Gene Mining For Novel Molecular Determinants Of The Skeleton
Funder
National Health and Medical Research Council
Funding Amount
$633,447.00
Summary
Musculoskeletal conditions affect over 6 million Australians and research has shown that genetic background strongly influences development of these disorders. This project will identify genes that have a role in controlling bone and joint architecture. Identification of these genes will assist in the development of treatments targeting bone disorders and allow screening for these genes to provide an opportunity for people to take preventative action to improve bone and joint health.
Functional Effects Of Polymorphic Variation Of The Aromatase (CYP19) Gene On Enzyme Activity:relationship To Disease
Funder
National Health and Medical Research Council
Funding Amount
$237,708.00
Summary
After menopause, oestrogen synthesis changes from an ovarian to an adipose source by concersion of androgens to estrogens, a process catalyzed by aromatase, the product of the CYP19 gene. We will generate mutants of the CYP19 gene that we have previously found in humans by site-directed mutagenesis and observe the effects of these mutants on aromatase function. This research will help with diagnosis and treatment of breast and other cancers and osteoporosis in humans .
Mapping the family tree of carbon nanostructures: investigation of nanoscrolls and herringbones. New avenues of research in carbon science will be explored by defining a family tree of carbon nanostructures showing the relationship between forms. This project will investigate the properties of poorly unexplored relatives of the family; the results have the potential to impact on the choice of a material for a given application.
Exploiting shear to form new structures of carbon. This project aims to create new, technologically-interesting, materials by combining shear (sliding forces) with high pressure. The work will use both modelling and experiments to understand the pathways to form new materials such as a different form of diamond that is predicted to be harder than regular diamond. Such a material could be used in coatings for cutting tools or ultra-low-scratch surfaces. Expected outcomes include both an understan ....Exploiting shear to form new structures of carbon. This project aims to create new, technologically-interesting, materials by combining shear (sliding forces) with high pressure. The work will use both modelling and experiments to understand the pathways to form new materials such as a different form of diamond that is predicted to be harder than regular diamond. Such a material could be used in coatings for cutting tools or ultra-low-scratch surfaces. Expected outcomes include both an understanding of the importance of shear in the study of high-pressure science, and as a tool to manufacture new functional materials.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100151
Funder
Australian Research Council
Funding Amount
$760,000.00
Summary
Probe and engineer interactions in atomic-scale devices with a LT STM. A low-temperature scanning tunnelling microscope: The project aims to establish a facility to exploit the spectroscopic and spatial resolution of an ultra-low temperature scanning tunnelling microscope in conjunction with atomically controlled dopant engineering. In a variety of experiments the research team will explore ultra-scaled transistors, quantum information science devices, and engineered quantum matter. Improving ou ....Probe and engineer interactions in atomic-scale devices with a LT STM. A low-temperature scanning tunnelling microscope: The project aims to establish a facility to exploit the spectroscopic and spatial resolution of an ultra-low temperature scanning tunnelling microscope in conjunction with atomically controlled dopant engineering. In a variety of experiments the research team will explore ultra-scaled transistors, quantum information science devices, and engineered quantum matter. Improving our ability to investigate semiconductor materials at the atomic scale impacts fields ranging from electronics, telecommunication, quantum information to renewable energy research and puts Australia at the forefront of the field of controlled atomic systems in semiconductors.Read moreRead less
ARC Centre of Excellence for Engineered Quantum Systems. The future of technology lies in controlling the quantum world. The ARC Centre of Excellence for Engineered Quantum Systems (EQuS) will deliver the building blocks of future quantum technologies and, critically, ensure Australian primacy in this endeavour. Three strategic research programs will target Quantum Measurement and Control; Synthetic Quantum Systems and Simulation; and Quantum-Enabled Sensors and Metrology. Within these programs, ....ARC Centre of Excellence for Engineered Quantum Systems. The future of technology lies in controlling the quantum world. The ARC Centre of Excellence for Engineered Quantum Systems (EQuS) will deliver the building blocks of future quantum technologies and, critically, ensure Australian primacy in this endeavour. Three strategic research programs will target Quantum Measurement and Control; Synthetic Quantum Systems and Simulation; and Quantum-Enabled Sensors and Metrology. Within these programs, our Centre will exploit the deepest principles and resources of quantum physics to solve specific problems in engineering, chemistry biology and medicine, stimulating the Australian scientific and engineering communities to exploit (and benefit from) transformative quantum devices.Read moreRead less
Transforming carbon onions into nanodiamond: technological and astrophysical implications. This project will develop a novel approach for converting carbon into nanometre-sized diamond. Control of the process will lead to a new technology for making diamond coatings and insight into how nanodiamonds form in space.