Promoting engagement with life in older adulthood. This project aims to examine engagement in meaningful activities among older adults. Increasing older adults' engagement could promote direct benefits for social integration, well-being and better quality of life. The project is expected to generate new knowledge on programs that effectively promote engagement, as well as evaluating a new tailored approach to promoting engagement that aligns with individuals' unique strengths, capabilities and ....Promoting engagement with life in older adulthood. This project aims to examine engagement in meaningful activities among older adults. Increasing older adults' engagement could promote direct benefits for social integration, well-being and better quality of life. The project is expected to generate new knowledge on programs that effectively promote engagement, as well as evaluating a new tailored approach to promoting engagement that aligns with individuals' unique strengths, capabilities and values. The findings aim to provide benefits for community organisations and aged care service providers adopting innovative approaches to promoting ageing well.
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Understanding Ageism in Australia. Ageism refers to stereotypes, prejudice and discrimination towards people based on their age. This project aims to generate new knowledge in relation to older Australians’ experiences of ageism by conducting a population-based survey of ageism and examining its links with mental health and wellbeing. The project will also use intensive longitudinal methods to study everyday ageism. Expected outcomes include identification of at-risk groups that can be used to i ....Understanding Ageism in Australia. Ageism refers to stereotypes, prejudice and discrimination towards people based on their age. This project aims to generate new knowledge in relation to older Australians’ experiences of ageism by conducting a population-based survey of ageism and examining its links with mental health and wellbeing. The project will also use intensive longitudinal methods to study everyday ageism. Expected outcomes include identification of at-risk groups that can be used to inform government policy responses to tackling ageism and will inform the development of interventions and education programs to reduce ageism in the community. This should provide significant benefits for social inclusion, intergenerational solidarity and economic participation Read moreRead less
Boosting brain plasticity and motor function in older adults. Ageing is associated with a pronounced decline in many motor, cognitive, and other brain functions, but the cause remains elusive. This project will examine the mechanisms that contribute to a decline in brain plasticity and motor function in the elderly. Using novel brain stimulation techniques, the project aims to develop an optimal approach to boost plasticity in the ageing brain and improve motor function. A better understanding o ....Boosting brain plasticity and motor function in older adults. Ageing is associated with a pronounced decline in many motor, cognitive, and other brain functions, but the cause remains elusive. This project will examine the mechanisms that contribute to a decline in brain plasticity and motor function in the elderly. Using novel brain stimulation techniques, the project aims to develop an optimal approach to boost plasticity in the ageing brain and improve motor function. A better understanding of changes in brain function and plasticity with advancing age is expected to help to optimise the design of preventative programs aimed at rejuvenating motor and cognitive function in the elderly.Read moreRead less
How The Lateral Habenula Integrates Behavioral And Autonomic Functions: The VTA Dopamine Connection
Funder
National Health and Medical Research Council
Funding Amount
$819,904.00
Summary
When adverse events occur, the lateral habenula, an old brain nucleus, helps calculate the wisest corrective action by contributing to the “brake” that controls the brain’s dopamine reward system. Our research will show how the lateral habenula links corrective changes in behavior with coordinated changes in temperature. Understanding this link will greatly contribute to understanding the brain mechanisms that regulate our physiology during stressful situations and as part of mental illness.
Preclinical Evaluation Of The Novel Therapeutic Compound APP96-110 In An Ovine Model Of Traumatic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$874,734.00
Summary
Traumatic brain injury (TBI) is a significant cause of death and disability, and yet there are currently no effective treatments to improve outcome following such an insult. Our laboratory has developed a novel therapeutic compound, by identifying an endogenous neuroprotective molecule, in the amyloid precursor protein and then identifying the active site and modifying it to improve its efficacy. We will be testing this compound in our sheep model of TBI.
Resilient ageing and the oldest-old in the Australian longitudinal study of ageing. This project will provide a better understanding of resiliency (positive adaptation) in oldest-old Australians (85 plus). At a time in history when the population is ageing at an unprecedented rate, understanding how the oldest-old respond adaptively to age-related challenges is critically important to informing ageing policies and service provision.
Reconnecting the ageing brain to enhance plasticity and motor learning. The ability to execute and learn skillful actions deteriorates with advancing age, but the cause remains elusive. The main aim of this project is to use new neurophysiological techniques to examine the age-related changes in brain function that contribute to reduced movement control in healthy older adults. The research will use multimodal approaches to reveal the causal role of age-related changes in specific brain networks ....Reconnecting the ageing brain to enhance plasticity and motor learning. The ability to execute and learn skillful actions deteriorates with advancing age, but the cause remains elusive. The main aim of this project is to use new neurophysiological techniques to examine the age-related changes in brain function that contribute to reduced movement control in healthy older adults. The research will use multimodal approaches to reveal the causal role of age-related changes in specific brain networks to motor behaviour and learning. The outcomes will provide significant new knowledge that may help to optimise the design of targeted interventions aimed at rejuvenating brain function and movement quality in the elderly.Read moreRead less
The dynamics of spousal relationships in very late life: transitions, psychological health and longevity. This research will provide a rare insight into the dynamics of very-long term successful marriages. It will also provide an understanding of the dyad in ageing well. In a society where a large percentage of marriages end in divorce, this work has the potential to identify individual differences factors that are conducive to sustaining the marital relationship. In addition, an examination o ....The dynamics of spousal relationships in very late life: transitions, psychological health and longevity. This research will provide a rare insight into the dynamics of very-long term successful marriages. It will also provide an understanding of the dyad in ageing well. In a society where a large percentage of marriages end in divorce, this work has the potential to identify individual differences factors that are conducive to sustaining the marital relationship. In addition, an examination of how couples from different socio-economic backgrounds navigate later life in their own homes or during key late life transitions will also be beneficial for those individuals or policy makers planning for these transitions.Read moreRead less
Social relations and social engagement in older adulthood: implications for health, well being and cognition. This project will examine the nature of changes in peoples' social networks that occur with age, and the effects of these changes on health and well being in later life. The project will use information collected from several ongoing Australian studies of ageing, and will have important implications for social policy in Australia.
Declining mental efficiency, cognitive performance and individual differences in aged function. Ageing men's health is poorer than women's and men show lower uptake of public health messages. The project has potential to extend the productive involvement of older men in the community, thereby reducing dependence and health care expenditure. Future benefits could also include an effective, convenient, preliminary screening procedure for tracking abnormal cognitive ageing from an early stage amo ....Declining mental efficiency, cognitive performance and individual differences in aged function. Ageing men's health is poorer than women's and men show lower uptake of public health messages. The project has potential to extend the productive involvement of older men in the community, thereby reducing dependence and health care expenditure. Future benefits could also include an effective, convenient, preliminary screening procedure for tracking abnormal cognitive ageing from an early stage among elderly people. This could be also used to target and evaluate interventions designed to moderate morbidity in ageing, or enhance functional capacity with aging. The project will enhance cross-disciplinary expertise and provide doctoral and postdoctoral research training.Read moreRead less