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Overcoming Immunosenescence For Effective Stem Cell Therapies
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
An established treatment for blood cancers involves a stem cell transplant to replace the blood stem cells that are damaged by radiation and chemotherapy. However, treatment success is limited with advancing age due to multiple defects in the immune system. We will use new technologies to investigate how the ageing immune system copes with stem cell transplantation and explore new methods for improving recovery and immunity after HSCT.
Bridging The Fields Of Cartilage, Bone Marrow And Cancer Research
Funder
National Health and Medical Research Council
Funding Amount
$470,144.00
Summary
This Fellowship will bring together technologies and expertise in cartilage tissue engineering, in vitro haematopoietic stem cell (HSC) self-renewal, HSC transplantation, and in platform development for the study of prostate cancer bone metastasis. By exploiting the intersection of multiple diseases and tissue platforms, we hope to be able to contribute significantly to improved cartilage repair, bone marrow/cord blood stem cell transplants, and the treatment of metastatic prostate cancer.
Acute Lymphoblastic Leukemia And The Bone Marrow Microenvironment
Funder
National Health and Medical Research Council
Funding Amount
$420,872.00
Summary
This research aims to identify new drugs for the treatment of childhood and adult acute lymphoblastic leukemia (ALL). We have identified drugs that interfere with interactions between the bone marrow and leukemic cells and hypothesise that these will increase the potency of currently used chemotherapy. We will test these agents in animal models of human leukemia. By analysing the effects of these new drugs we will also understand how we can further improve treatments.
Manipulation Of Haematopoietic Stem Cell Niches To Improve Therapeutic Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$451,716.00
Summary
My aim is to understand how stem cells are naturally regulated by the body. My central hypothesis is that local environment (niche) factors largely govern stem cell behaviour. Identification and manipulation of these factors will offer a novel therapeutic opportunity to improve the clinical use of normal haematopoietic stem cells to improve transplantation success, as well as sensitise leukaemia cells to chemotherapy.
Dendritic Cells In Innate Immunity And Their Potential Clinical Manipulation
Funder
National Health and Medical Research Council
Funding Amount
$443,946.00
Summary
Dendritic cells (DC) are rare cells that are crucial in response to infection and surveillance of damaged tissues. We aim to understand the tools that are expressed by DC that allow them to sense pathogens and the functions of different DC types once a pathogen has been detected. The ultimate aim is to be able to understand and harness the functions of different DC so that we may directly target them upon demand to aid in the course of infection or potentially as tumour therapy.
Interactions Between Haematopoietic, Bone, Vascular And Endocrine Systems Control Stem Cell Fate And Mobilization
Funder
National Health and Medical Research Council
Funding Amount
$380,558.00
Summary
Haemopoietic stem cells (HSC) normally reside in the bone marrow (BM) where they make blood and immune cells. We can force HSC to move from the BM into the blood, a process called mobilisation, used to collect large numbers of HSC for transplantation into cancer patients. My research involves identifying factors that control HSC fate within the BM (that is survival, growth, differentiation) and what happens during mobilisation to force them to leave with the aim of improving transplant success.
Osteal Macrophages: Novel Regulators Of Osteoblast Function And The Endosteal Stem Cell Niche
Funder
National Health and Medical Research Council
Funding Amount
$406,125.00
Summary
Bone diseases are a major health problem and current treatments are inadequate. We are investigating a novel role for macrophages (cells important in tissue maintenance and immune responses) in bone growth, repair and disease. Greater understanding of this will provide new ways to treat bone disease. We will also determine if these macrophages help support stem cells that reside near bone surfaces, which may provide new treatment strategies to improve bone marrow transplantation in cancer.