This study investigates how much an individual's genes and environment account for the wide variation in brain structure and function. Using brain imaging we examine in what way the connectivity of the brain of identical and non-identical twins is the same or different from that of their co-twin, and carry out analysis of their DNA to identify some of the genes involved. This will provide fundamental information on genetic mechanisms influencing variation in brain structure and function.
A Prospective Study Of Language Impairment And Recovery Following Surgery For Brain Tumours
Funder
National Health and Medical Research Council
Funding Amount
$861,342.00
Summary
This multi-site project will investigate the incidence and nature of post-operative language difficulties (aphasia) in patients following surgery for left hemisphere primary brain tumours. It will provide comprehensive data concerning risk factors for post-surgical aphasia in Australian patients, in addition to important information about the brain lesions responsible for its various clinical presentations. This information will be used to generate recommendations for clinical practice.
Normal And Abnormal Development Of Brain Wiring And Its Impact On Brain Function
Funder
National Health and Medical Research Council
Funding Amount
$763,845.00
Summary
My laboratory is striving to understand how the patterns of neuronal connections form in the developing brain and how these underpin the functions of the brain throughout life. We use high-field magnetic resonance imaging to measure brain wiring and we investigate the genetic and environmental mechanisms causing developmental brain disorders that result in intellectual disability, autism, epilepsy and some mental illnesses.
Uncovering The Neural Mechanisms Of Obsessive-compulsive Disorder Using Brain Modelling
Funder
National Health and Medical Research Council
Funding Amount
$581,628.00
Summary
Obsessive-compulsive disorder (OCD) is an incurable mental illness and current therapies only mitigate its symptoms for a portion of individuals. Thus, there is a need to identify the neural causes of OCD to develop personalised therapies. We will combine mathematical modelling, computer simulations, and clinical and neuroimaging data to develop the first model of OCD. Outcomes from this study will enable targeted OCD research and the discovery of brain mechanisms supporting treatment response.
Dopamine Neuron Ontogeny: Convergent Neurobiological Pathway For Risk Factors Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$337,214.00
Summary
Schizophrenia is associated with changes in dopamine (a signalling molecule in the brain). These changes are present prior to psychosis, suggesting they begin early in development. Our aims are to manipulate key factors in the development of brain dopamine systems to clarify their role in psychosis and schizophrenia. This work has the potential to identify early brain changes that lead to schizophrenia, which in turn may generate better diagnoses and outcomes for people with this disorder.
Centre For Research Excellence In Speech And Language Neurobiology (CRE-SLANG)
Funder
National Health and Medical Research Council
Funding Amount
$2,491,340.00
Summary
Half a million Australian children have a speech/language disorder, tripling their changes of poor academic outcomes, limited employment options and social isolation. Current speech therapy is limited, focusing on symptoms and ignoring evidence on underlying aetiologies. By identifying and translating findings on new genes and brain pathways leading to speech and language disorders, we will transform detection, diagnosis, prognosis and genetic counselling of affected children and their families.
Discovery Early Career Researcher Award - Grant ID: DE150101180
Funder
Australian Research Council
Funding Amount
$362,000.00
Summary
The neuroethics of cognitive ageing. As the workforce ages, Australian and international governments are prioritising brain health, seeking to increase economic productivity and reduce the costs of age-related cognitive decline. In addition to healthy lifestyle habits, certain neurotechnologies are being promoted as the means to protect cognitive performance. This project aims to explore the ethical issues and social pressures that ageing individuals experience as a result of cognitive ageing. U ....The neuroethics of cognitive ageing. As the workforce ages, Australian and international governments are prioritising brain health, seeking to increase economic productivity and reduce the costs of age-related cognitive decline. In addition to healthy lifestyle habits, certain neurotechnologies are being promoted as the means to protect cognitive performance. This project aims to explore the ethical issues and social pressures that ageing individuals experience as a result of cognitive ageing. Understanding later life from the perspective of ageing individuals may enable society to meet the ethical and policy challenges raised by emphasising cognitive wellbeing above other aspects in the ageing process.Read moreRead less
Remembering to remember: Prospective memory function in everyday life. Prospective memory is a core cognitive skill that refers to memory for future intentions. The goal of this project is to establish when, why and how real-life prospective memory function breaks down at different stages of the adult lifespan and in different everyday contexts - and what strategies most effectively prevent this from occurring. In doing so, this project expects to deliver knowledge that is theoretically transfor ....Remembering to remember: Prospective memory function in everyday life. Prospective memory is a core cognitive skill that refers to memory for future intentions. The goal of this project is to establish when, why and how real-life prospective memory function breaks down at different stages of the adult lifespan and in different everyday contexts - and what strategies most effectively prevent this from occurring. In doing so, this project expects to deliver knowledge that is theoretically transformative, and that delivers the practical understanding of what can be done to reduce real-life vulnerability to prospective memory failures. Given that lapses of prospective memory account for more than half of all daily cognitive errors, this should provide important social and economic benefits for all Australians.
Read moreRead less
Episodic foresight and ageing. Episodic foresight refers to the capacity to imagine future events, and consequently often involves the prediction of future needs based on hypothesised possible outcomes. It is therefore unsurprising that episodic foresight has been consistently linked to independent living and many functional behaviours. The aim of the project is to test the hypothesis that psychological changes brought about by ageing decrease the likelihood of acting prudently with the future i ....Episodic foresight and ageing. Episodic foresight refers to the capacity to imagine future events, and consequently often involves the prediction of future needs based on hypothesised possible outcomes. It is therefore unsurprising that episodic foresight has been consistently linked to independent living and many functional behaviours. The aim of the project is to test the hypothesis that psychological changes brought about by ageing decrease the likelihood of acting prudently with the future in mind. By advancing conceptual understanding of how, and under what circumstances, episodic foresight is affected in late adulthood, the proposed research has important implications for finding ways to help older adults maintain a productive and independent life. Read moreRead less