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Role Of IGF Binding Protein-3 (IGFBP-3) And IGFBP-5 As Modulators Of Nuclear Hormone Signalling
Funder
National Health and Medical Research Council
Funding Amount
$465,750.00
Summary
The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain ....The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain cells perform specialised functions. In test-tube experiments, IGFBP-3 and IGFBP-5 interact directly with the receptors that regulate the effects of these hormones. If the same thing happens inside the cell, IGFBP-3 and IGFBP-5 could change the way these receptors respond to signals from outside the cell. We will investigate what effect these IGFBPs have in living cells and in whole animals and how this may relate to human disease. If we are able to understand how IGFBP-3 and IGFBP-5 affect the way cells respond to vitamin A and D, then we may be able to develop new ways to treat certain human diseases.Read moreRead less
Whole Body Vibration For Osteoporosis: Shaking Up Our Treatment Options
Funder
National Health and Medical Research Council
Funding Amount
$961,017.00
Summary
Our aim is to examine the ability of vibration alone and in combination with osteoporosis drugs to reduce hip fracture in postmenopausal women. In Australia, 1 in 2 women >60yrs, will sustain an osteoporotic fracture. Only drugs notably decrease fracture; however none are entirely effective and some patients don’t respond. Whole body vibration has emerged as a potentially effective therapy. A combination of vibration and drugs may enhance the effects of both and revolutionise treatment.
Enabling three dimensional stochastic geological modelling. This project aims to develop technologies to mitigate three dimensional (3D) geological risk in resources management. This project expects to create new knowledge and methods in the field of 3D geological modelling through the innovative application of mathematical methods, structural geology concepts and probabilistic programming. The expected outcomes are an enhanced capability to model the subsurface, characterise model uncertainty a ....Enabling three dimensional stochastic geological modelling. This project aims to develop technologies to mitigate three dimensional (3D) geological risk in resources management. This project expects to create new knowledge and methods in the field of 3D geological modelling through the innovative application of mathematical methods, structural geology concepts and probabilistic programming. The expected outcomes are an enhanced capability to model the subsurface, characterise model uncertainty and test multiple geological scenarios. This enhanced capability is important for the future of Australia's subsurface management, including urban geology and our continuously growing sustainable resources industry.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH130200031
Funder
Australian Research Council
Funding Amount
$3,273,780.00
Summary
ARC Research Hub for Advanced Technologies for Australian Iron Ore. ARC Research Hub for Advanced Technologies for Australian Iron Ore. This Research Hub aims to bring together three world-class groups covering fine particle beneficiation, raw materials handling, and iron ore characterisation to address the complex issues that arise from the different ore types that have emerged in recent years. This Research Hub will focus on the development and adoption of advanced beneficiation and handling t ....ARC Research Hub for Advanced Technologies for Australian Iron Ore. ARC Research Hub for Advanced Technologies for Australian Iron Ore. This Research Hub aims to bring together three world-class groups covering fine particle beneficiation, raw materials handling, and iron ore characterisation to address the complex issues that arise from the different ore types that have emerged in recent years. This Research Hub will focus on the development and adoption of advanced beneficiation and handling technologies into iron ore mining operations, and new knowledge for informing producers and end-users, while providing the training for a new generation of research leaders.Read moreRead less
Three-dimensional Bayesian Modelling of Geological and Geophysical data. The project aims to develop technologies enabling rapid informed decision-making related to the management of natural resources, including critical metals, copper and water. This new technology will support a greener future, securing our energy future, our access to clean water and reduce the mining footprint. Expected outcomes include an enhanced capability in interoperable, integrated three-dimensional geological and geop ....Three-dimensional Bayesian Modelling of Geological and Geophysical data. The project aims to develop technologies enabling rapid informed decision-making related to the management of natural resources, including critical metals, copper and water. This new technology will support a greener future, securing our energy future, our access to clean water and reduce the mining footprint. Expected outcomes include an enhanced capability in interoperable, integrated three-dimensional geological and geophysical modelling in order to predictively characterise sub-surface geology. The outcome will be an open-source forecasting dashboard enabling decision making while considering underlying risk related to resource extractions and management with significant benefits to the Australian society (lower emissions, clean water).Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH130200033
