Does Early Overnutrition Differentially Alter Hypothalamic Neuropeptides That Regulate Food Intake In The Rat
Funder
National Health and Medical Research Council
Funding Amount
$346,250.00
Summary
In Australia the incidence of obesity, in particular childhood obesity, is increasing dramatically, and the possible long term consequences of this are of great concern. The brain regulates appetite through a number of chemical transmitters such as neuropeptide Y (NPY) which is present in the brains of mammals and causes increased food intake. The effects of overeating from a young age on these brain transmitters has been largely ignored although this may impact on subsequent eating behaviour. I ....In Australia the incidence of obesity, in particular childhood obesity, is increasing dramatically, and the possible long term consequences of this are of great concern. The brain regulates appetite through a number of chemical transmitters such as neuropeptide Y (NPY) which is present in the brains of mammals and causes increased food intake. The effects of overeating from a young age on these brain transmitters has been largely ignored although this may impact on subsequent eating behaviour. In addition to NPY we will study other transmitters in the brain that have profound effects on appetite, some increasing, and others decreasing, food intake. These may form useful therapeutic targets for new drugs for obesity. Key targets we will study include melanocortins, glucagon-like peptide 1, urocortin, melanin concentrating hormone, agouti related peptide, and NPY. We will determine whether overnutrition from birth to weaning leads to changes in these appetite regulating neurotransmitters in the brain, and monitor the hormonal signals that impact on their activity. We will also determine whether early overnutrition exacerbates the subsequent responses to a high fat diet by comparison with rats made obese as adults. We will measure brain concentrations of the neurotransmitters, the amount released from the brain, and determine whether the feeding responses to injections of these agents is altered in obese animals. We have evidence that these transmitters interact in a co-ordinated fashion to affect feeding; this project will examine whether these interactions are maintained in the various types of obesity. Rats are commonly used for this type of study as the processes regulating feeding are very similar to those in humans and these agents cause similar effects in rats and humans. It is hoped that this information will provide new insight into the way brain adapts to overnutrition, and provide potential treatments for obesity and other feeding disorders.Read moreRead less
Whole Body Vibration For Osteoporosis: Shaking Up Our Treatment Options
Funder
National Health and Medical Research Council
Funding Amount
$961,017.00
Summary
Our aim is to examine the ability of vibration alone and in combination with osteoporosis drugs to reduce hip fracture in postmenopausal women. In Australia, 1 in 2 women >60yrs, will sustain an osteoporotic fracture. Only drugs notably decrease fracture; however none are entirely effective and some patients don’t respond. Whole body vibration has emerged as a potentially effective therapy. A combination of vibration and drugs may enhance the effects of both and revolutionise treatment.
Characterization of Fast Propagating Fires in Green Buildings. This project aims to gain a better understanding of the mechanisms of fast-propagating fires and to address the deficiency in current fire models in assessing the fire safety requirement of green buildings. Although there are many compelling advantages associated with green building designs, because they promote better natural ventilation they could pose a significant fire hazard to occupants due to the propensity of rapid fire and s ....Characterization of Fast Propagating Fires in Green Buildings. This project aims to gain a better understanding of the mechanisms of fast-propagating fires and to address the deficiency in current fire models in assessing the fire safety requirement of green buildings. Although there are many compelling advantages associated with green building designs, because they promote better natural ventilation they could pose a significant fire hazard to occupants due to the propensity of rapid fire and smoke spread within the enclosed space. The new predictive fire model in this project is expected to promote a safer and sustainable building environment.Read moreRead less
Enabling low greenhouse gas emissions from road vehicles through the proper use of alternative fuels. A major increase in alternative transport fuel use appears necessary in our response to the challenges of climate change and energy security. This proposal will advance our fundamental understanding of key aspects of the combustion of particular alternative fuels, thus enabling proper engine design and so maximising greenhouse and energy security benefits. Further, the Australian automotive indu ....Enabling low greenhouse gas emissions from road vehicles through the proper use of alternative fuels. A major increase in alternative transport fuel use appears necessary in our response to the challenges of climate change and energy security. This proposal will advance our fundamental understanding of key aspects of the combustion of particular alternative fuels, thus enabling proper engine design and so maximising greenhouse and energy security benefits. Further, the Australian automotive industry is a major employer and exporter, and needs to develop and/or maintain international leadership in low emission technologies to ensure its long term viability. This proposal builds a consortium of local organisations with common interests, thus helping local industry respond to several, significant challenges that they presently face.Read moreRead less
