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Blood Pressure Lowering In Patients With Chronic Kidney Disease: Evidence From Prospectively Planned Overview Analyses
Funder
National Health and Medical Research Council
Funding Amount
$257,271.00
Summary
This study will provide highly reliable information about the best way of managing blood pressure in people with chronic kidney disease. It will use sophisticated methods to summarize information from 25 large clinical trials and 160,000 participants to determine whether lowering blood pressure reduces the risk of heart disease and further kidney damage.The study will also determine whether currently recommended blood pressure drugs are those which will provide the most benefit.
The Use Of A Multidrug Pill In Reducing Cardiovascular Events (UMPIRE) Trial
Funder
National Health and Medical Research Council
Funding Amount
$314,535.00
Summary
Patients who have cardiovascular disease are at very high risk of experiencing a heart attack or stroke, and current guidelines recommend the long-term use of aspirin, blood pressure lowering drugs and a cholesterol lowering drug in such patients to reduce their risks. The proposed research will investigate whether the availability of a polypill (a single pill containing all these drugs) will help ensure patients are appropriately prescribed these treatments, and keep taking them long-term. Aust ....Patients who have cardiovascular disease are at very high risk of experiencing a heart attack or stroke, and current guidelines recommend the long-term use of aspirin, blood pressure lowering drugs and a cholesterol lowering drug in such patients to reduce their risks. The proposed research will investigate whether the availability of a polypill (a single pill containing all these drugs) will help ensure patients are appropriately prescribed these treatments, and keep taking them long-term. Australian researchers will have a pivotal role in collecting and interpreting the data in this trial. In addition, Australian researchers will combine the findings of this study with results from similar trials being conducted in Australia (1600 patients, including 600 Aboriginal participants) and New Zealand (600 patients, including 600 Maori participants). This overview will provide very accurate information about the usefulness of the polypill, and how it should be used worldwide.Read moreRead less
Retinal Microvascular Signs In Angina And Coronary Artery Disease: The Australian Heart Eye Study (AHES)
Funder
National Health and Medical Research Council
Funding Amount
$631,223.00
Summary
The Australian Heart Eye Study will determine whether vessel signs from the retina at the back of the eye are an independent marker of heart disease as assessed by a coronary angiogram. New imaging techniques permit a rapid assessment of these signs. This project could lead to the development of an innovative, non-invasive test that could be used to screen people for the risk of coronary heart disease, in addition to traditional risk factors like blood pressure, smoking, cholesterol and obesity.
Providing The Evidence To Guide Adult Immunisation Strategies
Funder
National Health and Medical Research Council
Funding Amount
$492,414.00
Summary
Australia's population is ageing and strategies to improve health in older adults are necessary to prevent an increasing burden on our health system. Adult vaccination is a relatively under-researched area with great potential to prevent disease in the population. This project focuses on four common vaccine preventable disease in adults, herpes zoster (shingles), influenza, invasive pneumococcal disease and pertussis. It will identify what their impact is on the health system and what groups of ....Australia's population is ageing and strategies to improve health in older adults are necessary to prevent an increasing burden on our health system. Adult vaccination is a relatively under-researched area with great potential to prevent disease in the population. This project focuses on four common vaccine preventable disease in adults, herpes zoster (shingles), influenza, invasive pneumococcal disease and pertussis. It will identify what their impact is on the health system and what groups of adults would benefit most from vaccination.Read moreRead less
Screening For Colorectal Cancer: Attitudes Affecting Participation And Implementation Of Strategies For Improvement.
Funder
National Health and Medical Research Council
Funding Amount
$468,760.00
Summary
There is good evidence that population screening for bowel cancer (CRC), based on the detection of blood in stools, is effective in reducing deaths from bowel cancer by around 30-40%. Screening depends on the use of a simple test to identify those who most need the complex and costly test which is capable of accurately detecting curable cancers and precancer lesions. This can be achieved with moderate effectiveness using simple tests (FOBTs) which detect microscopic amounts of blood in the faece ....There is good evidence that population screening for bowel cancer (CRC), based on the detection of blood in stools, is effective in reducing deaths from bowel cancer by around 30-40%. Screening depends on the use of a simple test to identify those who most need the complex and costly test which is capable of accurately detecting curable cancers and precancer lesions. This can be achieved with moderate effectiveness using simple tests (FOBTs) which detect microscopic amounts of blood in the faeces. If we are to reduce the rate of death from CRC, we must have an effective way of encouraging people to do these tests. While much has been learnt from experience with screening for breast and cervical cancer, CRC presents a series of quite different issues that have never been comprehensively studied. These are: (1) men and women need to be screened. (2) symptoms due to CRC are more complex , (3) the high-risk settings for CRC are much more complex), (4) the community is not as aware of the benefit of screening, (5) the initial test can be performed at personal convenience in one's home, (6) participants must handle bodily excretions, and (7) inconvenience of attending a central facility is avoided. We will survey participants and non-participants to more accurately identify the barriers to screening, and the proportion who have not participated for informed reasons. To test the real value of attempts to overcome these, we will then offer screening by various approaches designed to overcome these. We are in a unique position to do this as we have well-identified populations who have been offered faecal occult blood test (FOBT)-based screening These studies will assist in the design and implementation of effective screening programs for the early detection of CRC in Australia, which in the long term will significantly reduce deaths from this disease.Read moreRead less
Development Of Contemporary Surveillance And Control Methodologies For Dengue And Other Mosquito-borne Viral Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$512,290.00
Summary
This research proposal will address the need for better surveillance and control methodologies for mosquito-borne viral diseases and their vectors, including dengue and its global mosquito vector, Ae. aegypti, and a range of other important arboviral diseases throughout Australia. Research will focus in three areas: surveillance and control of Ross River and Barmah Forest viruses; development of contemporary risk management frameworks for dengue; and innovative investigations of insect age to pr ....This research proposal will address the need for better surveillance and control methodologies for mosquito-borne viral diseases and their vectors, including dengue and its global mosquito vector, Ae. aegypti, and a range of other important arboviral diseases throughout Australia. Research will focus in three areas: surveillance and control of Ross River and Barmah Forest viruses; development of contemporary risk management frameworks for dengue; and innovative investigations of insect age to provide evidence based monitoring and novel approaches to arbovirus disease prevention.Read moreRead less