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Environmental Influences In The Establishment Of The Epigenetic Landscape In Children
Funder
National Health and Medical Research Council
Funding Amount
$695,097.00
Summary
The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells ....The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells use epigenetic changes to help control how they grow and develop. Evidence suggests a direct link between diet and environmental influences on our epigenetic profile. Recent research has traced the origins of many of the health problems of adult life back to the earliest periods of development _ to the time spent in the womb and the first few years of life. If we are born with a low birth weight, we are more likely to get sick later in life. Overwhelming evidence exists that the environment in the womb is critical for a healthy birth weight (and health in later life) and it is thought that epigenetics may be the missing link between this environment, low birth weight, and therefore health in later life. In addition, mounting evidence supports a general link between epigenetic de-regulation and predisposition to disease. However, the timing and the overall contribution of environmental- genetic influences to the establishment of faulty epigenetic markings remain largely unknown. Twins are the best model to study this link as they share similar (but not identical environments) and some share identical genetic makeup. Using twins, Dr Jeffrey Craig and his team will investigate the factors in the prenatal environment that modify specific cells, leading to low birth weight and increase disease risk later in life. They predict that this occurs via specific changes in gene activity caused by epigenetic disruption.Read moreRead less
Sustaining India's economic transformation: challenges, prospects and implications for Australia and the Pacific region. India's emergence from economic stagnation is beginning to have a profound impact on the world economy, including Australia. This project aims to investigate the sources of India's growth and the reforms needed to ensure that growth generates reductions in poverty and ensures equity and political stability.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100121
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Three-dimensional super-resolution nanophotonic fabrication facility. This stimulated emission depletion microscopy nanophotonic fabrication facility will be the first nanophotonic fabrication facility that is able to achieve optical resolution far beyond the diffraction limit, which will facilitate breakthroughs in cutting-edge nanotechnology research areas.
Policy Modelling for Ageing in Emerging Economies: The Case of Indonesia. This project, in collaboration with the World Bank and the Indonesian Planning Authority, will support major social and economic policy development in a rapidly ageing region. It will break new ground by developing a cutting-edge economic policy model reflecting salient features of ageing in emerging economies, taking into account the wider implications for education, employment, formalisation, growth, and retirement. It w ....Policy Modelling for Ageing in Emerging Economies: The Case of Indonesia. This project, in collaboration with the World Bank and the Indonesian Planning Authority, will support major social and economic policy development in a rapidly ageing region. It will break new ground by developing a cutting-edge economic policy model reflecting salient features of ageing in emerging economies, taking into account the wider implications for education, employment, formalisation, growth, and retirement. It will bring the armoury of policy analysis instruments available to these countries up to the standard now enjoyed by the developed world. Indonesia, on the brink of major pension reform, will be used as a test bed. Data sets will be developed to allow the model structure to be applied to other emerging economies in Asia. Read moreRead less
Defining Genetic And Epigenetic Variation During Early Development
Funder
National Health and Medical Research Council
Funding Amount
$996,075.00
Summary
We all began life with a set of genes inherited from our parents. However, it's now known that from the time we were in the womb onwards that genes can be turned off and on by the environment or even completely lost or gained. Even what your mother ate or how she behaved while she was pregnant could have influenced your future health. Because people are so different, we are studying the subtle differences between twins to tease out the factors that may influence our genes and our health.
Economic growth and globalisation: identifying costs and benefits. Globalisation provides opportunities to stimulate economic development and growth, but it may also impose costs on national economies. This project will utilise economic theory and econometric analysis to identify the principal sources and the magnitude of such benefits and costs. It will focus on three areas: trade in consumer goods; trade in capital goods; and the importation of knowledge and technology. The results will in ....Economic growth and globalisation: identifying costs and benefits. Globalisation provides opportunities to stimulate economic development and growth, but it may also impose costs on national economies. This project will utilise economic theory and econometric analysis to identify the principal sources and the magnitude of such benefits and costs. It will focus on three areas: trade in consumer goods; trade in capital goods; and the importation of knowledge and technology. The results will inform national policy-making in the areas of trade policy, industry policy, education and R&D.Read moreRead less
Regulation Of Ribosomal RNA Gene Chromatin During Malignant Transformation.
Funder
National Health and Medical Research Council
Funding Amount
$882,486.00
Summary
The overarching goal of this proposal is to determine the molecular basis for tumour cell dependence on activated ribosomal RNA gene repeats (rDNA). Our working model posits that rDNA repeats become activated through changes in rDNA chromatin structure that include increased binding of the RNA Polymerase I transcription factor UBF.
Height, Body Mass Index and Demographic Changes in the Asian Giants. This project aims to examine and explain trends in height and body mass index of the populations of the three Asian Giants, China, India and Indonesia, and to explore the links with two key demographic developments: fertility decline and urbanisation. The three parts of the project are: using anthropometric survey data on adults, to compare, contrast and analyse trends at the national and regional levels; to examine the relatio ....Height, Body Mass Index and Demographic Changes in the Asian Giants. This project aims to examine and explain trends in height and body mass index of the populations of the three Asian Giants, China, India and Indonesia, and to explore the links with two key demographic developments: fertility decline and urbanisation. The three parts of the project are: using anthropometric survey data on adults, to compare, contrast and analyse trends at the national and regional levels; to examine the relationship between adult height and childhood family size using econometric methods that account for possible endogeneity; and, to examine the link between individual BMI and rural or urban residence paying special attention to rural-urban migrants. Read moreRead less
Economic Growth and Real Exchange Rates. Exchange rate movements are important elements of Australia's economic environment. Protectionist interests in the US and Europe, constrained by WTO trade rules, accuse East Asian economies of deliberate undervaluation. While exchange rate movements are not readily predictable in the short run, long run changes in underlying real exchange rates are amenable to economic analysis using structural models. The clearer understanding of these forces, toward ....Economic Growth and Real Exchange Rates. Exchange rate movements are important elements of Australia's economic environment. Protectionist interests in the US and Europe, constrained by WTO trade rules, accuse East Asian economies of deliberate undervaluation. While exchange rate movements are not readily predictable in the short run, long run changes in underlying real exchange rates are amenable to economic analysis using structural models. The clearer understanding of these forces, toward which this project is directed, will better guide investment in the region, including in Australia, and more importantly, it will better inform future policy debates surrounding currency movements.Read moreRead less
Innovation in Australia: Measurement, performance, systems, dynamics and change. This project will produce a comprehensive, integrated analysis of Australia's national innovation system. Through a combination of recent theoretical and conceptual insights and robust empirical analysis the partners will address one of the most pressing issues confronting Australian industrial and research policy. The project will analyze the changes occurring in Australia's innovation system and the drivers beh ....Innovation in Australia: Measurement, performance, systems, dynamics and change. This project will produce a comprehensive, integrated analysis of Australia's national innovation system. Through a combination of recent theoretical and conceptual insights and robust empirical analysis the partners will address one of the most pressing issues confronting Australian industrial and research policy. The project will analyze the changes occurring in Australia's innovation system and the drivers behind them. It will examine the inter-relationships in the development of the innovation system and particular important industrial clusters within it. It will study the impact of globalization, and will compare Australia's innovation system and performance with that of Finland and Canada.Read moreRead less