Reducing Perinatal Lung, Heart And Brain Injury In Preterm Infants – From Bench To The Clinic.
Funder
National Health and Medical Research Council
Funding Amount
$463,652.00
Summary
Many infants are exposed to an adverse environment whilst developing in the womb, and are therefore at increased risk of lung, heart and brain injury, with life-long consequences. This research is focused on improving the entry into the world of vulnerable infants, thus reducing the risk and severity of brain injury.
Inflammatory lipids are involved in neurotrauma. They are key players in regulating the brain, spinal cord and immune responses to injury and thus in modulating the outcome of central nervous system (CNS) damage. We will investigate how bioactive inflammatory lipids, released during trauma, modulate neural response to injury and regeneration, by assessing their roles on central nervous system responses to injury.
Neuroimaging After Traumatic Brain Injury: What Best Relates To Outcome?
Funder
National Health and Medical Research Council
Funding Amount
$402,287.00
Summary
Brain injury often results in physical difficulties plus cognitive and behavioural problems. Computerised tomography (CT) is the most used form of scanning used after brain injury but does not reveal as much as Magnetic Resonance Imaging (MRI). Electrovestibulography (EvestG) also offers great potential to reveal brain-related information related to injury and depression. This study aims to assess and compare CT, MRI and EvestG to establish the extent to which each can help in predicting outcome ....Brain injury often results in physical difficulties plus cognitive and behavioural problems. Computerised tomography (CT) is the most used form of scanning used after brain injury but does not reveal as much as Magnetic Resonance Imaging (MRI). Electrovestibulography (EvestG) also offers great potential to reveal brain-related information related to injury and depression. This study aims to assess and compare CT, MRI and EvestG to establish the extent to which each can help in predicting outcome in people who have had a brain injury.Read moreRead less
Structural Connectomes In Traumatic Brain Injury: Can Secondary Disease Progression Be Stopped And Cognitive Deficits Be Reversed?
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Many people with traumatic brain injury (TBI) experience cognitive problems, including poor memory and concentration. TBI is often referred to as a ‘hidden disability’ because the overwhelming majority of patients with TBI show no abnormalities on standard MRI or CT scans. In my project, I will delineate the mechanisms of secondary injury in finer detail through enhanced neuroimaging techniques, resulting in new assessment and treatment modalities for individuals with TBI.
Investigating Treatments And Biomarkers Of Brain Concussion
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
Concussions are a serious and common international health concern, and repeated concussions can have severe long-term consequences on the brain. This project will aim to provide insight into this poorly understood disease projects and ultimately improve the management of concussions in human patients.
Refining Methods For Obtaining, Synthesising And Interpreting Research Evidence In Surgery
Funder
National Health and Medical Research Council
Funding Amount
$314,312.00
Summary
Research evidence plays a crucial role in improving clinical care. However the main forms of evidence and the tools that facilitate evidence use - namely randomised controlled trials (RCT) and structured systematic reviews of existing research - have had limited application in surgery for a variety of reasons. This project aims to promote the use of research evidence in surgical decision making by developing tools tailored to the predominance of non-RCTs in surgery and surgeons' information need ....Research evidence plays a crucial role in improving clinical care. However the main forms of evidence and the tools that facilitate evidence use - namely randomised controlled trials (RCT) and structured systematic reviews of existing research - have had limited application in surgery for a variety of reasons. This project aims to promote the use of research evidence in surgical decision making by developing tools tailored to the predominance of non-RCTs in surgery and surgeons' information needs.Read moreRead less
Long-term Outcomes After Paediatric Traumatic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Traumatic brain injuries during early childhood often result in long-lasting issues including social behaviour problems and post-traumatic epilepsy. Using a unique model of brain injury in young mice, my research aims to identify the biology underlying the changes that cause these issues, and evaluate novel approaches to improve long-term outcomes after brain injury.
Immunological Mechanisms And Management Of Serious Illness And Injury
Funder
National Health and Medical Research Council
Funding Amount
$334,539.00
Summary
This fellowship will improve outcomes for seriously ill and injured people, in particular anaphylaxis (life-threatening severe allergy), sepsis (infection) and severe brain injury. Novel laboratory research will be brought to the emergency bedside and integrated with clinical trials aimed at improving outcomes from these conditions. As well as providing immediate benefits in terms of understanding disease processes, this research will pave the way for new therapeutic approaches in the future.
Fetal And Neonatal Therapy To Improve Perinatal Outcome And Long-term Neurodevelopment
Funder
National Health and Medical Research Council
Funding Amount
$214,032.00
Summary
I am a consultant neonatologist with a half-time research appointment. Preventing perinatal morbidity and mortality is one of the greatest challenges in medicine today. My vision is to lead research into new fetal and neonatal therapies, foster collaborations with clinicians and scientists, and improve clinical practice. The scope of my research includes “brain-oriented” program of neonatal intensive care, neuroprotective strategies, and devising new fetal together with the obstetricians.