Understanding And Preventing Inflammatory Pathology Of The Gut
Funder
National Health and Medical Research Council
Funding Amount
$727,758.00
Summary
My research focuses on how inflammation caused by bacteria or organ malfunction can lead to severe disease like cancer in the gastrointestinal tract. Our aim is to better understand diseases like gastric cancer and inflammatory bowel disease, and to develop new ways to detect them and prevent them progressing.
Changing Therapeutic Paradigms For Intestinal Health: Diet As A Therapeutic Strategy In Gastroenterology.
Funder
National Health and Medical Research Council
Funding Amount
$640,210.00
Summary
Irritable bowel syndrome (IBS) affects 1 in 7 adults in Australia. IBS symptoms include abdominal pain, bloating and wind. My team has shown that fermentable short chain carbohydrates (FODMAPs) present in many foods are responsible for triggering these symptoms. The Low FODMAP diet is now being adopted worldwide as first-line management therapy for IBS. The delivery of this research worldwide has been possible through the use of a smartphone app: The Monash Uni Low FODMAP diet.
Translating Gene Discovery For Key Diseases Into Clinical Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$772,490.00
Summary
The goal of the fellowship is capitalize on successful gene mapping studies for endometriosis, inflammatory bowel disease (IBD), melanoma and other complex diseases and conduct functional studies, cross-disease analyses, and genetic studies of response to treatment. These studies will identify specific genes responsible for increased disease risk to understand the biology of these diseases, their relationship with other diseases, and help improve disease management and clinical outcomes.
Helminth Secretomes: From Vaccines To Novel Anti-inflammatory Biologics
Funder
National Health and Medical Research Council
Funding Amount
$938,910.00
Summary
Billions of people in developing countries are infected with parasitic worms, but they have been eradicated from industrialised nations. Humans co-evolved with worms, so their recent removal has deprived us of signals required to keep inflammation in check. My research focuses on worm molecules that can be used to (1) develop vaccines to combat these parasitic infections in developing countries, and (2) as a novel platform of anti-inflammatory therapeutics for use in industrialised nations.
Prof McGuckin is studying common chronic diseases (gut and respiratory inflammatory diseases, arthritis, and obesity and diabetes) that are major contributors to poor health in the Australian community and are major contributors to healthcare expenditure. His research includes basic studies elucidating the biological basis of these diseases and then uses this new knowledge to develop new therapeutic approaches to treatment. The new therapeutic approaches will be tested in model systems as a prel ....Prof McGuckin is studying common chronic diseases (gut and respiratory inflammatory diseases, arthritis, and obesity and diabetes) that are major contributors to poor health in the Australian community and are major contributors to healthcare expenditure. His research includes basic studies elucidating the biological basis of these diseases and then uses this new knowledge to develop new therapeutic approaches to treatment. The new therapeutic approaches will be tested in model systems as a prelude to clinical trials.Read moreRead less