Production Of Large Scale Erythroid Progenitor Cultures From Human Embryonic Stem Cells
Funder
National Health and Medical Research Council
Funding Amount
$396,718.00
Summary
Transfusion of fresh red blood cell units of the correct blood type into patients can be life saving. However, access to units of the correct blood type is often limited due to limited supply of donor blood and its short shelf life creating the need for a constant donor blood supply. We propose to develop a system that allows us to generate unlimited numbers of human red blood cells in a culture dish which we will derive from differentiating human embryonic stem cell lines.
Blood And Blood Product Transfusion In Trauma Resuscitation
Funder
National Health and Medical Research Council
Funding Amount
$98,431.00
Summary
Blood is an exceedingly scarce and expensive resource. Massive transfusions place enormous strains on blood banks. There is little consensus and a paucity of evidence on transfusion practice in major trauma. Trauma patients account for a significant proportion of all patients who receive transfusions. This project will assist with the development of more uniform guidelines for transfusion of blood products in major trauma patients based on the best evidence available and current practice.
Trial To Evaluate Anti-fibrinolytic Therapy In Thrombocytopenia (TREATT)
Funder
National Health and Medical Research Council
Funding Amount
$1,057,478.00
Summary
Patients with haematologic malignancies often have low platelet counts from their disease or treatment. This can be associated with bleeding, which can sometimes be serious or fatal. Nearly 2/3 of all platelet transfusions in Australia are given in this setting to try to prevent bleeding but many people still experience bleeding. This study asks whether tranexamic acid can safely & effectively reduce bleeding and if it does, does reduced bleeding lead to reduction in platelet transfusions?
Blood transfusion is a vital part of medical practice. Patients expect that this treatment will be given only where it will help them, while the community expects that the money spent on transfusion is being spent wisely. The proposed program of work addresses critical deficits in understanding in transfusion medicine. It will improve the evidence base to inform clinical decision-making, provide strategies which ensure this evidence is translated promptly into clinical practice, and extend this ....Blood transfusion is a vital part of medical practice. Patients expect that this treatment will be given only where it will help them, while the community expects that the money spent on transfusion is being spent wisely. The proposed program of work addresses critical deficits in understanding in transfusion medicine. It will improve the evidence base to inform clinical decision-making, provide strategies which ensure this evidence is translated promptly into clinical practice, and extend this evidence base to inform clinical policy and planning in Australia.Read moreRead less
Improving Outcomes For Patients With Critical Bleeding Requiring Massive Transfusion
Funder
National Health and Medical Research Council
Funding Amount
$877,786.00
Summary
Blood transfusions— the most common procedure in Australian hospitals —are life-saving for people with uncontrolled bleeding. They cost Australia more than $1 billion each year and despite their life-saving potential their risks are concerning. This project, led by ANZ researchers, health professionals, blood service stakeholders and government representatives, will provide new information about how to improve the safety and outcomes of patients receiving blood transfusions in our hospitals.
Improving Patient Outcomes Through Understanding And Changing Transfusion Practice
Funder
National Health and Medical Research Council
Funding Amount
$75,347.00
Summary
Blood transfusion has a central role in many areas of clinical medicine. Despite its widespread use, there are large areas where evidence to inform clinical practice is limited. The aim of this proposed research is to investigate the current use of blood products in clinical medicine. Data on blood transfusion will be linked with existing clinical registries to examine how transfusion practice influences patient outcomes in a range of clinical areas including trauma, surgery and critical care.
Investigation Of Dok2 And Dok1 Adapter Proteins, In The Negative Regulation Of Integrin AIIbb3 Platelet Signalling.
Funder
National Health and Medical Research Council
Funding Amount
$446,831.00
Summary
Blood platelets play a key role in blood clot formation, prevention of bleeding and are the principal elements contributing to thrombosis leading to heart attack and stroke. Numerous studies have defined pathways promoting platelet activity, however less is known about their negative regulation. In this grant we will examine the role for proteins, Dok2 and Dok1, in the negative regulation of platelets, hoping this leads to development of novel therapeutics for prevention of cardiac disease.