Stress Hyperglycaemia And Mortality In Critical Illness: Defining The Association And Underlying Mechanisms
Funder
National Health and Medical Research Council
Funding Amount
$125,526.00
Summary
The relationship between high blood sugar levels (hyperglycaemia) and mortality in critically ill patients remains an area of controversy with conflicting results between studies. This PhD thesis will attempt to resolve this by firstly evaluating whether relative hyperglycaemia as measured using a novel new measure better predicts mortality outcome in such patients; and secondly, attempt to establish possible mechanisms which contributes to this.
The Role Of The Osteoblast In Mediating Glucocorticoid-Induced Metabolic Dysfunction
Funder
National Health and Medical Research Council
Funding Amount
$825,254.00
Summary
Glucocorticoids (GC) exceed most other drugs in terms of numbers of patients treated and indications. Preventing or attenuating the deleterious effects of GC on fuel metabolism is therefore of great clinical significance. Our studies will create new knowledge regarding the mechanisms of GC-induced diabetes and osteoporosis, and will contribute to the development of new approaches that are essential to tackle the pressing medical problem of GC-induced disease.
FUNCTIONAL ANALYSIS OF IGF-BINDING PROTEIN-2 MOLECULAR INTERACTIONS IN EARLY DEVELOPMENT AND DISEASE
Funder
National Health and Medical Research Council
Funding Amount
$551,328.00
Summary
Early development involves complex regulation of cell and organ growth. Cell migration and invasion are critical components of epithelial-mesenchymal transition (EMT) essential for early developmental, as well as injury repair and cancer. Common to these events is a highly expressed protein, insulin-like growth factor binding protein-2 (IGFBP-2), which appears to play a critical role in regulating the processes of cell migration and invasion. The underlying mechanisms of cellular regulation by I ....Early development involves complex regulation of cell and organ growth. Cell migration and invasion are critical components of epithelial-mesenchymal transition (EMT) essential for early developmental, as well as injury repair and cancer. Common to these events is a highly expressed protein, insulin-like growth factor binding protein-2 (IGFBP-2), which appears to play a critical role in regulating the processes of cell migration and invasion. The underlying mechanisms of cellular regulation by IGFBP-2 are major focus of this proposal, which brings together four major groups focussed on early development, neural injury repair, and cancer biology. We will use a range of in vitro and in vivo approaches to determine the underlying mechanisms of action of this critical protein. This project has the potential to point to novel therapeutic modalities in development, repair and cancer.Read moreRead less