Development and application of a virtue experimental blast furnace. This project aims to develop a virtual experimental blast furnace based on advanced discrete particle simulation technique. It is intended that the model furnace will be used to study the flow and thermochemical behaviour in iron making, quantify the effects of key variables related to raw material and operational conditions, and formulate strategies for optimum process design and control under different conditions. The findings ....Development and application of a virtue experimental blast furnace. This project aims to develop a virtual experimental blast furnace based on advanced discrete particle simulation technique. It is intended that the model furnace will be used to study the flow and thermochemical behaviour in iron making, quantify the effects of key variables related to raw material and operational conditions, and formulate strategies for optimum process design and control under different conditions. The findings aim to be very useful to comprehensively assess the performance of Australian minerals in iron making, improve the energy efficiency and reduce carbon dioxide emission in the steel industry, and enhance the competitiveness of the Australian economy.Read moreRead less
Multiscale modelling of the transport phenomena of liquid iron and slag in ironmaking blast furnace. Blast furnace ironmaking is a key operation in the steel industry which, with an annual turnover around $11 billion, is a significant manufacturing sector in Australia. This project, focused on the behaviour of liquid iron and slag, can generate computer models that can reliably describe the complicated multiphase flow and thermochemical processes in the furnace. The implementation of the resulta ....Multiscale modelling of the transport phenomena of liquid iron and slag in ironmaking blast furnace. Blast furnace ironmaking is a key operation in the steel industry which, with an annual turnover around $11 billion, is a significant manufacturing sector in Australia. This project, focused on the behaviour of liquid iron and slag, can generate computer models that can reliably describe the complicated multiphase flow and thermochemical processes in the furnace. The implementation of the resultant models and the new understanding should lead to long life campaigns, better operational control, decreased fuel consumption, improved productivity and reduced environmental impact. This, together with the proposed research training, is important to the development of Australia's competitive steel industry.Read moreRead less
Model studies of new ironmaking processes. This project aims to study the fundamentals governing the multiphase flow and thermochemical performance in representative new ironmaking processes, and formulate some useful strategies for the design, control and optimisation of next generation of ironmaking technology which is useful to Australia's future mineral and steel industries.
OPTIMISATION OF COMPACT BOILING HEAT EXCHANGERS USING ARTIFICIAL NEURAL NETWORK. Compact heat exchangers are increasingly considered for duties in many industrial applications, involving phase change processes of boiling and condensation. In many cases such applications are completely new and no previous experience or information is available for constructive design of compact heat exchangers. This project aims to develop a commercially-viable design methodology that will be innovative and novel ....OPTIMISATION OF COMPACT BOILING HEAT EXCHANGERS USING ARTIFICIAL NEURAL NETWORK. Compact heat exchangers are increasingly considered for duties in many industrial applications, involving phase change processes of boiling and condensation. In many cases such applications are completely new and no previous experience or information is available for constructive design of compact heat exchangers. This project aims to develop a commercially-viable design methodology that will be innovative and novel with in mind of robust and speedy computations of key design parameters of compact boiling heat exchangers through the artificial neural networks (ANN) model and maintaining the inherent accuracy associated with the solutions of the boiling flow and heat transfer processes from computational fluid dynamics (CFD) and validated using experimental data. It will provide a cutting edge to the Industry Partner to compete successfully on the local and global market fronts in designing and manufacturing compact boiling heat exchangers.Read moreRead less
A Novel Hybrid Chemical Looping Process for Production of Liquid Hydrocarbon Fuels with a Reduced Greenhouse Gas Emissions Profile. This project determines the fundamental science underpinning the operation of a novel hybrid chemical looping carbon reforming (CLCR) process for production of alternative transportation fuels with a reduced greenhouse gas emissions profile. Compare with conventional processes, the CLCR process features a 50 per cent reduction in the energy and carbon dioxide footpr ....A Novel Hybrid Chemical Looping Process for Production of Liquid Hydrocarbon Fuels with a Reduced Greenhouse Gas Emissions Profile. This project determines the fundamental science underpinning the operation of a novel hybrid chemical looping carbon reforming (CLCR) process for production of alternative transportation fuels with a reduced greenhouse gas emissions profile. Compare with conventional processes, the CLCR process features a 50 per cent reduction in the energy and carbon dioxide footprints and represents a large sink for carbon dioxide sequestration if deployed widely. To achieve the broad objectives of the project comprehensive experimental and modelling studies will be carried out at macro, micro and molecular levels. Expected outcomes include fundamental knowledge essential to the development and commercial-scale deployment of the CLCR process.Read moreRead less