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Engineering cyanobacteria for high-value flavours and fragrances production. Engineering the metabolism of cyanobacteria for industrial production of flavours and fragrances has great commercial potential. Cyanobacteria capture more than 25% of the planet’s carbon. Due to their native metabolism and capacity to express complex plant proteins, they represent an attractive Synthetic Biology platform for the biosynthesis of flavours and fragrances. Combining physiological strain characterisation an ....Engineering cyanobacteria for high-value flavours and fragrances production. Engineering the metabolism of cyanobacteria for industrial production of flavours and fragrances has great commercial potential. Cyanobacteria capture more than 25% of the planet’s carbon. Due to their native metabolism and capacity to express complex plant proteins, they represent an attractive Synthetic Biology platform for the biosynthesis of flavours and fragrances. Combining physiological strain characterisation and ‘omics studies, new Synthetic Biology strategies and models will be developed. The project aims at engineering a suite of modified freshwater and marine cyanobacteria for flavours and fragrances biosynthesis. The project aims at enabling solar biomanufacturing to underpin the emergence of an advanced Australian bioeconomy.Read moreRead less
Single molecule spectroscopy-guided design of thermostable industrial enzymes. The production and engineering of proteins are key methodologies in life sciences. The current project aims to develop new approaches to accelerate the production and analysis of proteins and to apply them to discover improved proteins for use as feedstock supplements.
Novel oxygen sensing tools for monitoring the effects of dredging on Australian seagrass communities. Seagrass meadows sustain marine biodiversity and the fishing industries on Australian coasts. Dredging of ports and shipping channels is contributing to their rapid global decline. The project will use state-of-the-art technologies in bio-optics and genomics to create a toolkit for seagrass managers to make informed decisions to safeguard seagrass meadows.
Identification of novel biomarkers in tears for prostate cancer diagnosis and prognosis. The purpose of this study is to identify novel biomarkers in the tears of patients with CaP. The use of the several techniques will increase the chance of success and enable us to find more diagnostic markers. If successful, the identified proteins may be used to diagnose and determine the stage of cancer. This will help guide clinicians in choosing the best treatment methods for an individual patient. The m ....Identification of novel biomarkers in tears for prostate cancer diagnosis and prognosis. The purpose of this study is to identify novel biomarkers in the tears of patients with CaP. The use of the several techniques will increase the chance of success and enable us to find more diagnostic markers. If successful, the identified proteins may be used to diagnose and determine the stage of cancer. This will help guide clinicians in choosing the best treatment methods for an individual patient. The markers may also be used to monitor the disease progress and the effects of treatment. The results from this study may improve the prognosis of CaP patients.Read moreRead less
Translating genomic discoveries into improved commercial outcomes for the South Sea pearl industry. The purpose of this project is to understand the relationship between gene expression and pearl quality. By identifying the relationship between genes and pearls this project will determine the best conditions to grow selected pearl oyster stocks for the Australian South Sea pearl industry.
