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Clinicopathological Characterisation Of Male Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$113,322.00
Summary
Male Breast Cancer is an uncommon and poorly understood disease. Due to its low frequency, there is a paucity of studies with large numbers of patients. Our aim will be to establish one of the largest worldwide databases of Male Breast Cancer. This will allow us to more thoroughly investigate clinical, pathological and molecular characteristics of male breast cancer, improve treatment of these patients and potentially develop novel and innovative strategies for treatment of female breast cancer.
Translating Molecular Determinants Of Susceptibility And Progression In Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$6,510,085.00
Summary
Breast cancer is the most common cancer in women. Despite improvements in prevention, detection and treatment, it is the 2nd most common cause of cancer death in Australian women. Research advances in the last decade have improved our understanding of the pathways from susceptibility to progression and metastasis but this has mostly not yet translated into better outcomes. This program aims to translate some of our fundamental discoveries to improve outcome for affected women and their families.
In women there is a strong link between increased risk of breast cancer and low levels of vitamin D. We will use a novel explant system where breast tissue biopsies from women with breast cancer will be used to explore the metabolism of vitamin D and its consequences. This grant proposal will determine the dose of vitamin D that will provide a preventative strategy for breast cancer in the general population, and potential of vitamin D as an adjunct treatment in women with breast cancer.
Cellular And Molecular Aspects Of Mammographic Density As A Predictor Of Breast Cancer Risk In Pseudo-orthotopic Mammatrophic Environment
Funder
National Health and Medical Research Council
Funding Amount
$113,322.00
Summary
High mammographic density (MD), or denser breast tissue on mammogram, is associated with greater breast cancer risk. Despite this, the basis for its increased risk is poorly understood. This study assesses the effect of high density breast tissue transferred from high risk women at time of mastectomy into tissue engineering chambers in mice. Changes in the connective tissue harvested from the chamber were examined with specialized imaging, laboratory stains and molecular analysis.
Centre Of Research Excellence In Precision Public Health Approaches To Breast Cancer Screening, Early Detection And Mortality Reduction
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
The ultimate aim of the CRE is to make it possible to further reduce mortality from breast cancer, and in a more effective way, by identifying women at vastly different levels of risk at younger ages, determining which screening modalities are likely to be more effective, and helping radiologists to better detect cancers. Given that digital mammography is the contemporary standard, and the incidence of breast cancer is increasing across the world, this CRE has global relevance.
Breast Cancer Risk After Diagnostic Gene Sequencing (BRIDGES)
Funder
National Health and Medical Research Council
Funding Amount
$471,281.00
Summary
In BRIDGES, we aim to build a knowledge base to better define individual breast cancer risk. We bring together, in a multidisciplinary team, data and expertise from clinical genetics, epidemiology, bioinformatics, statistics, and gene biology. Specifically, we will use state-of-the art DNA screening to evaluate all suspected breast cancer genes in a large sample of breast cancer cases and controls. We will then use in silico and in vitro functional analyses to evaluate the likely pathogenicity o
Breast And Ovarian Cancer: Beyond Genome Wide Association Studies
Funder
National Health and Medical Research Council
Funding Amount
$863,910.00
Summary
My research is focused on using genetic approaches to understand the basis of cancer, particularly breast and ovarian cancer. Although many risk factors have been identified for these cancers, they do not lend themselves to primary prevention, except for high risk individuals who opt for prophylactic surgery, and so there is an urgent need to understand the aetiology of these cancers in order to develop better risk prediction algorithms and risk reduction medications.
This study focuses on key endocrine pathways involved in the remodelling of the breast stromal cells into a reactive stromal environment which is more permissive for tumour growth. We have identified key pathways involved in the regulation of estrogen biosynthesis and fibrosis in tumour associated stroma. These studies will lead to the development of novel breast cancer therapies.
Identification Of Target Genes At Breast Cancer-risk Loci With Potential For Drug Repositioning
Funder
National Health and Medical Research Council
Funding Amount
$757,478.00
Summary
Genome wide association studies have been extremely successful at identifying regions of the genome associated with breast cancer risk. However, to fully translate this information to prevention and treatment of breast cancer, we need to understand the molecular mechanisms responsible for increasing breast cancer susceptibility, and the genes that are involved.
Breast CAncer STratification: Understanding The Determinants Of Risk And Prognosis Of Molecular Subtypes
Funder
National Health and Medical Research Council
Funding Amount
$472,984.00
Summary
Breast cancer is not one disease, but many different types with different causes, treatments and outcomes. The aim of this project is to use genetic, lifestyle/environmental, mammographic breast density, pathologic and clinical data froma very large number of studies from all over the world to develop ways of predicting which women are at risk of particuar types of breast cancer, and if breast cancer develops what the likely outcome will be.