Role Of IGF Binding Protein-3 (IGFBP-3) And IGFBP-5 As Modulators Of Nuclear Hormone Signalling
Funder
National Health and Medical Research Council
Funding Amount
$465,750.00
Summary
The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain ....The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain cells perform specialised functions. In test-tube experiments, IGFBP-3 and IGFBP-5 interact directly with the receptors that regulate the effects of these hormones. If the same thing happens inside the cell, IGFBP-3 and IGFBP-5 could change the way these receptors respond to signals from outside the cell. We will investigate what effect these IGFBPs have in living cells and in whole animals and how this may relate to human disease. If we are able to understand how IGFBP-3 and IGFBP-5 affect the way cells respond to vitamin A and D, then we may be able to develop new ways to treat certain human diseases.Read moreRead less
Whole Body Vibration For Osteoporosis: Shaking Up Our Treatment Options
Funder
National Health and Medical Research Council
Funding Amount
$961,017.00
Summary
Our aim is to examine the ability of vibration alone and in combination with osteoporosis drugs to reduce hip fracture in postmenopausal women. In Australia, 1 in 2 women >60yrs, will sustain an osteoporotic fracture. Only drugs notably decrease fracture; however none are entirely effective and some patients don’t respond. Whole body vibration has emerged as a potentially effective therapy. A combination of vibration and drugs may enhance the effects of both and revolutionise treatment.
Regulation Of Ribosomal RNA Gene Chromatin During Malignant Transformation.
Funder
National Health and Medical Research Council
Funding Amount
$882,486.00
Summary
The overarching goal of this proposal is to determine the molecular basis for tumour cell dependence on activated ribosomal RNA gene repeats (rDNA). Our working model posits that rDNA repeats become activated through changes in rDNA chromatin structure that include increased binding of the RNA Polymerase I transcription factor UBF.
Targeting Bone Marrow Mediated Angiogenesis And Metastasis In Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$463,006.00
Summary
Despite advances in treatment and diagnostics breast cancer (BC) remains one of the leading causes of death in women. Metastases and tumour blood vessel recruitment are linked. Work by Dr Mellick and others has shown that host bone marrow contributes endothelial progenitor cells (EPCs) to tumour vasculature. The chemokines and their receptors, which differentiate EPCs from tumour vessels, will be knocked down in the tumour cells and EPC progenitors with the aim of preventing tumour spread.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100121
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Three-dimensional super-resolution nanophotonic fabrication facility. This stimulated emission depletion microscopy nanophotonic fabrication facility will be the first nanophotonic fabrication facility that is able to achieve optical resolution far beyond the diffraction limit, which will facilitate breakthroughs in cutting-edge nanotechnology research areas.
Policy Modelling for Ageing in Emerging Economies: The Case of Indonesia. This project, in collaboration with the World Bank and the Indonesian Planning Authority, will support major social and economic policy development in a rapidly ageing region. It will break new ground by developing a cutting-edge economic policy model reflecting salient features of ageing in emerging economies, taking into account the wider implications for education, employment, formalisation, growth, and retirement. It w ....Policy Modelling for Ageing in Emerging Economies: The Case of Indonesia. This project, in collaboration with the World Bank and the Indonesian Planning Authority, will support major social and economic policy development in a rapidly ageing region. It will break new ground by developing a cutting-edge economic policy model reflecting salient features of ageing in emerging economies, taking into account the wider implications for education, employment, formalisation, growth, and retirement. It will bring the armoury of policy analysis instruments available to these countries up to the standard now enjoyed by the developed world. Indonesia, on the brink of major pension reform, will be used as a test bed. Data sets will be developed to allow the model structure to be applied to other emerging economies in Asia. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100199
Funder
Australian Research Council
Funding Amount
$367,900.00
Summary
Advanced Synthesis System for Two-Dimensional Nanomaterials. Advanced synthesis system for two-dimensional nanomaterials:
This project aims to establish the first synthesis facility in Australia for growing large-area and atomically thin two-dimensional (2-D) nanomaterials including graphene, boron nitride, metal dichalcogenides, metal oxide and nitride nanosheets. Such materials are emerging and innovative materials that possess many properties desirable for energy, electronic, biological, and ....Advanced Synthesis System for Two-Dimensional Nanomaterials. Advanced synthesis system for two-dimensional nanomaterials:
This project aims to establish the first synthesis facility in Australia for growing large-area and atomically thin two-dimensional (2-D) nanomaterials including graphene, boron nitride, metal dichalcogenides, metal oxide and nitride nanosheets. Such materials are emerging and innovative materials that possess many properties desirable for energy, electronic, biological, and environmental related applications. This facility is designed to underpin breakthrough science by providing high-quality large-sized materials to researchers for both fundamental and application research. This new synthesis capability would foster advances in the fundamental understanding of 2-D nanostructures and the development of devices with broad applications in energy conversion and storage, environmental protection, and life sciences.Read moreRead less
ASEAN+3 Free Trade Agreement and Its Impact on Australia-Vietnam Trade. The ASEAN+3 (China, Japan and Korea) free trade agreement endorsed by ASEAN Leaders in 2001 poses a serious trade diversion threat to Australia's goods and services trade to ASEAN and North Asia (reaching $33.9b and $85.0b respectively in 2001, see DFAT 2003). No research on this has been done or reported. The project, with Vietnam Institute for Trade collaboration, uses new analytical and empirical approaches to investigate ....ASEAN+3 Free Trade Agreement and Its Impact on Australia-Vietnam Trade. The ASEAN+3 (China, Japan and Korea) free trade agreement endorsed by ASEAN Leaders in 2001 poses a serious trade diversion threat to Australia's goods and services trade to ASEAN and North Asia (reaching $33.9b and $85.0b respectively in 2001, see DFAT 2003). No research on this has been done or reported. The project, with Vietnam Institute for Trade collaboration, uses new analytical and empirical approaches to investigate this FTA and its implications to Australia's trade to a major ASEAN country, namely Vietnam, where 2002 trade reached $2.8b and Australia's global companies (eg. ANZ, Telstra, RMIT) currently have large operation.Read moreRead less