Saving Nemo: Reducing animal use in toxicity assessments of wastewater. Every day, Australians produce ~5 billion litres of wastewater, which contains a cocktail of chemicals. Industries that discharge wastewater are required to assess chemical risks to the receiving environments by conducting whole animal direct toxicity assessments (DTA), which are expensive and pose an ethical dilemma. Our preliminary research shows that new in vitro bioassays provide an ethical and cost effective alternative ....Saving Nemo: Reducing animal use in toxicity assessments of wastewater. Every day, Australians produce ~5 billion litres of wastewater, which contains a cocktail of chemicals. Industries that discharge wastewater are required to assess chemical risks to the receiving environments by conducting whole animal direct toxicity assessments (DTA), which are expensive and pose an ethical dilemma. Our preliminary research shows that new in vitro bioassays provide an ethical and cost effective alternative that could be incorporated into DTA programs if their ecological relevance can be demonstrated. This project will develop and validate a new and internationally significant suite of in vitro bioassays for incorporation into DTA programs, leading to more ethical, cost effective and improved environmental protection.Read moreRead less
Developing a novel carbon negative fertiliser . Food security is vital to support our growing population. However, our increasing reliance on intensive farming systems necessitates increased fertiliser use, leading to increased water pollution and soil degradation - threatening both the Australian environment and food security. Increasing carbon storage capacity by soil and decreasing fertiliser use are two of the primary pathways for restoring the bio-support capacity of soils and reducing farm ....Developing a novel carbon negative fertiliser . Food security is vital to support our growing population. However, our increasing reliance on intensive farming systems necessitates increased fertiliser use, leading to increased water pollution and soil degradation - threatening both the Australian environment and food security. Increasing carbon storage capacity by soil and decreasing fertiliser use are two of the primary pathways for restoring the bio-support capacity of soils and reducing farming footprints. This innovative and first-of-its-kind project aims to develop a cost-effective, carbon negative fertiliser that reduces fertiliser inputs and increases soil carbon storageRead moreRead less
Understanding the koala microbiome: unlocking the secrets of koala health and dietary specialisation, and successful husbandry and translocation. This project aims to discover how the composition and function of koala gastrointestinal microbial communities differ in space and time in response to the varying nutritional quality and chemical composition of koala diets. Using detailed chemical analysis, cutting edge metagenomic and bioinformatic pipelines and powerful approaches to study enzyme fun ....Understanding the koala microbiome: unlocking the secrets of koala health and dietary specialisation, and successful husbandry and translocation. This project aims to discover how the composition and function of koala gastrointestinal microbial communities differ in space and time in response to the varying nutritional quality and chemical composition of koala diets. Using detailed chemical analysis, cutting edge metagenomic and bioinformatic pipelines and powerful approaches to study enzyme functions in the koala’s gut, the investigators aims to reveal the role of microbes in detoxification of plant toxins and degradation of recalcitrant fibre fractions. The outcomes aim to facilitate the use of faecal transplants to improve digestive function for translocated and rehabilitated koalas, enhancing options for koala management and conservation.Read moreRead less
Seafood safety: high throughput diagnostics for ciguatoxin risk assessment. This project aims to develop a novel, high throughput platform for rapidly assessing ciguatoxins. Species of the marine microalgae Gambierdiscus produce ciguatoxins, which accumulate in fish through marine food chains to cause the often debilitating human illness called ciguatera fish poisoning. Ciiguatera fish poisoning is a growing and substantial risk for the $2.2 billion Australian commercial fishing industry. This s ....Seafood safety: high throughput diagnostics for ciguatoxin risk assessment. This project aims to develop a novel, high throughput platform for rapidly assessing ciguatoxins. Species of the marine microalgae Gambierdiscus produce ciguatoxins, which accumulate in fish through marine food chains to cause the often debilitating human illness called ciguatera fish poisoning. Ciiguatera fish poisoning is a growing and substantial risk for the $2.2 billion Australian commercial fishing industry. This serious illness is increasingly impacting more southerly areas of Australia due to environmental changes. The outcomes of this project include new knowledge of the risk of ciguatoxins at Australian 'hot spot' sites, extensively field tested methods for detecting Gambierdiscus and ciguatoxins in situ and key data to inform policy to safeguard the seafood industry and consumers.
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Using photosynthesis to power fine chemical production. This project aims to develop robust, solar driven, enzyme-based biocatalysts to synthesise complex metabolites and biopharmaceutical molecules in single-cell micro-algae. The significance of this project is that solar energy is used to drive challenging chemical reactions inexpensively via photosynthesis. Expected outcomes include sustainable, solar driven production of high-value molecules that are difficult or impossible to synthesise che ....Using photosynthesis to power fine chemical production. This project aims to develop robust, solar driven, enzyme-based biocatalysts to synthesise complex metabolites and biopharmaceutical molecules in single-cell micro-algae. The significance of this project is that solar energy is used to drive challenging chemical reactions inexpensively via photosynthesis. Expected outcomes include sustainable, solar driven production of high-value molecules that are difficult or impossible to synthesise chemically. Benefits include proof-of-principle demonstration of new, light-driven green-chemistry processes for the production of biochemicals, biopharmaceuticals, agricultural and industrial chemicals, extending the diversity of molecules we can make while reducing cost and environmental impact of their production.Read moreRead less