment of the underlying causes of their breathlessness, of whom 70000 cannot leave home. No medication in the world is registered to treat this. There is evidence that regular, low dose morphine safely helps breathlessness. This study will help clinicians adjust doses more effectively and understand whether using an additional medication to reduce anxiety helps relieve breathlessness.
Optimising Outcomes For Chronic Obstructive Pulmonary Disease (COPD): Evaluation Of Walking Training.
Funder
National Health and Medical Research Council
Funding Amount
$440,161.00
Summary
This will be the first study to examine whether a short-term and long-term program of ground walking training is sufficient to improve and maintain exercise capacity and quality of life in people with COPD. If ground walking training is shown to be an effective intervention, this will translate into more widespread provision of exercise training to people with COPD, particularly those living in rural or remote communities.