Funder
Australian Research Council
Funding Amount
$2,526,617.00
Summary
ARC Research Hub for Australian Copper-Uranium. ARC Research Hub for Australian Copper-Uranium. This Research Hub aims to develop, test and commercialise new, safe and cost-effective methods to separate radionuclides from copper concentrates derived from copper/uranium ores. The Research Hub will focus on harnessing the expertise and facilities of Australia's key 'resource' companies and universities to enable Australia to position itself as a world leader in copper production and associated tec ....ARC Research Hub for Australian Copper-Uranium. ARC Research Hub for Australian Copper-Uranium. This Research Hub aims to develop, test and commercialise new, safe and cost-effective methods to separate radionuclides from copper concentrates derived from copper/uranium ores. The Research Hub will focus on harnessing the expertise and facilities of Australia's key 'resource' companies and universities to enable Australia to position itself as a world leader in copper production and associated technology.Read moreRead less
Mitigating the negative effects of process water on recovering gold. Low quality water has been used in the minerals industry to save fresh water but shows harmful effects on gold extraction. This project aims to understand the interactions of organic and inorganic components, existing in process water, with gold and determine problematic components that inhibit gold extraction. Expected outcomes will be developed bio-sorbents, based on agriculture waste, that can remove the problematic componen ....Mitigating the negative effects of process water on recovering gold. Low quality water has been used in the minerals industry to save fresh water but shows harmful effects on gold extraction. This project aims to understand the interactions of organic and inorganic components, existing in process water, with gold and determine problematic components that inhibit gold extraction. Expected outcomes will be developed bio-sorbents, based on agriculture waste, that can remove the problematic components in process water efficiently and economically. This will provide major benefits for the minerals industry by providing options to respond and adapt to the impacts of water quality change, leading to increases in yield, revenue and growth of the precious metal sector whilst cutting poisonous chemical consumptions.Read moreRead less
ARC Centre of Excellence for Core to Crust Fluid Systems. Water is essential for human existence, indeed for life's beginning. The circulation of water between the surface and the deep interior lubricates the internal dynamics that keep Earth geologically alive; it is crucial to most Earth systems, including the evolution of the hydrospher/atmosphere/biosphere, and the development of giant ore deposits. However, the origin, abundance, speciation and movements of fluids inside Earth are largely u ....ARC Centre of Excellence for Core to Crust Fluid Systems. Water is essential for human existence, indeed for life's beginning. The circulation of water between the surface and the deep interior lubricates the internal dynamics that keep Earth geologically alive; it is crucial to most Earth systems, including the evolution of the hydrospher/atmosphere/biosphere, and the development of giant ore deposits. However, the origin, abundance, speciation and movements of fluids inside Earth are largely unknown, and represent key issues in modern geoscience. This CoE will integrate previously disparate fields - geology, tectonics, geochemistry, petrophysics, geophysics and dynamic modelling - to understand the workings of Earth's deep plumbing system.Read moreRead less
Depressing pyrite in selective flotation of complex polymetallic ores . This project aims to understand the reactions taking place on the major gangue (waste) mineral during the recovery of base-metal and precious minerals. The mining industry is processing low grade complex ores and experiencing difficulties in rejecting gangue minerals in mineral separation and metal extraction plants. The project will develop new technologies that manipulate these reactions to achieve mineral separation and ....Depressing pyrite in selective flotation of complex polymetallic ores . This project aims to understand the reactions taking place on the major gangue (waste) mineral during the recovery of base-metal and precious minerals. The mining industry is processing low grade complex ores and experiencing difficulties in rejecting gangue minerals in mineral separation and metal extraction plants. The project will develop new technologies that manipulate these reactions to achieve mineral separation and metal extraction efficiently and economically. These technologies may provide value in processing low quality complex polymetallic resources using low quality water, whilst halving the operating costs of mineral concentrators and providing corresponding reductions in harmful emissions.Read moreRead less