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INcidence And Progression Of Retinal Microvascular Signs In An Older Australian Cohort
Funder
National Health and Medical Research Council
Funding Amount
$62,022.00
Summary
This project aims to investigate the evolution of retinal microvascular signs and associated factors in an older, general population. 1. To investigate the 5-year and the 10-year incidence, progression and regression of retinal vascular wall signs in an older Australian population; 2. To relate the incidence, progression and regression of retinal vascular wall signs to cardiovascular risk factors (a: age, blood pressure; b: metabolic factors such as BMI, lipids and glucose levels); 3. To investi ....This project aims to investigate the evolution of retinal microvascular signs and associated factors in an older, general population. 1. To investigate the 5-year and the 10-year incidence, progression and regression of retinal vascular wall signs in an older Australian population; 2. To relate the incidence, progression and regression of retinal vascular wall signs to cardiovascular risk factors (a: age, blood pressure; b: metabolic factors such as BMI, lipids and glucose levels); 3. To investigate the incidence, progression and regression of retinal vascular wall signs in relation to inflammatory markers (white cell count, fibrinogen, hematocrit, platelet count); 4. To investigate the incidence, progression and regression of retinal vascular wall signs in relation to medication use (a: anti-hypertensive medications; b: aspirin and other NSAIDs; c. steroid use); 5. To relate the incidence, progression and regression of retinal vascular wall signs to specific lifestyle behaviours (alcohol consumption, smoking, exercise); 6. To investigate the incidence, progression and regression of retinal vascular wall signs and hormone replacement therapy use in women.Read moreRead less
Time-domain Analysis Of Right Ventricular-pulmonary Arterial Coupling As A Windkessel And Wave System.
Funder
National Health and Medical Research Council
Funding Amount
$64,631.00
Summary
We seek to determine the number of people affected by pulmonary arterial hypertension (high blood pressure in the lungs) in Tasmania by collecting information from echocardiograms (heart ultrasounds). This is important because the incidence and prevalence is unknown but suspected to be unusually high in Tasmania. Also simultaneous pulmonary arterial pressure and velocity waves will be studied in humans to model pulmonary flow in an attempt to recognise pulmonary arterial hypertension earlier.
Investigating The Mechanisms Underpinning The Dynamic Vessel Response In People With Diabetic Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$18,808.00
Summary
Endothelial dysfunction has been well-hypothesised as one of the key players in the pathogenesis of DR. However, there is strong evidence suggesting a neurovascular coupling mechanism in the retinal circulation during flicker. It is therefore unclear whether reduced flicker light induced vasodilation observed in diabetes and DR is associated with endothelial dysfunction, an impairment of neurovascular coupling or both. This project aims to address this important knowledge gap.
Coronary Atherosclerosis And Its Relationship With Platelet Activation
Funder
National Health and Medical Research Council
Funding Amount
$101,039.00
Summary
Blood clots are critical to the development of heart attacks, which kill many thousands of Australians annually. Platelets are cells in the blood that play an essential role in formation of blood clots, and coronary disease is associated with platelet activation. This research study will investigate the nature of platelet activation in the arteries of the human heart, its relationship to activation of inflammatory cells, and to the severity of narrowings in the arteries of the human heart.
Blood And Blood Product Transfusion In Trauma Resuscitation
Funder
National Health and Medical Research Council
Funding Amount
$98,431.00
Summary
Blood is an exceedingly scarce and expensive resource. Massive transfusions place enormous strains on blood banks. There is little consensus and a paucity of evidence on transfusion practice in major trauma. Trauma patients account for a significant proportion of all patients who receive transfusions. This project will assist with the development of more uniform guidelines for transfusion of blood products in major trauma patients based on the best evidence available and current practice.